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Endocarditis-TR: Diagnosis, treatment, and prognosis of the infective endocarditis patients admitting tertiary centres of Turkey.
Çalik, Ali Nazmi; Özlük, Özlem Arican; Karatas, Mehmet Baran; Çanga, Yigit; Eren, Semih; Ayhan, Görkem; Akdeniz, Ayse; Palice, Ali; Candemir, Aytaç; Akyüz, Sükrü; Zoghi, Mehdi; Kozan, Ömer.
  • Çalik AN; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Özlük ÖA; Department of Cardiology, Faculty of Medicine, Bursa Yüksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
  • Karatas MB; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Çanga Y; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Eren S; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Ayhan G; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Akdeniz A; Department of Cardiology, Faculty of Medicine, Bursa Yüksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
  • Palice A; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Candemir A; Department of Cardiology, Faculty of Medicine, Ege University, Izmir, Turkey.
  • Akyüz S; Department of Cardiology, Faculty of Medicine, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Zoghi M; Department of Cardiology, Faculty of Medicine, Ege University, Izmir, Turkey.
  • Kozan Ö; Department of Cardiology, Faculty of Medicine, Baskent University, Istanbul, Turkey.
Turk J Med Sci ; 52(2): 445-455, 2022 Apr.
Статья в английский | MEDLINE | ID: covidwho-2101116
ABSTRACT

BACKGROUND:

Infective endocarditis (IE) is still a significant cause of morbidity and mortality among cardiovascular diseases. ENDOCARDITIS-TR study aims to evaluate the compliance of the diagnostic and therapeutic methods being used in Turkey with current guidelines.

METHODS:

The ENDOCARDITIS-TR trial is a multicentre, prospective, observational study consisting of patients admitted to tertiary centres with a definite diagnose of IE. In addition to the demographic, clinical, microbiological, and echocardiographic findings of the patients, adverse events, indications for surgery, and in-hospital mortality were recorded during a 2-year time interval.

RESULTS:

A total of 208 IE patients from 7 tertiary centres in Turkey were enrolled in the study. The study population included 125 (60.1%) native valve IE (NVE), 65 (31.3%) prosthetic IE (PVIE), and 18 (8.7%) intracardiac device-related IE (CDRIE). One hundred thirty-five patients (64.9%) were culture positive, and the most frequent pathogenic agent was methicillin-susceptible Staphylococcus aureus (MSSA) (18.3%). Among 155 (74.5%) patients with an indication for surgery, only 87 (56.1%) patients underwent surgery. The all-cause mortality rate was 29.3% in-hospital follow-up. Multivariable Cox regression analysis revealed that absence of surgery when indicated (HR 3.29 95% CI 0.93-11.64 p = 0.05), albumin level at admission (HR 0.46 95% CI 0.29-0.73 P < 0.01), abscess formation (HR 2.11 95% CI 1.01-4.38 p = 0.04) and systemic embolism (HR 1.78 95% CI 1.05-3.02 p = 0.03) were ascertained independent predictors of in-hospital all-cause mortality.

DISCUSSION:

The short-term results of the ENDOCARDITIS-TR trial showed the high frequency of staphylococcal IE, relatively high in-hospital mortality rates, shortage of surgical treatment despite guideline-based surgical indications and low usage of novel imaging techniques. The results of this study will provide a better insight to physicians in respect to their adherence to clinical practice guidelines.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Endocarditis / Endocarditis, Bacterial Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Люди Страна как тема: Азия Язык: английский Журнал: Turk J Med Sci Год: 2022 Тип: Статья Аффилированная страна: 1300-0144.5332

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Endocarditis / Endocarditis, Bacterial Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Люди Страна как тема: Азия Язык: английский Журнал: Turk J Med Sci Год: 2022 Тип: Статья Аффилированная страна: 1300-0144.5332