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Structural Profiles of SARS-CoV-2 Variants in India.
Chakraborti, Soumyananda; Gill, Jasmita; Goswami, Ritu; Kumar, Sanjeev; Chandele, Anmol; Sharma, Amit.
  • Chakraborti S; National Institute of Malaria Research, New Delhi, 110077, India. soumya@mrcindia.org.
  • Gill J; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, UP, 201002, India. soumya@mrcindia.org.
  • Goswami R; National Institute of Malaria Research, New Delhi, 110077, India. jasmita.gill@gmail.com.
  • Kumar S; National Institute of Malaria Research, New Delhi, 110077, India.
  • Chandele A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, UP, 201002, India.
  • Sharma A; ICGEB-Emory Vaccine Center, Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, 110067, India.
Curr Microbiol ; 80(1): 1, 2022 Nov 22.
Статья в английский | MEDLINE | ID: covidwho-2282221
ABSTRACT
India was severely affected by several waves of SARS-CoV-2 infection that occurred during April-June 2021 (second wave) and December 2021-January 2022 (third wave) and thereafter, resulting in >10 million new infections and a significant number of deaths. Global Initiative on Sharing Avian Influenza Data database was used to collect the sequence information of ~10,000 SARS-CoV-2 patients from India and our sequence analysis identified three variants B.1.1.7 (alpha, α), B1.617.2 (delta, Δ), B.1.1.529 (Omicron, Oo) and one Omicron sub-variant BA.2.75 as the primary drivers for SARS-CoV-2 waves in India. Structural visualization and analysis of important mutations of alpha, delta, Omicron and its sub-variants of SARS-CoV-2 Receptor-Binding Domain (RBD) was performed and our analysis clearly shows that mutations occur throughout the RBD, including the RBD surface responsible for human angiotensin-converting enzyme 2 (hACE-2) receptor-binding. A comparison between alpha, delta and omicron variants/sub-variants reveals many omicron mutations in the hACE-2 binding site and several other mutations within 5 Å of this binding region. Further, computational analysis highlights the importance of electrostatic interactions in stabilizing RBD-hACE-2-binding, especially in the omicron variant. Our analysis explores the likely role of key alpha, delta and omicron mutations on binding with hACE-2. Taken together, our study provides novel structural insights into the implications of RBD mutations in alpha, delta and omicron and its sub-variants that were responsible for India's SARS-CoV-2 surge.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: SARS-CoV-2 / COVID-19 Темы: Варианты Пределы темы: Животные / Люди Язык: английский Журнал: Curr Microbiol Год: 2022 Тип: Статья Аффилированная страна: S00284-022-03094-y

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: SARS-CoV-2 / COVID-19 Темы: Варианты Пределы темы: Животные / Люди Язык: английский Журнал: Curr Microbiol Год: 2022 Тип: Статья Аффилированная страна: S00284-022-03094-y