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Air dispersal of respiratory viruses other than severe acute respiratory coronavirus virus 2 (SARS-CoV-2) and the implication on hospital infection control.
Wong, Shuk-Ching; Chan, Veronica Wing-Man; AuYeung, Christine Ho-Yan; Chen, Jonathan Hon-Kwan; Yip, Cyril Chik-Yan; So, Simon Yung-Chun; Li, Xin; Lung, David Christopher; Tsang, Anita Man-Ching; To, Kelvin Kai-Wang; Yuen, Kwok-Yung; Cheng, Vincent Chi-Chung.
  • Wong SC; Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, China.
  • Chan VW; Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, China.
  • AuYeung CH; Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, China.
  • Chen JH; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
  • Yip CC; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
  • So SY; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
  • Li X; Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Lung DC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China.
  • Tsang AM; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China.
  • To KK; Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
  • Yuen KY; Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Cheng VC; Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Infect Control Hosp Epidemiol ; : 1-6, 2022 Jul 11.
Статья в английский | MEDLINE | ID: covidwho-2327113
ABSTRACT

BACKGROUND:

Air dispersal of respiratory viruses other than SARS-CoV-2 has not been systematically reported. The incidence and factors associated with air dispersal of respiratory viruses are largely unknown.

METHODS:

We performed air sampling by collecting 72,000 L of air over 6 hours for pediatric and adolescent patients infected with parainfluenza virus 3 (PIF3), respiratory syncytial virus (RSV), rhinovirus, and adenovirus. The patients were singly or 2-patient cohort isolated in airborne infection isolation rooms (AIIRs) from December 3, 2021, to January 26, 2022. The viral load in nasopharyngeal aspirates (NPA) and air samples were measured. Factors associated with air dispersal were investigated and analyzed.

RESULTS:

Of 20 singly isolated patients with median age of 30 months (range, 3 months-15 years), 7 (35%) had air dispersal of the viruses compatible with their NPA results. These included 4 (40%) of 10 PIF3-infected patients, 2 (66%) of 3 RSV-infected patients, and 1 (50%) of 2 adenovirus-infected patients. The mean viral load in their room air sample was 1.58×103 copies/mL. Compared with 13 patients (65%) without air dispersal, these 7 patients had a significantly higher mean viral load in their NPA specimens (6.15×107 copies/mL vs 1.61×105 copies/mL; P < .001). Another 14 patients were placed in cohorts as 7 pairs infected with the same virus (PIF3, 2 pairs; RSV, 3 pairs; rhinovirus, 1 pair; and adenovirus, 1 pair) in double-bed AIIRs, all of which had air dispersal. The mean room air viral load in 2-patient cohorts was significantly higher than in rooms of singly isolated patients (1.02×104 copies/mL vs 1.58×103 copies/mL; P = .020).

CONCLUSION:

Air dispersal of common respiratory viruses may have infection prevention and public health implications.

Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование Язык: английский Журнал: Infect Control Hosp Epidemiol Тематика журнала: Инфекционные болезни / Сестринское дело / Эпидемиология / Больницы Год: 2022 Тип: Статья Аффилированная страна: Ice.2022.186

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Тип исследования: Когортное исследование / Наблюдательное исследование / Прогностическое исследование Язык: английский Журнал: Infect Control Hosp Epidemiol Тематика журнала: Инфекционные болезни / Сестринское дело / Эпидемиология / Больницы Год: 2022 Тип: Статья Аффилированная страна: Ice.2022.186