Blood hyperviscosity in acute and recent COVID-19 infection.
Clin Hemorheol Microcirc
; 82(2): 149-155, 2022.
Статья
в английский
| MEDLINE | ID: covidwho-2280785
ABSTRACT
BACKGROUND:
Elevated estimated blood viscosity (EBV), derived from hematocrit and globulins, is associated with thrombotic complications, organ failure, and higher mortality in COVID-19 patients. Although informative, EBV does not account for cellular interactions or fibrinogen.OBJECTIVE:
Investigate whether patients with acute and recent COVID-19 have altered whole blood viscosity (WBV) when measured at both high and low shear rates using in vitro blood samples from patients.METHODS:
Cross-sectional study of 58 patients 15 in the intensive care unit with acute COVID-19, 32 convalescent (9â<â8weeks [W] from acute infection, 23â>â8âW), and 11 controls without COVID-19. WBV was measured at high (300âs-1) and low (5âs-1) shear rates (HSR, LSR) using a scanning capillary viscometer.RESULTSAcute and convalescent patientsâ<â8âW had mean WBV at LSR (16.0 centipoise [cP] and 15.1 cP) and HSR (5.1 cP and 4.7 cP). Mean WBV of convalescentâ>â8âW and control patients were 12.3 cP and 13.0 cP at LSR, and 4.1 cP and 4.2 cP at HSR. Acute andâ<â8âW patients had significantly higher WBV at both HSR and LSR compared to patientsâ>â8âW (all p≤0.01). No significant differences in WBV were observed between acute andâ<â8âW patients, or between patientsâ>â8âW and controls.CONCLUSIONS:
Hyperviscosity provides a possible explanation for thrombotic risk in acute and convalescent (<â8âW) patients. These findings have important implications for thromboprophylaxis.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Thrombosis
/
Thrombophilia
/
Venous Thromboembolism
/
COVID-19
Тип исследования:
Наблюдательное исследование
/
Прогностическое исследование
/
Рандомизированные контролируемые испытания
Темы:
Длинный Ковид
Пределы темы:
Люди
Язык:
английский
Журнал:
Clin Hemorheol Microcirc
Тематика журнала:
Болезни системы кровообращения
/
Гематология
Год:
2022
Тип:
Статья
Аффилированная страна:
CH-221429
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