Risk factors for community-acquired respiratory infections in a non-pandemic context: Secondary analysis of the PRIMIT study.
PLoS One
; 17(11): e0277201, 2022.
Статья
в английский
| MEDLINE | ID: covidwho-2197029
ABSTRACT
OBJECTIVES:
Respiratory tract infection (RTI) incidence varies between people, but little is known about why. The aim of this study is therefore to identify risk factors for acquiring RTIs.METHODS:
We conducted a secondary analysis of 16,908 participants in the PRIMIT study, a pre-pandemic randomised trial showing handwashing reduced incidence of RTIs in the community. Data was analysed using multivariable logistic regression analyses of self-reported RTI acquisition.RESULTS:
After controlling for handwashing, RTI in the previous year (1 to 2 RTIs adjusted OR 1.96, 95% CI 1.79 to 2.13, p<0.001; 3 to 5 RTIs aOR 3.89, 95% CI 3.49 to 4.33, p<0.001; ≥6 RTIs OR 5.52, 95% CI 4.37 to 6.97, p<0.001); skin conditions that prevent handwashing (aOR 1.39, 95% CI 1.24 to 1.55, p<0.001); children under 16 years in the household (aOR 1.27, 95% CI 1.12, 1.43, p<0.001); chronic lung condition (aOR 1.16, 95% CI 1.02 to 1.32, p = 0.026); female sex (aOR 1.10, 95% CI 1.03 to 1.18, p = 0.005), and post-secondary education (aOR 1.09, 95% CI 1.02 to 1.17, p = 0.01) increased the likelihood of RTI. Those over the age of 65 years were less likely to develop an infection (aOR 0.89, 95% CI 0.82 to 0.97, p = 0.009). Household crowding and influenza vaccination do not influence RTI acquisition. A post-hoc exploratory analysis found no evidence these subgroups differentially benefited from handwashing.CONCLUSIONS:
Previous RTIs, chronic lung conditions, skin conditions that prevent handwashing, and the presence of household children predispose to RTI acquisition. Further research is needed to understand how host and microbial factors explain the relationship between previous and future RTIs.
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Respiratory Tract Infections
/
Community-Acquired Infections
Тип исследования:
Экспериментальные исследования
/
Наблюдательное исследование
/
Прогностическое исследование
/
Рандомизированные контролируемые испытания
Темы:
Вакцина
Пределы темы:
Пожилые
/
Дети
/
Женщины
/
Люди
Язык:
английский
Журнал:
PLoS One
Тематика журнала:
Наука
/
Медицина
Год:
2022
Тип:
Статья
Аффилированная страна:
Journal.pone.0277201
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