Sodium alginate-hydrogel coatings on extracorporeal membrane oxygenation for anticoagulation.
Front Cardiovasc Med
; 9: 966649, 2022.
Статья
в английский
| MEDLINE | ID: covidwho-2119615
ABSTRACT
Thromboembolism caused by the use of extracorporeal membrane oxygenation (ECMO) remains common among patients with existing heart diseases and contributes to significant morbidity and mortality during the COVID-19 pandemic. Various surface modification strategies have been proposed, showing that the methacrylated alginate (MA-SA) hydrogel layer is transparent, which aids the observation of the thromboembolism from the inner wall of the tubing. In the combined dynamic and static blood of ECMO tubing inner surface in vitro experiments, it was also demonstrated that the adhesion of blood clots to the surface of vessels was remarkably reduced, and the MA-SA-based hydrogel coating could significantly prolong the activated partial thrombin time and block the endogenous coagulation. The favorable properties of natural polysaccharides of hydrogel coatings make them the best surface material choices to be applied for blood-contacting medical devices and significantly improve anticoagulant performance.
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Тип исследования:
Наблюдательное исследование
/
Прогностическое исследование
Язык:
английский
Журнал:
Front Cardiovasc Med
Год:
2022
Тип:
Статья
Аффилированная страна:
Fcvm.2022.966649
Документы, близкие по теме
MEDLINE
...
LILACS
LIS