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Predictors of carbapenem-resistant Enterobacteriaceae (CRE) strains in patients with COVID-19 in the ICU ward: a retrospective case-control study.
Vlad, Nicoleta-Dorina; Cernat, Roxana Carmen; Carp, Sorina; Mitan, Romelia; Dumitru, Andrei; Nemet, Codruța; Voidazan, Septimiu; Rugina, Sorin; Dumitru, Irina-Magdalena.
  • Vlad ND; Department of Infectious Diseases, Clinical Infectious Diseases Hospital, Constanța, Romania.
  • Cernat RC; Department of Doctoral School of Medicine, Ovidius University of Constanța, Constanta, Romania.
  • Carp S; Department of Infectious Diseases, Clinical Infectious Diseases Hospital, Constanța, Romania.
  • Mitan R; Department of Infectious Diseases, Faculty of Medicine, Ovidius University of Constanța, Constanța, Romania.
  • Dumitru A; Department of Infectious Diseases, Clinical Infectious Diseases Hospital, Constanța, Romania.
  • Nemet C; Department of Infectious Diseases, Clinical Infectious Diseases Hospital, Constanța, Romania.
  • Voidazan S; Department of Doctoral School of Medicine, Ovidius University of Constanța, Constanta, Romania.
  • Rugina S; Department of Epidemiology, Transilvania University of Brașov, Brașov, Romania.
  • Dumitru IM; Department of Epidemiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, Targu Mures, Romania.
J Int Med Res ; 50(10): 3000605221129154, 2022 Oct.
Статья в английский | MEDLINE | ID: covidwho-2079248
ABSTRACT

OBJECTIVE:

To identify carbapenem-resistant Enterobacteriaceae (CRE) in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) and to determine whether they had different risk factors for the acquisition of CRE than patients without COVID-19.

METHODS:

This retrospective single-centre, case-control study enrolled patients with and without COVID-19. The demographic, clinical, infection, colonization and mortality data were compared between the two groups.

RESULTS:

A total of 38 patients with COVID-19 and 26 patients without COVID-19 were enrolled. The majority of isolates detected in COVID-19 patients were Klebsiella spp. Leukopenia at admission (odds ratio [OR] 4.70; 95% confidence interval [CI] 1.37, 16.10), invasive mechanical ventilation (OR 5.74; 95% CI 1.07, 30.63), carbapenem treatment (OR 5.09; 95% CI 1.21, 21.27) and corticosteroid treatment (OR 7.06; 95% CI 1.53, 32.39) were independent risk factors for CRE acquisition in COVID-19 patients. Intensive care unit (ICU) mortality was significantly higher in COVID-19 patients compared with patients without COVID-19 (OR 20.62; 95% CI 5.50, 77.23). Length of ICU stay increased the risk of death in patients with COVID-19 (subdistribution hazard ratio 3.81; 95% CI 1.33, 10.92).

CONCLUSION:

CRE strains were more common in patients with COVID-19 and they had different risks for CRE compared with patients without COVID-19.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Enterobacteriaceae Infections / Carbapenem-Resistant Enterobacteriaceae / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Люди Язык: английский Журнал: J Int Med Res Год: 2022 Тип: Статья Аффилированная страна: 03000605221129154

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Enterobacteriaceae Infections / Carbapenem-Resistant Enterobacteriaceae / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Люди Язык: английский Журнал: J Int Med Res Год: 2022 Тип: Статья Аффилированная страна: 03000605221129154