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Impact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study.
Nakagawara, Kensuke; Chubachi, Shotaro; Namkoong, Ho; Tanaka, Hiromu; Lee, Ho; Azekawa, Shuhei; Otake, Shiro; Fukushima, Takahiro; Morita, Atsuho; Watase, Mayuko; Sakurai, Kaori; Kusumoto, Tatsuya; Asakura, Takanori; Masaki, Katsunori; Kamata, Hirofumi; Ishii, Makoto; Hasegawa, Naoki; Harada, Norihiro; Ueda, Tetsuya; Ueda, Soichiro; Ishiguro, Takashi; Arimura, Ken; Saito, Fukuki; Yoshiyama, Takashi; Nakano, Yasushi; Mutoh, Yoshikazu; Suzuki, Yusuke; Edahiro, Ryuya; Murakami, Koji; Sato, Yasunori; Okada, Yukinori; Koike, Ryuji; Kitagawa, Yuko; Tokunaga, Katsushi; Kimura, Akinori; Imoto, Seiya; Miyano, Satoru; Ogawa, Seishi; Kanai, Takanori; Fukunaga, Koichi.
  • Nakagawara K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Chubachi S; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan. bachibachi472000@live.jp.
  • Namkoong H; Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan. hounamugun@gmail.com.
  • Tanaka H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Lee H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Azekawa S; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Otake S; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Fukushima T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Morita A; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Watase M; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Sakurai K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Kusumoto T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Asakura T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Masaki K; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan.
  • Kamata H; Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan.
  • Ishii M; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Hasegawa N; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Harada N; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Ueda T; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ueda S; Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
  • Ishiguro T; Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
  • Arimura K; Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
  • Saito F; Department of Internal Medicine, JCHO (Japan Community Health Care Organization) Saitama Medical Center, Saitama, Japan.
  • Yoshiyama T; Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
  • Nakano Y; Department of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
  • Mutoh Y; Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
  • Suzuki Y; Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
  • Edahiro R; Department of Internal Medicine, Kawasaki Municipal Ida Hospital, Kawasaki, Japan.
  • Murakami K; Department of Infectious Diseases, Tosei General Hospital, Seto, Japan.
  • Sato Y; Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan.
  • Okada Y; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Koike R; Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kitagawa Y; Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
  • Tokunaga K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
  • Kimura A; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
  • Imoto S; The Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan.
  • Miyano S; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.
  • Ogawa S; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kanai T; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
  • Fukunaga K; Medical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan.
Respir Res ; 23(1): 315, 2022 Nov 15.
Статья в английский | MEDLINE | ID: covidwho-2119361
ABSTRACT

BACKGROUND:

Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients.

METHODS:

This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1 no respiratory symptoms, Group 2 only upper respiratory symptoms, Group 3 only lower respiratory symptoms, and Group 4 both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death.

RESULTS:

Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR] 0.21, 95% confidence interval [CI] 0.11-0.39), while patients in Group 3 had the worst outcomes (OR 3.27, 95% CI 2.43-4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course.

CONCLUSIONS:

Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Люди Язык: английский Журнал: Respir Res Год: 2022 Тип: Статья Аффилированная страна: S12931-022-02222-3

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Люди Язык: английский Журнал: Respir Res Год: 2022 Тип: Статья Аффилированная страна: S12931-022-02222-3