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Vitamin D status and severity of COVID-19.
Nielsen, Nete Munk; Junker, Thor Grønborg; Cohen, Arieh S; Munger, Kassandra L; Stenager, Egon; Ascherio, Alberto; Boding, Lasse; Hviid, Anders.
  • Nielsen NM; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. NMN@ssi.dk.
  • Junker TG; Focused Research Unit in Neurology, Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Aabenraa, Denmark. NMN@ssi.dk.
  • Cohen AS; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Munger KL; Test Center Denmark, Statens Serum Institut, Copenhagen, Denmark.
  • Stenager E; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Ascherio A; Focused Research Unit in Neurology, Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Aabenraa, Denmark.
  • Boding L; Multiple Sclerosis Clinic of Southern Jutland (Sønderborg, Kolding, Esbjerg), Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Sønderborg, Denmark.
  • Hviid A; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sci Rep ; 12(1): 19823, 2022 Nov 17.
Статья в английский | MEDLINE | ID: covidwho-2119366
ABSTRACT
We explored the association between COVID-19 severity and vitamin D status using information from Danish nation-wide health registers, the COVID-19 surveillance database and stored blood samples from the national biobank. 25-hydroxyvitamin D (25(OH)D) was measured using tandem mass spectroscopy. The association between 25(OH)D levels and COVID-19 severity, classified hierarchical as non-hospitalized, hospitalized but not admitted to an intensive care unit (ICU), admitted to ICU, and death, was evaluated by proportional odds ratios (POR) assuming proportionality between the four degrees of severity. Among 447 adults tested SARS-CoV-2 positive in the spring of 2020, low levels of 25(OH)D were associated with a higher risk of severe COVID-19. Thus, odds of experiencing more severe COVID-19 among individuals with insufficient (25 to < 50 nmol/L) and sufficient (≥ 50 nmol/L) 25(OH)D levels were approximately 50% of that among individuals with deficient levels (< 25 nmol/L) (POR = 0.49 (95% CI 0.25-0.94), POR = 0.51 (95% CI 0.27-0.96), respectively). Dividing sufficient vitamin D levels into 50 to < 75 nmol/L and ≥ 75 nmol/L revealed no additional beneficial effect of higher 25(OH)D levels. In this observational study, low levels of 25(OH)D were associated with a higher risk of severe COVID-19. A possible therapeutic role of vitamin D should be evaluated in well-designed interventional studies.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Vitamin D Deficiency / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование Темы: Длинный Ковид Пределы темы: Взрослые / Люди Язык: английский Журнал: Sci Rep Год: 2022 Тип: Статья Аффилированная страна: S41598-022-21513-9

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Vitamin D Deficiency / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование Темы: Длинный Ковид Пределы темы: Взрослые / Люди Язык: английский Журнал: Sci Rep Год: 2022 Тип: Статья Аффилированная страна: S41598-022-21513-9