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Cetylpyridinium chloride-containing mouthwashes reduce in vitro SARS-CoV-2 infectivity (preprint)
biorxiv; 2020.
Препринт
в английский
| bioRxiv | ID: ppzbmed-10.1101.2020.12.21.423779
ABSTRACT
Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity present in these oral rinses and their exact mechanism of action remain unknown. Here we show that Cetylpyridinium chloride (CPC), a quaternary ammonium compound present in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting viral fusion with target cells. We also found that CPC and CPC-containing mouth rinses decreased a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. CPC-containing mouth rinses could represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals.
Полный текст:
Имеется в наличии
Коллекция:
Препринты
база данных:
bioRxiv
Основная тема:
Severe Acute Respiratory Syndrome
Язык:
английский
Год:
2020
Тип:
Препринт
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