In-hospital Mortality Rates in SARS-CoV-2 Patients Treated with Enoxaparin and Heparin.
Clin Appl Thromb Hemost
; 28: 10760296221131802, 2022.
Статья
в английский
| MEDLINE | ID: covidwho-2089101
ABSTRACT
OBJECTIVES:
This study aimed to investigate in-hospital mortality rates in patients with coronavirus disease (COVID-19) according to enoxaparin and heparin use.METHODS:
This retrospective cohort study included 962 patients admitted to two hospitals in Kuwait with a confirmed diagnosis of COVID-19. Cumulative all-cause mortality rate was the primary outcome.RESULTS:
A total of 302 patients (males, 196 [64.9%]; mean age, 57.2 ± 14.6 years; mean body mass index, 29.8 ± 6.5â kg/m2) received anticoagulation therapy. Patients receiving anticoagulation treatment tended to have pneumonia (n = 275 [91.1%]) or acute respiratory distress syndrome (n = 106 [35.1%]), and high D-dimer levels (median [interquartile range] 608 [523;707] ng/mL). The mortality rate in this group was high (n = 63 [20.9%]). Multivariable logistic regression, the Cox proportional hazards, and Kaplan-Meier models revealed that the use of therapeutic anticoagulation agents affected the risk of all-cause cumulative mortality.CONCLUSION:
Age, hypertension, pneumonia, therapeutic anticoagulation, and methylprednisolone use were found to be strong predictors of in-hospital mortality. In elderly hypertensive COVID-19 patients on therapeutic anticoagulation were found to have 2.3 times higher risk of in-hospital mortality. All cause in-hospital mortality rate in the therapeutic anticoagulation group was up to 21%.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
SARS-CoV-2
/
COVID-19 Drug Treatment
Тип исследования:
Когортное исследование
/
Наблюдательное исследование
/
Прогностическое исследование
Пределы темы:
Взрослые
/
Пожилые
/
Люди
/
Мужчины
/
Middle aged
Язык:
английский
Журнал:
Clin Appl Thromb Hemost
Тематика журнала:
Болезни системы кровообращения
Год:
2022
Тип:
Статья
Аффилированная страна:
10760296221131802
Документы, близкие по теме
MEDLINE
...
LILACS
LIS