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Antiviral Activity of Fritillaria thunbergii Extract against Human Influenza Virus H1N1 (PR8) In Vitro, In Ovo and In Vivo.

Author(s): Kim, Minjee; Nguyen, Dinh-Van; Heo, Yoonki; Park, Ki Hoon; Paik, Hyun-Dong; Kim, Young Bong
Source: J Microbiol Biotechnol;30(2): 172-177, 2020 Feb 28.
MEDLINE - International Database for Medical Literature PMID: 31752057
Abstract: Influenza viruses cause respiratory diseases in humans and animals with high morbidity and mortality rates. Conventional anti-influenza drugs are reported to exert side effects and newly emerging viral strains tend to develop resistance to these commonly used agents. Fritillaria thunbergii (FT) is traditionally used as an expectorant for controlling airway inflammatory disorders. Here, we evaluated the therapeutic effects of FT extracts against influenza virus type A (H1N1) infection in vit (more)

Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264.7 cells.

Author(s): Tian, Jing; Qu, Na; Jiao, Xue; Wang, Xiaonan; Geng, Jin; Griffin, Noreen; Shan, Fengping
Source: Int Immunopharmacol;78: 106032, 2020 Jan.
MEDLINE - International Database for Medical Literature PMID: 31835089
Abstract: MENK, as an immune adjuvant, has potential immune-regulatory activity on innate and adaptive immune cells. The aim of this work was to investigate the antiviral effect of MENK on influenza virus-infected murine macrophage cells (RAW264.7) and its underlying mechanisms. The results showed that MENK markedly inhibited influenza A virus (H1N1) replication in pre- and post-MENK treatment, especially in pre-MENK treatment. The mechanisms exploration revealed that MENK (10 mg/mL) significant (more)

Antiviral activity of amides and carboxamides of quinolizidine alkaloid (-)-cytisine against human influenza virus A (H1N1) and parainfluenza virus type 3.

Author(s): Fedorova, Victoria A; Kadyrova, Renata A; Slita, Alexander V; Muryleva, Anna A; Petrova, Polina R; Kovalskaya, Alena V; Lobov, Alexander N; Zileeva, Zulfiya R; Tsypyshev, Dmiry O; Borisevich, Sophia S; Tsypysheva, Inna P; Vakhitova, Julia V; Zarubaev, Vladimir V
Source: Nat Prod Res;: 1-9, 2019 Dec 02.
MEDLINE - International Database for Medical Literature PMID: 31790286
Abstract: Novel derivatives of quinolizidine alkaloid (-)-cytisine were synthesised. ADME properties, cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09(H1N1)pdm09 virus (IAV) and human parainfluenza virus type 3 (HPIV3) were evaluated. It was shown, that 9-carboxamides of methylcytisine (with phenyl and allyl urea's fragments) are most active compounds against IAV probably due to predicted in silico peculiarity of their interactions with the 4R7B active si (more)

Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan's unique ecosystems against influenza viruses and paramyxoviruses.

Author(s): Berezin, Vladimir; Abdukhakimova, Diyora; Trenozhnikova, Lyudmila; Bogoyavlenskiy, Andrey; Turmagambetova, Aizhan; Issanov, Alpamys; Azizan, Azliyati
Source: Virol J;16(1): 150, 2019 12 02.
MEDLINE - International Database for Medical Literature PMID: 31791359
Abstract: BACKGROUND: Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resistance. A potential solution for this emerging issue is to create new antiviral drugs from available compounds of natural products. It is known that the majority of drugs have been developed using compounds (more)

Influenza viruses that require 10 genomic segments as antiviral therapeutics.

Author(s): Harding, Alfred T; Haas, Griffin D; Chambers, Benjamin S; Heaton, Nicholas S
Source: PLoS Pathog;15(11): e1008098, 2019 11.
MEDLINE - International Database for Medical Literature PMID: 31730644
Abstract: Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting virion incompletely infectious. It is known that the accumulation of these defective particles can limit viral disease by interfering with the spread of fully infectious particles. In order to harness this phenomenon therapeutically, we defined which viral packaging signals were amena (more)

Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.

Author(s): Wei, Fanhua; Jiang, Zhimin; Sun, Honglei; Pu, Juan; Sun, Yipeng; Wang, Mingyang; Tong, Qi; Bi, Yuhai; Ma, Xiaojing; Gao, George Fu; Liu, Jinhua
Source: PLoS Pathog;15(10): e1008062, 2019 10.
MEDLINE - International Database for Medical Literature PMID: 31585000
Abstract: Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infection. Using a PGRN knockdown assay and PGRN-deficient mice model, we demonstrated that influenza virus-inducing PGRN negatively regulated type I IFNs production by inhibiting t (more)

[Antiviral effect of «Kagocel¼ substance in vitro on influenza viruses H1N1, H1N1pdm09 and H3N2.]

Author(s): Fediakina, I T; Konopleva, M V; Proshina, E S; Linnik, E V; Nikitina, N I
Source: Vopr Virusol;64(3): 125-131, 2019.
MEDLINE - International Database for Medical Literature PMID: 31622059
Abstract: INTRODUCTION: Active circulation of pandemic influenza and new variants of influenza H3N2 strains requires monitoring of antiviral efficacy of drugs permitted for influenza therapy in the Russian Federation. PURPOSE: Assessment of antiviral efficacy of «Kagocel¼ substance against influenza viruses H1N1, H1N1pdm09 and H3N2 in vitro. MATERIAL AND METHODS: Cytotoxic effect of «Kagocel¼ substance on MDCK cells had been determined by stained with MTS. Antiviral efficacy of «Kagocel¼ substa (more)

A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic.

Author(s): Venkatesan, Sudhir; Nguyen-Van-Tam, Jonathan S; Siebers, Peer-Olaf
Source: PLoS One;14(10): e0223946, 2019.
MEDLINE - International Database for Medical Literature PMID: 31622404
Abstract: The importance of accounting for social and behavioural processes when studying public health emergencies has been well-recognised. For infectious disease outbreaks in particular, several methods of incorporating individual behaviour have been put forward, but very few are based on established psychological frameworks. In this paper, we develop a decision framework based on the COM-B model of behaviour change to investigate the impact of individual decision-making on public health outcomes. (more)

Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies.

Author(s): Job, E R; Ysenbaert, T; Smet, A; Van Hecke, A; Meuris, L; Kleanthous, H; Saelens, X; Vogel, T U
Source: mBio;10(5)2019 10 22.
MEDLINE - International Database for Medical Literature PMID: 31641082
Abstract: Influenza virus neuraminidase (NA) has been under intense study recently as a vaccine antigen, yet there remain unanswered questions regarding the immune response directed toward NA. Antibodies (Abs) that can inhibit NA activity have been shown to aid in the control of disease caused by influenza virus infection in humans and animal models, yet how and if interactions between the Fc portion of anti-NA Abs and Fcγ receptors (FcγR) contribute to protection has not yet been extensively s (more)

Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus-infected mice.

Author(s): Takahashi, E; Sawabuchi, T; Kimoto, T; Sakai, S; Kido, H
Source: J Dairy Sci;102(11): 9559-9569, 2019 Nov.
MEDLINE - International Database for Medical Literature PMID: 31495632
Abstract: Antiviral neuraminidase inhibitors, such as oseltamivir, zanamivir, and peramivir, are widely used for treatment of influenza virus infection. We reported previously that oseltamivir inhibits the viral growth cycle, ameliorates symptoms, and reduces viral antigen quantities. Suppressed viral antigen production, however, induces a reduction of acquired antiviral humoral immunity, and increases the incidence of re-infection rate in the following year. To achieve effective treatment of influen (more)

Envelope-deforming antiviral peptide derived from influenza virus M2 protein.

Author(s): Jung, Younghun; Kong, Byoungjae; Moon, Seokoh; Yu, Seok-Hyeon; Chung, Jinhyo; Ban, Choongjin; Chung, Woo-Jae; Kim, Sung-Gun; Kweon, Dae-Hyuk
Source: Biochem Biophys Res Commun;517(3): 507-512, 2019 09 24.
MEDLINE - International Database for Medical Literature PMID: 31375212
Abstract: Molecules interfering with lipid bilayer function exhibit strong antiviral activity against a broad range of enveloped viruses, with a lower risk of resistance development than that for viral protein-targeting drugs. Amphipathic peptides are rich sources of such membrane-interacting antivirals. Here, we report that influenza viruses were effectively inactivated by M2 AH, an amphipathic peptide derived from the M2 protein of the influenza virus. Although overall hydrophobicity () of M2 AH (more)

Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.

Author(s): Bavagnoli, Laura; Campanini, Giulia; Forte, Maurizio; Ceccotti, Giorgia; Percivalle, Elena; Bione, Silvia; Lisa, Antonella; Baldanti, Fausto; Maga, Giovanni
Source: Antiviral Res;171: 104593, 2019 11.
MEDLINE - International Database for Medical Literature PMID: 31470040
Abstract: The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppressor of NS1 expression and influenza virus replication. Transcriptomic analysis indicates that hsa-miR-1307-3p also negatively regulates apoptosis and promotes cell proliferation. In addition, we identified a novel mutation in the NS1 gene of A (more)
Results  1-12 de 452