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SARS-CoV-2 infection in cancer patients on active therapy after the booster dose of mRNA vaccines.
Di Giacomo, Anna M; Giacobini, Gianluca; Anichini, Gabriele; Gandolfo, Claudia; D'alonzo, Vincenzo; Calabrò, Luana; Lofiego, Maria F; Cusi, Maria G; Maio, Michele.
  • Di Giacomo AM; Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy; University of Siena, Siena, Italy; Italian Network for Tumor Bio-Immunotherapy Foundation Onlus, Italy.
  • Giacobini G; Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy.
  • Anichini G; Virology Unit, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Gandolfo C; Virology Unit, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • D'alonzo V; Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy; University of Siena, Siena, Italy.
  • Calabrò L; Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy.
  • Lofiego MF; Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy.
  • Cusi MG; Virology Unit, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Maio M; Center for Immuno-Oncology, Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Siena, Italy; University of Siena, Siena, Italy; Italian Network for Tumor Bio-Immunotherapy Foundation Onlus, Italy. Electronic address: maio@unisi.it.
Eur J Cancer ; 171: 143-149, 2022 08.
Статья в английский | MEDLINE | ID: covidwho-2178267
ABSTRACT

INTRODUCTION:

The protective role against SARS-CoV-2 infection by the third booster dose of mRNA vaccines in cancer patients with solid malignancies is presently unknown. We prospectively investigated the occurrence of COVID-19 in cancer patients on active therapy after the booster vaccine dose.

METHODS:

Cancer patients on treatment at the Center for Immuno-Oncology (CIO) of the University Hospital of Siena, Italy, and health care workers at CIO who had received a booster third dose of mRNA vaccine entered a systematic follow-up monitoring period to prospectively assess their potential risk of SARS-CoV-2 infection. Serological and microneutralization assay were utilized to assess levels of anti-spike IgG, and of neutralizing antibodies to the SARS-CoV-2 Wild Type, Delta and Omicron variants, respectively, after the booster dose and after negativization of the nasopharyngeal swab for those who had developed COVID-19.

RESULTS:

Ninety cancer patients with solid tumors on active treatment (Cohort 1) and 30 health care workers (Cohort 2) underwent a booster third dose of mRNA vaccine. After the booster dose, the median value of anti-spike IgG was higher (p = 0.009) in patients than in healthy subjects. Remarkably, 11/90 (12%) patients and 11/30 (37%) healthy subjects tested positive to SARS-CoV-2 infection during the monitoring period. Similar levels of anti-spike IgG and of neutralizing antibodies against all the investigated variants, with geometric mean titers of neutralizing antibodies against the Omicron being the lowest were detected after the booster dose and after COVID-19 in both Cohorts.

CONCLUSIONS:

The occurrence of SARS-CoV-2 infection we observed in a sizable proportion of booster-dosed cancer patients and in healthy subjects during the Omicron outbreak indicates that highly specific vaccines against SARS-CoV-2 variants are urgently required.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Vaccines / COVID-19 / Neoplasms Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование / Систематический обзор/метаанализ Темы: Вакцина / Варианты Пределы темы: Люди Язык: английский Журнал: Eur J Cancer Год: 2022 Тип: Статья Аффилированная страна: J.ejca.2022.05.018

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: COVID-19 Vaccines / COVID-19 / Neoplasms Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование / Систематический обзор/метаанализ Темы: Вакцина / Варианты Пределы темы: Люди Язык: английский Журнал: Eur J Cancer Год: 2022 Тип: Статья Аффилированная страна: J.ejca.2022.05.018