A comparison of the performance of saliva and nasopharyngeal nucleic acid amplification testing for the detection of SARS-CoV-2 in New Zealand.
N Z Med J
; 135(1559): 53-58, 2022 08 05.
Статья
в английский
| MEDLINE | ID: covidwho-2147482
ABSTRACT
AIM:
To compare detection of SARS-CoV-2 from paired nasopharyngeal swabs (NPS) and saliva using molecular methods in common use for testing swabs in New Zealand.METHOD:
Samples from individuals testing positive for SARS-CoV-2 in Auckland, Wellington and Dunedin were tested at the local laboratories using methods previously established for these sample types.RESULTS:
One hundred and ninety-six paired samples from unique individuals were tested, with 46 (23%) positive from either sample type, of which 43/46 (93%) tested positive from NPS, and 42/46 (91%) from saliva, indicating no significant difference in performance between sample types (p=0.69). The average Δ Ct between saliva and nasopharyngeal swabs overall across the sample set was 0.22 cycles, indicating excellent concordance; however, the difference between NPS and saliva collected from the same individual was quite variable with up to 19 cycles difference between the sample types.CONCLUSION:
We found that saliva is an equivalent sample type to nasopharyngeal swab for the detection of SARS-CoV-2 in our laboratories using multiple assay combinations and is suitable for use as a diagnostic and surveillance test for selected groups of individuals.
Search on Google
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Nucleic Acids
/
COVID-19
Тип исследования:
Диагностическое исследование
/
Экспериментальные исследования
/
Прогностическое исследование
/
Рандомизированные контролируемые испытания
Пределы темы:
Люди
Страна как тема:
Океания
Язык:
английский
Журнал:
N Z Med J
Год:
2022
Тип:
Статья
Аффилированная страна:
Документы, близкие по теме
MEDLINE
...
LILACS
LIS