Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus strains circulating in China from 2020 to 2021.
BMC Vet Res
; 18(1): 392, 2022 Nov 08.
Статья
в английский
| MEDLINE | ID: covidwho-2108779
ABSTRACT
BACKGROUND:
Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, has become the major causative agent of acute gastroenteritis in piglets since 2010 in China.RESULTS:
In the current study, 91 complete spike (S) gene sequences were obtained from PEDV positive samples collected from 17 provinces in China from March 2020 to March 2021. A phylogenetic analysis showed that 92.3% (84 out of 91) of the identified strains belonged to GII subtype, while 7.7% (7 out of 91) were categorized as S-INDEL like strains and grouped within GI-c clade. Based on a recombination analysis, six of S-INDEL like strains were recombinant strains originated from S-INDEL strain FR/001/2014 and virulent strain AJ1102. In addition, PEDV variant strains (CH/GDMM/202012, CH/GXDX/202010 et al) carrying novel insertions (360QGRKS364 and 1278VDVF1281) in the S protein were observed. Furthermore, the deduced amino acid sequences for the S protein showed that multiple amino acid substitutions in the antigenic epitopes in comparison with the vaccine strains.CONCLUSIONS:
In conclusion, these data provide novel molecular evidence on the epidemiology and molecular diversity of PEDV in 2020-2021. This information may help design a strategy for controlling and preventing the prevalence of PEDV variant strains in China.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Swine Diseases
/
Coronavirus Infections
/
Porcine epidemic diarrhea virus
Тип исследования:
Наблюдательное исследование
/
Рандомизированные контролируемые испытания
Темы:
Вакцина
/
Варианты
Пределы темы:
Животные
Страна как тема:
Азия
Язык:
английский
Журнал:
BMC Vet Res
Тематика журнала:
Ветеринария
Год:
2022
Тип:
Статья
Аффилированная страна:
S12917-022-03481-4
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