This article is a Preprint
Preprints are preliminary research reports that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Preprints posted online allow authors to receive rapid feedback and the entire scientific community can appraise the work for themselves and respond appropriately. Those comments are posted alongside the preprints for anyone to read them and serve as a post publication assessment.
Vaccine-elicited B and T cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients (preprint)
medrxiv; 2023.
Препринт
в английский
| medRxiv | ID: ppzbmed-10.1101.2023.01.25.23284971
ABSTRACT
The protection afforded by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to individuals with chronic lung disease is not well established. To understand how chronic lung disease impacts SARS-CoV-2 vaccine-elicited immunity we performed deep immunophenotyping of the humoral and cell mediated SARS-CoV-2 vaccine response in an investigative cohort of vaccinated patients with diverse pulmonary conditions including asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Compared to healthy controls, 48% of vaccinated patients with chronic lung diseases had reduced antibody titers to the SARS-CoV-2 vaccine antigen as early as 3-4 months after vaccination, correlating with decreased vaccine-specific memory B cells. Vaccine-specific CD4 and CD8 T cells were also significantly reduced in patients with asthma, COPD, and a subset of ILD patients compared to healthy controls. These findings reveal the complex nature of vaccine-elicited immunity in high-risk patients with chronic lung disease.
Полный текст:
Имеется в наличии
Коллекция:
Препринты
база данных:
medRxiv
Основная тема:
Asthma
/
Lung Diseases, Interstitial
/
Coronavirus Infections
/
Pulmonary Disease, Chronic Obstructive
/
Severe Acute Respiratory Syndrome
Язык:
английский
Год:
2023
Тип:
Препринт
Документы, близкие по теме
MEDLINE
...
LILACS
LIS