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Resultados  1-12 de 1.382

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.

Autor(es): Ilyushina, Natalia A; Komatsu, Takashi E; Ince, William L; Donaldson, Eric F; Lee, Nicolette; O'Rear, Julian J; Donnelly, Raymond P
Fonte: Virol J;16(1): 149, 2019 11 29.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31783761
Resumo: BACKGROUND: Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the influenza hemagglutinin (HA) protein. Numerous HA substitutions have been identified in nonclinical NAI resistance-selection experiments as well as in clinical specimens from NAI treatment or surveillance studies. These mutations are listed in th (mais)

Perfil clínico-epidemiológico de las defunciones por influenza con antecedente de vacunación oportuna, México 2010-2018.

Autor(es): Kuri-Morales, Pablo Antonio; Castillo-Flores, Guadalupe Díaz Del; Castañeda-Prado, Andrés; Pacheco-Montes, Salma Rosario
Fonte: Gac Med Mex;155(5): 457-463, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31695227
Resumo: Introduction: Influenza epidemics are of higher risk at the extremes of life and in people with comorbidities. Effective -vaccination prevents the occurrence of serious cases and decreases mortality. Objective: To describe deaths from influenza with a history of timely vaccination, from the 2010 to the 2018 season in Mexico. Method: Cross-sectional, descriptive study where the Influenza Epidemiological Surveillance System database was used. Results: From 2010 to 2018, 65 vaccinated individu (mais)

Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza.

Autor(es): Mawatari, Momoko; Saito, Reiko; Hibino, Akinobu; Kondo, Hiroki; Yagami, Ren; Odagiri, Takashi; Tanabe, Ikumi; Shobugawa, Yugo
Fonte: PLoS One;14(11): e0224683, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31697721
Resumo: BACKGROUND: Neuraminidase inhibitors (NAIs) effectively treat influenza. The clinical effectiveness of four NAIs (oseltamivir, zanamivir, laninamivir, and peramivir) was evaluated against influenza A/H1N1pdm09, A/H3N2, and B viruses. Additionally, fever duration in patients infected with oseltamivir-resistant influenza A/H1N1pdm09 with the H275Y mutation was evaluated. METHODS: Patients aged <20 years who visited outpatient clinics in Japan with influenza-like illnesses were enrolled during (mais)

Oseltamivir Is Effective against 1918 Influenza Virus Infection of Macaques but Vulnerable to Escape.

Autor(es): Feldmann, Friederike; Kobasa, Darwyn; Embury-Hyatt, Carissa; Grolla, Allen; Taylor, Tracy; Kiso, Maki; Kakugawa, Satoshi; Gren, Jason; Jones, Steven M; Kawaoka, Yoshihiro; Feldmann, Heinz
Fonte: mBio;10(5)2019 10 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31641086
Resumo: The 1918 influenza virus, subtype H1N1, was the causative agent of the most devastating pandemic in the history of infectious diseases. In vitro studies have confirmed that extreme virulence is an inherent property of this virus. Here, we utilized the macaque model for evaluating the efficacy of oseltamivir phosphate against the fully reconstructed 1918 influenza virus in a highly susceptible and relevant disease model. Our findings demonstrate that oseltamivir phosphate is effective in pre (mais)

Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus-infected mice.

Autor(es): Takahashi, E; Sawabuchi, T; Kimoto, T; Sakai, S; Kido, H
Fonte: J Dairy Sci;102(11): 9559-9569, 2019 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31495632
Resumo: Antiviral neuraminidase inhibitors, such as oseltamivir, zanamivir, and peramivir, are widely used for treatment of influenza virus infection. We reported previously that oseltamivir inhibits the viral growth cycle, ameliorates symptoms, and reduces viral antigen quantities. Suppressed viral antigen production, however, induces a reduction of acquired antiviral humoral immunity, and increases the incidence of re-infection rate in the following year. To achieve effective treatment of influen (mais)

Molecular characterization of influenza A(H1N1)pdm09 viruses circulating at various geographical locations in India, 2017.

Autor(es): Potdar, Varsha; Vijay, Neetu; Gupta, Nivedita; Arunkumar, G; Borkakoty, Bishwajyoti; Malhotra, Bharti; Rabha, Debajit; Hinge, Dilip; Kaur, Harmanmeet; Chadha, Mandeep
Fonte: Indian J Med Res;149(6): 783-789, 2019 06.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31496532
Resumo: Background & objectives: Influenza virological surveillance is an essential tool for the early detection of novel genetic variants of epidemiologic and clinical significance. This study was aimed to genetically characterize A(H1N1)pdm09 virus circulating in 2017 and to compare it with the global data. Methods: The regional/State Viral Research and Diagnostic Laboratories (VRDLs) provided influenza diagnosis for referred clinical samples and shared influenza A(H1N1)pdm09 positives with the I (mais)

Growth activation of influenza virus by trypsin and effect of T-705 (favipiravir) on trypsin-optimized growth condition.

Autor(es): Daikoku, T; Okuda, T; Kawai, M; Morita, N; Tanaka, T; Takemoto, M; Fukuda, Y; Takahashi, K; Nomura, N; Shiraki, K
Fonte: Acta Virol;63(3): 309-315, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31507197
Resumo: Influenza virus is activated by proteolytic cleavage of hemagglutinin by trypsin. After determining the optimal trypsin concentration, intracellular and extracellular influenza A/PR/8/34 (H1N1) and A/Victoria/361/2011 (H3N2) virus productions were compared in cultures treated with T-705 (favipiravir) and GS 4071 (an active form of oseltamivir). Although both drugs efficiently inhibited extracellular viral RNA release in a dose-dependent manner, T-705 inhibited it to the level of the inoculu (mais)

Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection.

Autor(es): Geng, Zi-Kai; Li, Ya-Qun; Cui, Qing-Hua; DU, Rui-Kun; Tian, Jing-Zhen
Fonte: Chin J Nat Med;17(9): 650-662, 2019 Sep.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31526500
Resumo: Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate anti-IAV activity in vitro. GGD was more effective when given before the viral infection and targeted the viral attachment and replication stages rather than the internalization (mais)

MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33.

Autor(es): Wong, Ho Him; Fung, Kevin; Nicholls, John M
Fonte: Emerg Microbes Infect;8(1): 1428-1437, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31560252
Resumo: Switching of receptor binding preference has been widely considered as one of the necessary mutations for avian influenza viruses, enabling efficient transmissions between human hosts. By stably overexpressing B4GalNT2 gene in MDCK cells, surface α2,3-siallylactose receptors were modified without affecting α2,6-receptor expression. The cell line MDCK-B4GalNT2 was used as a tool to screen for α2,3-receptor requirements in a panel of influenza viruses with previously characteri (mais)

Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza.

Autor(es): Huang, Ching-Tai; Hung, Chen-Yiu; Hseih, Yu-Chia; Chang, Chia-Shiang; Velu, Arul Balaji; He, Yueh-Chia; Huang, Yu-Lin; Chen, Ting-An; Chen, Tse-Ching; Lin, Chun-Yen; Lin, Yung-Chang; Shih, Shin-Ru; Dutta, Avijit
Fonte: Phytomedicine;64: 152904, 2019 Nov.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31454654
Resumo: BACKGROUND: Millions of people are infected by the influenza virus worldwide every year. Current selections of anti-influenza agents are limited and their effectiveness and drug resistance are still of concern. PURPOSE: Investigation on in vitro and in vivo effect of aloin from Aloe vera leaves against influenza virus infection. METHODS: In vitro antiviral property of aloin was measured by plaque reduction assay in which MDCK cells were infected with oseltamivir-sensitive A(H1N1)pdm09, osel (mais)

Genetic characterisation of influenza A(H1N1)pdm09 viruses circulating in Assam, Northeast India during 2009-2015.

Autor(es): Biswas, Dipankar; Dutta, Mousumi; Sarmah, Kimmi; Yadav, Kaushal; Buragohain, Manika; Sarma, Kishore; Borkakoty, Biswajyoti
Fonte: Indian J Med Microbiol;37(1): 42-49, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31424009
Resumo: Introduction: Influenza A(H1N1)pdm09 virus, since its identification in April 2009, has continued to cause significant outbreaks of respiratory tract infections including pandemics in humans. In the course of its evolution, the virus has acquired many mutations with an ability to cause increased disease severity. A regular molecular surveillance of the virus is essential to mark the evolutionary changes that may cause a shift to the viral behavior. Materials and Methods: Samples of Throat/N (mais)

[Clinical analysis of seven cases of H1N1 influenza-associated encephalopathy in children].

Autor(es): Li, X F; Ai, B; Ye, J W; He, D M; Tan, L M; Chen, M X; Yang, H M; Zeng, F S; Yang, F X; Liu, H S; Xu, Y
Fonte: Zhonghua Er Ke Za Zhi;57(7): 538-542, 2019 Jul 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31269554
Resumo: Objective: To investigate the clinical manifestations, diagnosis, and treatment of H1N1 influenza A-associated encephalopathy (IAE) in children. Methods: The clinical manifestations, laboratory tests, cranial magnetic resonance imaging (MRI), electroencephalography (EEG) examinations and treatments of seven children with H1N1 IAE hospitalized in Guangzhou Women and Children's Medical Center from December 2018 to January 2019 were retrospectively analyzed. Results: Five of the seven children (mais)
Resultados  1-12 de 1.382