Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC).
Elife
; 92020 08 17.
Статья
в английский
| MEDLINE | ID: covidwho-2155739
ABSTRACT
Temporal inference from laboratory testing results and triangulation with clinical outcomes extracted from unstructured electronic health record (EHR) provider notes is integral to advancing precision medicine. Here, we studied 246 SARS-CoV-2 PCR-positive (COVIDpos) patients and propensity-matched 2460 SARS-CoV-2 PCR-negative (COVIDneg) patients subjected to around 700,000 lab tests cumulatively across 194 assays. Compared to COVIDneg patients at the time of diagnostic testing, COVIDpos patients tended to have higher plasma fibrinogen levels and lower platelet counts. However, as the infection evolves, COVIDpos patients distinctively show declining fibrinogen, increasing platelet counts, and lower white blood cell counts. Augmented curation of EHRs suggests that only a minority of COVIDpos patients develop thromboembolism, and rarely, disseminated intravascular coagulopathy (DIC), with patients generally not displaying platelet reductions typical of consumptive coagulopathies. These temporal trends provide fine-grained resolution into COVID-19 associated coagulopathy (CAC) and set the stage for personalizing thromboprophylaxis.
ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Pneumonia, Viral
/
Blood Coagulation
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Blood Coagulation Disorders
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Blood Coagulation Tests
/
Coronavirus Infections
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Clinical Laboratory Techniques
/
Betacoronavirus
Тип исследования:
Когортное исследование
/
Диагностическое исследование
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Наблюдательное исследование
/
Прогностическое исследование
/
Качественное исследование
Пределы темы:
Пожилые
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Женщины
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Люди
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Мужчины
/
Middle aged
Язык:
английский
Год:
2020
Тип:
Статья
Аффилированная страна:
ELife.59209
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