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EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count.
Paolucci, Stefania; Cassaniti, Irene; Novazzi, Federica; Fiorina, Loretta; Piralla, Antonio; Comolli, Giuditta; Bruno, Raffaele; Maserati, Renato; Gulminetti, Roberto; Novati, Stefano; Mojoli, Francesco; Baldanti, Fausto.
  • Paolucci S; Molecular Virology Unit, Microbiology and VirologyDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Cassaniti I; Molecular Virology Unit, Microbiology and VirologyDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Novazzi F; Molecular Virology Unit, Microbiology and VirologyDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Fiorina L; Laboratorio Genetica - Trapiantologia e Malattie Cardiovascolari, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Piralla A; Molecular Virology Unit, Microbiology and VirologyDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Comolli G; Molecular Virology Unit, Microbiology and VirologyDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Experimental ResearchLaboratories, Biotechnology Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Bruno R; Infectious DiseaseDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Maserati R; Infectious DiseaseDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Gulminetti R; Infectious DiseaseDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Novati S; Infectious DiseaseDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Mojoli F; Anesthesia and Intensive Care, Emergency Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Baldanti F; Molecular Virology Unit, Microbiology and VirologyDepartment, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Electronic address: f.baldanti@smatteo.pv.it.
Int J Infect Dis ; 104: 315-319, 2021 Mar.
Статья в английский | MEDLINE | ID: covidwho-988038
ABSTRACT

OBJECTIVES:

The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity.

METHODS:

A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry.

RESULTS:

Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p<0.05). In contrast, B cell count was significantly increased in ICU patients (p=0.0172).

CONCLUSIONS:

A correlation between reduced CD8+ T cells and NK counts, EBV DNA levels and COVID-19 severity was observed. Other opportunistic viral infections were not observed. The relationship between EBV load and COVID-19 severity should be further evaluated in longitudinal studies.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Herpesvirus 4, Human / Viral Load / Epstein-Barr Virus Infections / SARS-CoV-2 / COVID-19 Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Длинный Ковид Пределы темы: Пожилые / Женщины / Люди / Мужчины / Middle aged Язык: английский Журнал: Int J Infect Dis Тематика журнала: Инфекционные болезни Год: 2021 Тип: Статья Аффилированная страна: J.ijid.2020.12.051

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Herpesvirus 4, Human / Viral Load / Epstein-Barr Virus Infections / SARS-CoV-2 / COVID-19 Тип исследования: Когортное исследование / Диагностическое исследование / Экспериментальные исследования / Наблюдательное исследование / Прогностическое исследование / Рандомизированные контролируемые испытания Темы: Длинный Ковид Пределы темы: Пожилые / Женщины / Люди / Мужчины / Middle aged Язык: английский Журнал: Int J Infect Dis Тематика журнала: Инфекционные болезни Год: 2021 Тип: Статья Аффилированная страна: J.ijid.2020.12.051