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Clinical profile of patients infected with suspected SARS-CoV-2 Omicron variant of concern, Tamil Nadu, India, December 2021-January 2022.
Raju, Mohan Kumar; Vivian Thangaraj, Jeromie Wesley; Selvavinayagam, T S; Somasundaram, A; Parthipan, K; Sivadoss, Raju; Sabarinathan, R; Subramaniam, Sudharshini; A Rozario, Amanda G; Rani, Sudha D; Suganya, E; Murhekar, Manoj V.
  • Raju MK; School of Public Health, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Vivian Thangaraj JW; Department of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Selvavinayagam TS; Department of Health & Family Welfare, Directorate of Public Health & Preventive Medicine, Government of Tamil Nadu, Chennai, Tamil Nadu, India.
  • Somasundaram A; Department of Health & Family Welfare, Directorate of Public Health & Preventive Medicine, Government of Tamil Nadu, Chennai, Tamil Nadu, India.
  • Parthipan K; Department of Health & Family Welfare, Directorate of Public Health & Preventive Medicine, Government of Tamil Nadu, Chennai, Tamil Nadu, India.
  • Sivadoss R; Department of Health & Family Welfare, Directorate of Public Health & Preventive Medicine, Government of Tamil Nadu, Chennai, Tamil Nadu, India.
  • Sabarinathan R; Department of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Subramaniam S; Department of Community Medicine, Madras Medical College, Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.
  • A Rozario AG; Department of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Rani SD; Department of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Suganya E; Department of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Murhekar MV; Department of Epidemiology & Biostatistics, ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Indian J Med Res ; 155(1): 165-170, 2022 01.
Статья в английский | MEDLINE | ID: covidwho-2201739
ABSTRACT
Background &

objectives:

COVID-19 cases have been rising rapidly in countries where the SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529) has been reported. We conducted a study to describe the epidemiological and clinical characteristics and outcomes of COVID-19 patients with 'S' gene target failure (SGTF, suspected Omicron). Furthermore, their clinical outcomes with COVID-19 patients with non-SGTF (non-Omicron) were also compared.

Methods:

This study was conducted in Tamil Nadu, India, between December 14, 2021 and January 7, 2022 among patients who underwent reverse transcription-PCR testing for SARS-CoV-2 in four laboratories with facilities for S gene screening. Consecutively selected COVID-19 patients with SGTF were telephonically contacted, seven and 14 days respectively after their date of positive result to collect information on the socio-demographic characteristics, previous history of COVID-19, vaccination status and clinical course of illness along with treatment details. To compare their outcomes with non-SGTF patients, one randomly suspected non-Omicron case for every two suspected Omicron cases from the line-list were selected, matching for the date of sample collection and the testing laboratory.

Results:

A total of 1175 SGTF COVID-19 patients were enrolled for this study. Almost 6 per cent (n=72) reported a history of previous infection. 141 (13.5%) suspected Omicron cases were non-vaccinated, while 148 (14.2%) and 703 (67.4%) had received valid one and two doses of COVID-19 vaccines, respectively. Predominant symptoms reported included fever (n=508, 43.2%), body pain (n=275, 23.4%), running nose (n=261, 22.2%) and cough (n=249, 21.2%). Five (0.4%) of the 1175 suspected Omicron cases required oxygen supplementation as compared to ten (1.6%) of the 634 suspected non-Omicron cases. No deaths were reported among omicron suspects, whereas there were four deaths among suspected non-Omicron cases. Interpretation &

conclusions:

Majority of the suspected Omicron cases had a mild course of illness. The overall severity of these cases was less compared to the suspected non-Omicron cases.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: SARS-CoV-2 / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Вакцина / Варианты Пределы темы: Люди Страна как тема: Азия Язык: английский Журнал: Indian J Med Res Год: 2022 Тип: Статья Аффилированная страна: Ijmr.ijmr_312_22

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: SARS-CoV-2 / COVID-19 Тип исследования: Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Вакцина / Варианты Пределы темы: Люди Страна как тема: Азия Язык: английский Журнал: Indian J Med Res Год: 2022 Тип: Статья Аффилированная страна: Ijmr.ijmr_312_22