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Lentinus edodes Polysaccharides Alleviate Acute Lung Injury by Inhibiting Oxidative Stress and Inflammation.
Zhang, Yiwen; Cui, Yanfei; Feng, Yanbo; Jiao, Fengping; Jia, Le.
  • Zhang Y; College of Life Science, Shandong Agricultural University, Taian 271018, China.
  • Cui Y; College of Life Science, Shandong Agricultural University, Taian 271018, China.
  • Feng Y; College of Life Science, Shandong Agricultural University, Taian 271018, China.
  • Jiao F; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
  • Jia L; College of Life Science, Shandong Agricultural University, Taian 271018, China.
Molecules ; 27(21)2022 Oct 28.
Статья в английский | MEDLINE | ID: covidwho-2090286
ABSTRACT
Acute lung injury (ALI) is a kind of lung disease with acute dyspnea, pulmonary inflammation, respiratory distress, and non-cardiogenic pulmonary edema, accompanied by the mid- and end-stage characteristics of COVID-19, clinically. It is imperative to find non-toxic natural substances on preventing ALI and its complications. The animal experiments demonstrated that Lentinus edodes polysaccharides (PLE) had a potential role in alleviating ALI by inhibiting oxidative stress and inflammation, which was manifested by reducing the levels of serum lung injury indicators (C3, hs-CRP, and GGT), reducing the levels of inflammatory factors (TNF-α, IL-1ß, and IL-6), and increasing the activities of antioxidant enzymes (SOD and CAT) in the lung. Furthermore, PLE had the typical characteristics of pyran-type linked by ß-type glycosidic linkages. The conclusions indicated that PLE could be used as functional foods and natural drugs in preventing ALI.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Shiitake Mushrooms / Acute Lung Injury / COVID-19 Тип исследования: Прогностическое исследование Пределы темы: Животные Язык: английский Тематика журнала: Биология Год: 2022 Тип: Статья Аффилированная страна: Molecules27217328

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Shiitake Mushrooms / Acute Lung Injury / COVID-19 Тип исследования: Прогностическое исследование Пределы темы: Животные Язык: английский Тематика журнала: Биология Год: 2022 Тип: Статья Аффилированная страна: Molecules27217328