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COVID-19 vaccination efficacy in numbers including SARS-CoV-2 variants and age comparison: a meta-analysis of randomized clinical trials.
Sobczak, Marharyta; Pawliczak, Rafal.
  • Sobczak M; Department of Immunopathology, Faculty of Medicine, Division of Biomedical Science, Medical University of Lodz, st. Zeligowskiego 7/9, 90-752, Lodz, Poland.
  • Pawliczak R; Department of Immunopathology, Faculty of Medicine, Division of Biomedical Science, Medical University of Lodz, st. Zeligowskiego 7/9, 90-752, Lodz, Poland. rafal.pawliczak@csk.umed.lodz.pl.
Ann Clin Microbiol Antimicrob ; 21(1): 32, 2022 Jul 03.
Статья в английский | MEDLINE | ID: covidwho-2196304
ABSTRACT

BACKGROUND:

New vaccines are being developed to fight the ongoing COVID-19 pandemic. In our study we compared the efficacy of COVID-19 vaccines to prevent COVID-19-related infections and mortality.

METHODS:

17 randomized clinical trials of COVID-19 vaccines were included after search in databases. We compared COVID-19 vaccines based on symptomatic and severe infections, number of deaths and hospitalizations related to COVID-19. Also, we analyzed the efficacy of COVID-19 against different variants of SARS-CoV-2 as well as according to different age groups. Random effects model using Mantel-Haenzeal method was used to pool relative risk (RR).

RESULTS:

Our meta-analysis shows that full vaccination could decrease not only the risk of symptomatic or severe COVID-19, the risk of hospitalization and death caused by COVID-19. COVID-19 vaccines were also effective against variants of SARS-CoV-2 (RR = 0.36; 95% CI [0.25; 0.53], p < 0.0001). However, efficacy of vaccination varied in COVID-19 variant-dependent manner. Moreover, the analysis in different age groups showed that COVID-19 vaccines had the similar

results:

the risk was slightly lower in adults compared to elderly cohort [Formula see text] 65 years) (RR = 0.16, 95% CI [0.11; 0.23]) and (RR = 0.19, 95% CI [0.12; 0.30]), respectively.

CONCLUSIONS:

Data obtained from clinical trials of COVID-19 vaccines looks promising, in order to fully investigate efficacy of the vaccines further clinical examination is required especially considering new SARS-CoV-2 variants.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Viral Vaccines / COVID-19 Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания / Отзывы Темы: Вакцина / Варианты Пределы темы: Взрослые / Пожилые / Люди Язык: английский Журнал: Ann Clin Microbiol Antimicrob Тематика журнала: Микробиология / Лекарственная терапия Год: 2022 Тип: Статья Аффилированная страна: S12941-022-00525-3

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Viral Vaccines / COVID-19 Тип исследования: Когортное исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания / Отзывы Темы: Вакцина / Варианты Пределы темы: Взрослые / Пожилые / Люди Язык: английский Журнал: Ann Clin Microbiol Antimicrob Тематика журнала: Микробиология / Лекарственная терапия Год: 2022 Тип: Статья Аффилированная страна: S12941-022-00525-3