Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors.
Eur J Med Chem
; 244: 114791, 2022 Dec 15.
Статья
в английский
| MEDLINE | ID: covidwho-2284106
ABSTRACT
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway serves as a pivotal mediator of innate immunity by triggering the secretion of type I interferons and other proinflammatory cytokines. In view of the immune-related diseases caused by abnormal activity of the cGAS-STING signaling pathway, considerable progress in this field has encouraged the discovery of cGAS-STING inhibitors in the past five years. In this review, we will focus on the link between the cGAS-STING signaling pathway and autoimmune and inflammatory disorders, summarize the development and optimization of cGAS-STING signaling pathway inhibitors, discuss the therapeutic effects on inflammatory diseases and propose suggestions and insights for future exploitation.
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Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Chemistry, Pharmaceutical
/
Membrane Proteins
Язык:
английский
Журнал:
Eur J Med Chem
Год:
2022
Тип:
Статья
Аффилированная страна:
J.ejmech.2022.114791
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