The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain.
J Infect
; 87(2): 103-110, 2023 08.
Статья
в английский
| MEDLINE | ID: covidwho-2318208
ABSTRACT
BACKGROUND:
Human metapneumovirus (HMPV) is an important aetiologic agent of respiratory tract infection (RTI). This study aimed to describe the prevalence, genetic diversity, and evolutionary dynamics of HMPV.METHODS:
Laboratory-confirmed HMPV were characterised based on partial-coding G gene sequences with MEGA.v6.0. WGS was performed with Illumina, and evolutionary analyses with Datamonkey and Nextstrain.RESULTS:
HMPV prevalence was 2.5%, peaking in February-April and with an alternation in the predominance of HMPV-A and -B until the emergence of SARS-CoV-2, not circulating until summer and autumn-winter 2021, with a higher prevalence and with the almost only circulation of A2c111dup. G and SH proteins were the most variable, and 70% of F protein was under negative selection. Mutation rate of HMPV genome was 6.95 × 10-4 substitutions/site/year.CONCLUSION:
HMPV showed a significant morbidity until the emergence of SARS-CoV-2 pandemic in 2020, not circulating again until summer and autumn 2021, with a higher prevalence and with almost the only circulation of A2c111dup, probably due to a more efficient immune evasion mechanism. The F protein showed a very conserved nature, supporting the need for steric shielding. The tMRCA showed a recent emergence of the A2c variants carrying duplications, supporting the importance of virological surveillance.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Respiratory Tract Infections
/
Paramyxoviridae Infections
/
Metapneumovirus
/
COVID-19
Тип исследования:
Изучение этиологии
/
Экспериментальные исследования
/
Наблюдательное исследование
Темы:
Варианты
Пределы темы:
Люди
/
Грудные дети
Страна как тема:
Европа
Язык:
английский
Журнал:
J Infect
Год:
2023
Тип:
Статья
Аффилированная страна:
J.jinf.2023.05.004
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