The health facility as a risk factor for multidrug-resistant gram-negative bacteria in critically ill patients with COVID-19.
Clinics (Sao Paulo)
; 77: 100130, 2022.
Статья
в английский
| MEDLINE | ID: covidwho-2068802
ABSTRACT
BACKGROUND:
The relationship between Multidrug Resistant-Gram Negative Bacteria (MDR-GNB) infection and colonization in critically ill COVID-19 patients has been observed, however, it is still poorly understood. This study evaluated the risk factors for acquiring MDR-GNB in patients with severe COVID-19 in Intensive Care Units (ICU).METHODS:
This is a nested case-control study in a cohort of 400 adult patients (≥ 18 years old) with COVID-19, hospitalized in the ICU of 4 hospitals in the city of Curitiba, Brazil. Cases were critical COVID-19 patients with one or more MDR GNB from any surveillance and/or clinical cultures were taken during their ICU stay. Controls were patients from the same units with negative cultures for MDR-GNB. Bivariate and multivariate analyses were done.RESULTS:
Sixty-seven cases and 143 controls were included. Independent risk factors for MDR bacteria were male gender (OR = 2.6; 95% CI 1.28â5.33; p = 0.008); the hospital of admission (OR = 3.24; 95% CI 1.39â7.57; p = 0.006); mechanical ventilation (OR = 25.7; 95% CI 7.26â91; p < 0.0001); and desaturation on admission (OR = 2.6; 95% CI 1.27â5.74; p = 0.009).CONCLUSIONS:
Male gender, desaturation, mechanical ventilation, and the hospital of admission were the independent factors associated with MDR-GNB in patients in the ICU with COVID-19. The only modifiable factor was the hospital of admission, where a newly opened hospital posed a higher risk. Therefore, coordinated actions toward a better quality of care for critically ill COVID-19 patients are essential.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Cross Infection
/
Gram-Negative Bacterial Infections
/
COVID-19
Тип исследования:
Когортное исследование
/
Экспериментальные исследования
/
Наблюдательное исследование
/
Прогностическое исследование
/
Рандомизированные контролируемые испытания
Пределы темы:
Подростки
/
Взрослые
/
Люди
/
Мужчины
Язык:
английский
Журнал:
Clinics (Sao Paulo)
Тематика журнала:
Медицина
Год:
2022
Тип:
Статья
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