EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count.
Int J Infect Dis
; 104: 315-319, 2021 Mar.
Статья
в английский
| MEDLINE | ID: covidwho-988038
ABSTRACT
OBJECTIVES:
The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity.METHODS:
A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry.RESULTS:
Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p<0.05). In contrast, B cell count was significantly increased in ICU patients (p=0.0172).CONCLUSIONS:
A correlation between reduced CD8+ T cells and NK counts, EBV DNA levels and COVID-19 severity was observed. Other opportunistic viral infections were not observed. The relationship between EBV load and COVID-19 severity should be further evaluated in longitudinal studies.ключевые слова
Полный текст:
Имеется в наличии
Коллекция:
Международные базы данных
база данных:
MEDLINE
Основная тема:
Herpesvirus 4, Human
/
Viral Load
/
Epstein-Barr Virus Infections
/
SARS-CoV-2
/
COVID-19
Тип исследования:
Когортное исследование
/
Диагностическое исследование
/
Экспериментальные исследования
/
Наблюдательное исследование
/
Прогностическое исследование
/
Рандомизированные контролируемые испытания
Темы:
Длинный Ковид
Пределы темы:
Пожилые
/
Женщины
/
Люди
/
Мужчины
/
Middle aged
Язык:
английский
Журнал:
Int J Infect Dis
Тематика журнала:
Инфекционные болезни
Год:
2021
Тип:
Статья
Аффилированная страна:
J.ijid.2020.12.051
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