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Olfactory testing as COVID-19 screening in school children; A prospective cross-sectional study.
Gitomer, Sarah A; Tholen, Kaitlyn; Pickett, Kaci; Mistry, Rakesh D; Beswick, Daniel M; Kaar, Jill L; Herrmann, Brian W.
  • Gitomer SA; Division of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, CO, United States of America.
  • Tholen K; Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States of America.
  • Pickett K; Division of Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, CO, United States of America.
  • Mistry RD; Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States of America.
  • Beswick DM; The Center for Research in Outcomes for Children's Surgery, University of Colorado School of Medicine, Aurora, CO, United States of America.
  • Kaar JL; Section of Emergency Medicine, Children's Hospital Colorado, Aurora, CO, United States of America.
  • Herrmann BW; Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, United States of America.
PLoS One ; 17(11): e0277882, 2022.
Статья в английский | MEDLINE | ID: covidwho-2140669
ABSTRACT

BACKGROUND:

Little is known about olfactory changes in pediatric COVID-19. It is possible that children under-report chemosensory changes on questionnaires, similar to reports in adults. Here, we aim to describe COVID-19-related olfactory dysfunction in outpatient children. We hypothesized that children with COVID-19 will demonstrate abnormal olfaction on smell-identification testing at a higher rate than children with negative COVID-19 testing.

METHODS:

A prospective cross-sectional study was undertaken from June 2020-June 2021 at a tertiary care pediatric hospital. A consecutive sample of 205 outpatients aged 5-21 years undergoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) PCR testing were approached for this study. Patients with prior olfactory dysfunction were excluded. Participants were given a standard COVID-19 symptom questionnaire, a Smell Identification Test (SIT) and home-odorant-based testing within 2 weeks of COVID-19 testing. Prior to study enrollment, power calculation estimated 42 patients to determine difference in rates of SIT results between groups. Data were summarized with descriptive statistics.

RESULTS:

Fifty-one patients underwent smell identification testing (23 positive (45%) and 28 negative (55%) for COVID-19; mean age 12.7 years; 60% female). 92% of all patients denied subjective change in their sense of smell or taste but only 58.8% were normosmic on testing. There was no difference in screening questionnaires or SIT scores between COVID-19 positive and negative groups.

CONCLUSIONS:

Unlike adults, there was no statistical difference in olfactory function between outpatient COVID-19 positive and negative children. Our findings suggest a discrepancy between objective and patient-reported olfactory function in pediatric patients, and poor performance of current screening protocols at detecting pediatric COVID-19.
Тема - темы

Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 / Olfaction Disorders Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Взрослые / Дети / Женщины / Люди / Мужчины Язык: английский Журнал: PLoS One Тематика журнала: Наука / Медицина Год: 2022 Тип: Статья Аффилированная страна: Journal.pone.0277882

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 / Olfaction Disorders Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Пределы темы: Взрослые / Дети / Женщины / Люди / Мужчины Язык: английский Журнал: PLoS One Тематика журнала: Наука / Медицина Год: 2022 Тип: Статья Аффилированная страна: Journal.pone.0277882