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Outcomes of Living Donor Kidney Transplant After SARS-CoV-2 Infection in Both the Donor and the Recipient: A Multicenter Study.
Kute, Vivek B; Aziz, Feroz; Abraham, Abi; Ray, Deepak S; Pathak, Vivek; Siddini, Vishwanath; Hegde, Umapati; Chauhan, Sanshriti; Meshram, Hari Shankar; Group, Isotstudy.
  • Kute VB; From the Department of Nephrology, Institute of Kidney Diseases and Research Centre, Dr. HL Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Exp Clin Transplant ; 20(10): 908-916, 2022 10.
Статья в английский | MEDLINE | ID: covidwho-2144914
ABSTRACT

OBJECTIVES:

Evidence on living donor kidney transplant procedures when both the donor and recipient have had a history of COVID-19 infection is scarce. MATERIALS AND

METHODS:

We retrospectively explored the protocol, outcomes, and follow-up of 64 donors and recipients of living donor kidney transplant who had recovered from COVID-19. This was a multicenter (n = 12) study from India that included transplants between October 29, 2020, and December 1, 2021. Induction and immunosuppression regimens forthose with different severities of COVID-19 were similar to standard practice.

RESULTS:

COVID-19 clinical severity ranged from asymptomatic/mild (not requiring oxygen therapy) in 49 recipients (77%) and 63 donors (95.4%) and moderate/severe (requiring oxygen therapy) in 15 recipients (23%) and 1 donor (4.6%). Mean wait time±SEM (SD)from firstdocumentednegative reverse transcriptase-polymerase chain reaction testto surgery for recipients and donors was 90.9 ± 9.27 (74.1) and 47 ± 4.5 (29.2) days, respectively. Six episodes (9.3%) of biopsy-proven acute rejection were reported at follow-up of 214 ± 14.8 (119) days and median of 227 (interquartile range, 109-309) days. The locally weighted scatter plot smoothing curve for creatinine during follow-up in donor-recipients pairs showed no trends of increased creatinine in the context of wait time from COVID-19 to transplant surgery. No graft loss, death, reactivation/reinfection, and complications related to surgery or COVID-19 were reported.

CONCLUSIONS:

Our report showed excellent outcomes and follow-up data of living donor kidney transplant in recovered donor-recipient pairs with the standard immunosuppression protocol. To our knowledge, this is the first and the largest study of donor-recipient living donor kidney transplant pairs when both donors and recipients had prior COVID-19.
Тема - темы

Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Kidney Transplantation / COVID-19 Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: Exp Clin Transplant Тематика журнала: Трансплантация Год: 2022 Тип: Статья Аффилированная страна: Ect.2022.0205

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Kidney Transplantation / COVID-19 Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование Пределы темы: Люди Язык: английский Журнал: Exp Clin Transplant Тематика журнала: Трансплантация Год: 2022 Тип: Статья Аффилированная страна: Ect.2022.0205