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Vaccine Impact and Effectiveness of Meningococcal Serogroup ACWY Conjugate Vaccine Implementation in the Netherlands: A Nationwide Surveillance Study.
Ohm, Milou; Hahné, Susan J M; van der Ende, Arie; Sanders, Elisabeth A M; Berbers, Guy A M; Ruijs, Wilhelmina L M; van Sorge, Nina M; de Melker, Hester E; Knol, Mirjam J.
  • Ohm M; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Hahné SJM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van der Ende A; Department of Medical Microbiology and Infection Prevention and Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam University Medical Center, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Sanders EAM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Berbers GAM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Ruijs WLM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van Sorge NM; Department of Medical Microbiology and Infection Prevention and Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam University Medical Center, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • de Melker HE; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Knol MJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Clin Infect Dis ; 74(12): 2173-2180, 2022 07 06.
Статья в английский | MEDLINE | ID: covidwho-2188401
ABSTRACT

BACKGROUND:

In response to the recent serogroup W invasive meningococcal disease (IMD-W) epidemic in the Netherlands, meningococcal serogroup C (MenC) conjugate vaccination for children aged 14 months was replaced with a MenACWY conjugate vaccination, and a mass campaign targeting individuals aged 14-18 years was executed. We investigated the impact of MenACWY vaccination implementation in 2018-2020 on incidence rates and estimated vaccine effectiveness (VE).

METHODS:

We extracted IMD cases diagnosed between July 2014 and December 2020 from the national surveillance system. We calculated age group-specific incidence rate ratios by comparing incidence rates before (July 2017-March 2018) and after (July 2019-March 2020) MenACWY vaccination implementation. We estimated VE in vaccine-eligible cases using the screening method.

RESULTS:

Overall, the IMD-W incidence rate declined by 61% (95% confidence interval [CI], 40 to 74). It declined by 82% (95% CI, 18 to 96) in the vaccine-eligible age group (individuals aged 15-36 months and 14-18 years) and by 57% (95% CI, 34 to 72) in vaccine-noneligible age groups. VE was 92% (95% CI, -20 to 99.5) in vaccine-eligible toddlers (aged 15-36 months). No IMD-W cases were reported in vaccine-eligible teenagers after the campaign.

CONCLUSIONS:

The MenACWY vaccination program was effective in preventing IMD-W in the target population. The IMD-W incidence reduction in vaccine-noneligible age groups may be caused by indirect effects of the vaccination program. However, disentangling natural fluctuation from vaccine effect was not possible. Our findings encourage the use of toddler and teenager MenACWY vaccination in national immunization programs.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Meningococcal Vaccines / Neisseria meningitidis, Serogroup C / Meningococcal Infections Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Рандомизированные контролируемые испытания Темы: Вакцина Пределы темы: Подростки / Люди Страна как тема: Европа Язык: английский Журнал: Clin Infect Dis Тематика журнала: Инфекционные болезни Год: 2022 Тип: Статья Аффилированная страна: Cid

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Meningococcal Vaccines / Neisseria meningitidis, Serogroup C / Meningococcal Infections Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Рандомизированные контролируемые испытания Темы: Вакцина Пределы темы: Подростки / Люди Страна как тема: Европа Язык: английский Журнал: Clin Infect Dis Тематика журнала: Инфекционные болезни Год: 2022 Тип: Статья Аффилированная страна: Cid