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Revealing key regulators of neutrophil function during inflammation by re-analysing single-cell RNA-seq.
Ai, Zhichao.
  • Ai Z; China Innovation Center of Roche (CICoR), Roche R&D Center (China) Ltd, Shanghai, China.
PLoS One ; 17(10): e0276460, 2022.
Статья в английский | MEDLINE | ID: covidwho-2089429
ABSTRACT
Excessive neutrophil infiltration and dysfunction contribute to the progression and severity of hyper-inflammatory syndrome, such as in severe COVID19. In the current study, we re-analysed published scRNA-seq datasets of mouse and human neutrophils to classify and compare the transcriptional regulatory networks underlying neutrophil differentiation and inflammatory responses. Distinct sets of TF modules regulate neutrophil maturation, function, and inflammatory responses under the steady state and inflammatory conditions. In COVID19 patients, neutrophil activation was associated with the selective activation of inflammation-specific TF modules. SARS-CoV-2 RNA-positive neutrophils showed a higher expression of type I interferon response TF IRF7. Furthermore, IRF7 expression was abundant in neutrophils from severe patients in progression stage. Neutrophil-mediated inflammatory responses positively correlate with the expressional level of IRF7. Based on these results, we suggest that differential activation of activation-related TFs, such as IRF7 mediate neutrophil inflammatory responses during inflammation.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 / Neutrophils Тип исследования: Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: PLoS One Тематика журнала: Наука / Медицина Год: 2022 Тип: Статья Аффилированная страна: Journal.pone.0276460

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 / Neutrophils Тип исследования: Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: PLoS One Тематика журнала: Наука / Медицина Год: 2022 Тип: Статья Аффилированная страна: Journal.pone.0276460