Your browser doesn't support javascript.
Wnt5a/ß-catenin axis is involved in the downregulation of AT2 lineage by PAI-1.
Jain, Krishan G; Zhao, Runzhen; Liu, Yang; Guo, Xuan; Yi, Guohua; Ji, Hong-Long.
  • Jain KG; Department of Cellular and Molecular Biology, University of Texas at Tyler, Tyler, Texas.
  • Zhao R; Department of Cellular and Molecular Biology, University of Texas at Tyler, Tyler, Texas.
  • Liu Y; Department of Cellular and Molecular Biology, University of Texas at Tyler, Tyler, Texas.
  • Guo X; Department of Computer Science and Engineering, University of North Texas, Denton, Texas.
  • Yi G; Department of Pulmonary Immunology, University of Texas at Tyler, Tyler, Texas.
  • Ji HL; Department of Cellular and Molecular Biology, University of Texas at Tyler, Tyler, Texas.
Am J Physiol Lung Cell Mol Physiol ; 323(5): L515-L524, 2022 Nov 01.
Статья в английский | MEDLINE | ID: covidwho-2108362
ABSTRACT
Failure to regenerate injured alveoli functionally and promptly causes a high incidence of fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-1 (PAI-1) regulates the lineage of alveolar type 2 (AT2) cells for re-alveolarization has not been studied. This study aimed to examine the role of PAI-1-Wnt5a-ß catenin cascades in AT2 fate. Dramatic reduction in AT2 yield was observed in Serpine1Tg mice. Elevated PAI-1 level suppressed organoid number, development efficiency, and total surface area in vitro. Anti-PAI-1 neutralizing antibody restored organoid number, proliferation and differentiation of AT2 cells, and ß-catenin level in organoids. Both Wnt family member 5A (Wnt5a) and Wnt5a-derived N-butyloxycarbonyl hexapeptide (Box5) altered the lineage of AT2 cells. This study demonstrates that elevated PAI-1 regulates AT2 proliferation and differentiation via the Wnt5a/ß catenin cascades. PAI-1 could serve as autocrine signaling for lung injury repair.
Тема - темы
ключевые слова

Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Plasminogen Activator Inhibitor 1 / Beta Catenin / Wnt-5a Protein / COVID-19 Тип исследования: Наблюдательное исследование Пределы темы: Животные Язык: английский Журнал: Am J Physiol Lung Cell Mol Physiol Тематика журнала: Молекулярная биология / Физиология Год: 2022 Тип: Статья

Документы, близкие по теме

MEDLINE

...
LILACS

LIS


Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Plasminogen Activator Inhibitor 1 / Beta Catenin / Wnt-5a Protein / COVID-19 Тип исследования: Наблюдательное исследование Пределы темы: Животные Язык: английский Журнал: Am J Physiol Lung Cell Mol Physiol Тематика журнала: Молекулярная биология / Физиология Год: 2022 Тип: Статья