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Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Li, Lu; Xu, Weijie; Luo, Yinzhu; Lao, Chunqin; Tong, Xueli; Du, Junxi; Huang, Bihong; Li, Di; Chen, Jingmian; Ye, Huiling; Cong, Feng; Guo, Xiaofeng; Li, Jiejing.
  • Li L; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Xu W; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Luo Y; Guangdong Laboratory Animal Monitoring Institute and Guangdong Key Laboratory of Laboratory Animals, Guangzhou 510633, China.
  • Lao C; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Tong X; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Du J; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Huang B; Guangdong Laboratory Animal Monitoring Institute and Guangdong Key Laboratory of Laboratory Animals, Guangzhou 510633, China.
  • Li D; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Chen J; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Ye H; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China.
  • Cong F; Guangdong Laboratory Animal Monitoring Institute and Guangdong Key Laboratory of Laboratory Animals, Guangzhou 510633, China. Electronic address: congfeng521@126.com.
  • Guo X; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of Gastroenterology, Gua
  • Li J; Guangzhou Oriplamacy Technology Co., Ltd., Guangzhou, Guangdong 510000, China; Department of R&D, Biotech&Science Company of UP, Ltd., Guangzhou, Guangdong 510000, China; Guangzhou Ultimate molecule Technology Co., Ltd., Guangzhou, Guangdong 510000, China. Electronic address: xenjiejingli@gm
Carbohydr Polym ; 297: 120032, 2022 Dec 01.
Статья в английский | MEDLINE | ID: covidwho-2068751
ABSTRACT
The cytokine storm is highly associated with inflammatory-type disease severity and patients' survival. Plant polysaccharides, the main natural phytomedicine source, have a great potential to be an effective drug to treat cytokine storm. Herein we found that a polymeric acemannan (ABPA1) isolated from Aloe Vera Barbadensis extract C (AVBEC) exerted prominent inhibitory effects on inflammation-induced cytokine storm. The results displayed that ABPA1 effectively suppressed LPS-induced proinflammatory cytokines release in vitro. Moreover, ABPA1 treatment alleviated the cytokine storm and tissue damage in LPS- and IAV-induced mouse pneumonia models, and altered the phenotypic balance of macrophages in lung tissues. Functionally, ABPA1 enhanced macrophage M2 polarization and phagocytosis in RAW264.7 cells and inhibited LPS-induced M1 polarization. Mechanistically, ABPA1 enhanced mitochondrial metabolism and OXPHOS through activated PI3K/Akt/GSK-3ß signalling pathway. Overall, our findings suggest that ABPA1 may modulate macrophage activation and mitochondrial metabolism by targeting PI3K/Akt/GSK-3ß signalling pathway, thereby alleviating cytokine storm and inflammation.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Aloe Тип исследования: Прогностическое исследование Пределы темы: Животные Язык: английский Журнал: Carbohydr Polym Год: 2022 Тип: Статья Аффилированная страна: J.carbpol.2022.120032

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Aloe Тип исследования: Прогностическое исследование Пределы темы: Животные Язык: английский Журнал: Carbohydr Polym Год: 2022 Тип: Статья Аффилированная страна: J.carbpol.2022.120032