The End of Endomyocardial Biopsy?: A Practical Guide for Noninvasive Heart Transplant Rejection Surveillance.
JACC Heart Fail
; 11(3): 263-276, 2023 03.
Статья
в английский
| MEDLINE | ID: covidwho-2263094
ABSTRACT
Noninvasive heart transplant rejection surveillance using gene expression profiling (GEP) to monitor immune activation is widely used among heart transplant programs. With the new development of donor-derived cell-free DNA (dd-cfDNA) assays, more programs are transitioning to a predominantly noninvasive rejection surveillance protocol with a reduced frequency of endomyocardial biopsies. As a result, many practical questions arise that potentially delay implementation of these valuable new tools. The purpose of this review is to provide practical guidance for clinicians transitioning toward a less invasive acute rejection monitoring protocol after heart transplantation, and to answer 10 common questions about the GEP and dd-cfDNA assays. Evidence supporting GEP and dd-cfDNA testing is reviewed, as well as guidance on test interpretation and future directions.
ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Heart Transplantation
/
Cell-Free Nucleic Acids
/
Heart Failure
Тип исследования:
Диагностическое исследование
Пределы темы:
Люди
Язык:
английский
Журнал:
JACC Heart Fail
Год:
2023
Тип:
Статья
Аффилированная страна:
J.jchf.2022.11.002
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