Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19.
Iran J Immunol
; 19(3): 330-336, 2022 Sep.
Статья
в английский
| MEDLINE | ID: covidwho-2111332
ABSTRACT
Pregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the general population. Possible pathways are I) in patients with COVID-19, cytokine storm defined as the excess release of pro-inflammatory cytokines such as interleukin 1ß (IL-1ß), IL-6, and tumor necrosis factor-α (TNF-α) has been associated with morbidities and an even higher rate of mortality. II) Labor, despite being a term/preterm, has an inflammatory nature, although, inflammation is more prominent in preterm delivery. During labor, different pro-inflammatory cytokines such as IL-1ß, IL-6, and TNF-α are involved which as mentioned, all are crucial role players in the cytokine storm. III) Tissue injury, and during labor, (especially cesarean section) is shown to cause inflammation via pro-inflammatory cytokines release including those involved in the cytokine storm through the activation of nuclear factor κB (NFκB). IV) post-partum hemorrhage with a notable amount of blood loss which can cause significant hypoxemia. In this condition, hypoxia-inducible factor 1α which has a cross-talk with NFκB, leads to the expression of IL-1ß, IL-6, and TNF-α as both angiogenic and pro-inflammatory factors. Considering all the mentioned issues and pathways, we suggest that clinicians be careful about the escalation of the inflammatory status in their pregnant COVID-19 patients during/following labor.
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Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Tumor Necrosis Factor-alpha
/
COVID-19
Тип исследования:
Прогностическое исследование
/
Рандомизированные контролируемые испытания
Пределы темы:
Женщины
/
Люди
/
Новорожденные
/
Беременность
Язык:
английский
Журнал:
Iran J Immunol
Год:
2022
Тип:
Статья
Аффилированная страна:
Iji.2022.93951.2267
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