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Thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in the United Kingdom.
Burn, Edward; Li, Xintong; Delmestri, Antonella; Jones, Nathan; Duarte-Salles, Talita; Reyes, Carlen; Martinez-Hernandez, Eugenia; Marti, Edelmira; Verhamme, Katia M C; Rijnbeek, Peter R; Strauss, Victoria Y; Prieto-Alhambra, Daniel.
  • Burn E; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain.
  • Li X; Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
  • Delmestri A; Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
  • Jones N; Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
  • Duarte-Salles T; Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
  • Reyes C; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain.
  • Martinez-Hernandez E; Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain.
  • Marti E; Department of Neurology, Hospital Clinic and University of Barcelona, Barcelona, Spain.
  • Verhamme KMC; Hemostasis and Thrombosis Unit, Hematology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain.
  • Rijnbeek PR; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Strauss VY; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Prieto-Alhambra D; Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
Nat Commun ; 13(1): 7167, 2022 Nov 23.
Статья в английский | MEDLINE | ID: covidwho-2133430
ABSTRACT
Population-based studies can provide important evidence on the safety of COVID-19 vaccines. Using data from the United Kingdom, here we compare observed rates of thrombosis and thrombocytopenia following vaccination against SARS-CoV-2 and infection with SARS-CoV-2 with background (expected) rates in the general population. First and second dose cohorts for ChAdOx1 or BNT162b2 between 8 December 2020 and 2 May 2021 in the United Kingdom were identified. A further cohort consisted of people with no prior COVID-19 vaccination who were infected with SARS-Cov-2 identified by a first positive PCR test between 1 September 2020 and 2 May 2021. The fourth general population cohort for background rates included those people in the database as of 1 January 2017. In total, we included 3,768,517 ChAdOx1 and 1,832,841 BNT162b2 vaccinees, 401,691 people infected with SARS-CoV-2, and 9,414,403 people from the general population. An increased risk of venous thromboembolism was seen after first dose of ChAdOx1 (standardized incidence ratio 1.12 [95% CI 1.05 to 1.20]), BNT162b2 (1.12 [1.03 to 1.21]), and positive PCR test (7.27 [6.86 to 7.72]). Rates of cerebral venous sinus thrombosis were higher than otherwise expected after first dose of ChAdOx1 (4.14 [2.54 to 6.76]) and a SARS-CoV-2 PCR positive test (3.74 [1.56 to 8.98]). Rates of arterial thromboembolism after vaccination were no higher than expected but were increased after a SARS-CoV-2 PCR positive test (1.39 [1.21 to 1.61]). Rates of venous thromboembolism with thrombocytopenia were higher than expected after a SARS-CoV-2 PCR positive test (5.76 [3.19 to 10.40]).
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Thrombocytopenia / Thrombosis / Venous Thromboembolism / COVID-19 Vaccines / COVID-19 Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование Темы: Вакцина Пределы темы: Люди Страна как тема: Европа Язык: английский Журнал: Nat Commun Тематика журнала: Биология / Наука Год: 2022 Тип: Статья Аффилированная страна: S41467-022-34668-w

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Thrombocytopenia / Thrombosis / Venous Thromboembolism / COVID-19 Vaccines / COVID-19 Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование Темы: Вакцина Пределы темы: Люди Страна как тема: Европа Язык: английский Журнал: Nat Commun Тематика журнала: Биология / Наука Год: 2022 Тип: Статья Аффилированная страна: S41467-022-34668-w