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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 307

Treatment of resistant influenza virus infection in a hospitalized patient with cystic fibrosis with DAS181, a host-directed antiviral.

Autor(es): Silveira, Fernanda P; Abdel-Massih, Rima; Bogdanovich, Tatiana; Pakstis, Diana L; Routh, Rebecca L; Moss, Ronald B
Fonte: Antivir Ther;21(1): 71-4, 2016.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26133231
Resumo: We report a cystic fibrosis patient infected with influenza 2009H1N1 who had persistent viral shedding and clinical deterioration despite prolonged treatment with oseltamivir and zanamivir. The patient was diagnosed with H275Y neuraminidase inhibitor resistant influenza during treatment, thus was treated for 10 days with DAS181, an investigational host-directed inhaled sialidase fusion protein. Viral clearance occurred after 5 days of therapy and the patient became eligible for lung transpl (mais)

Influenza virus surveillance in Argentina during the 2012 season: antigenic characterization, genetic analysis and antiviral susceptibility.

Autor(es): Benedetti, E; Daniels, R S; Pontoriero, A; Russo, M; Avaro, M; Czech, A; Campos, A; Periolo, N; Gregory, V; McCauley, J W; Baumeister, E G
Fonte: Epidemiol Infect;144(4): 751-67, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26345289
Resumo: The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up b (mais)

Antiviral effects of Yinhuapinggan granule against influenza virus infection in the ICR mice model.

Autor(es): Peng, Xue-qian; Zhou, Hui-fen; Zhang, Yu-yan; Yang, Jie-hong; Wan, Hai-tong; He, Yu
Fonte: J Nat Med;70(1): 75-88, 2016 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26439479
Resumo: Yinhuapinggan granule (YHPG), a Chinese medicine granule based on Ma-Huang-Tang (Ephedra Decoction) and the clinical experience of Professor Wan Haitong, is used in traditional Chinese medicine (TCM) for the treatment of colds, influenza, fever, inflammation and cough. This study investigated the antiviral effects of YHPG on the production of inflammatory cytokines in influenza virus (IFV)-infected mice and evaluated the effect of YHPG on the expression of NF-κB p65 and the level of ke (mais)

Influenza virusssurveillance by the instituto aolfo lutz, influenza season 20114: antiviral resistacee

Autor(es): Santos, Katia Corrêa de Oliveira; Silva, Daniela Bernardes Borges da; Benega, Margarete Aparecida; Paulino, Renato de Sousa; E Silva Jr, Elian Reis; Pereira, Dejanira dos Santos; Mussi, Aparecida Duarte Hg; Silva, Valéria Cristina da; V. Gubareva, Larissa; Paiva, Terezinha Maria de
Fonte: Rev. Inst. Med. Trop. Säo Paulo;57(1): 92-92, Jan-Feb/2015.
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 736371

Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

Autor(es): Souza, Thiago Moreno Lopes e; Fintelman-Rodrigues, Natalia; Resende, Paola Cristina; Mesquita, Milene; Gregianini, Tatiana Schaffer; Bozza, Fernando A; Pecego, Ana Carla; Fernandes, Sandra Bianchini; Cury, Ana Luisa Furtado; Riediger, Irina Nastassja; Siqueira, Marilda M
Fonte: Mem. Inst. Oswaldo Cruz;110(1): 101-105, 03/02/2015. tab, graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 741611
Resumo: The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations. We display t (mais)

Influenza virus surveillance by the Insituto Adolfo Lutz, influenza season 2014: antiviral resistance

Autor(es): Santos, K C; Silva, D B; Benega, M A; Paulino, R de S; Silva, E R; Pereira, D dos S; Mussi, A D; Silva, V C; Gubareva, V; Paiva, T M
Fonte: Rev Inst Med Trop São Paulo;57(1): 92-92, 2015.
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 1022107
Resumo: Neuraminidase (NA) inhibitors (NAIs) are the only antivirals that are effective for prophylaxis and the treatment of seasonal influenza A and B infections. There are currently two NAIs approved in most countries: oseltamivir (Tamiflu; F. Hoffmann - La Roche) and zanamivir (Relenza; GlaxoSmithKline plc.). The development of drug resistance is a major drawback for any antiviral therapy, and these specific anti-influenza drugs are not excluded from this rule. Thus, the proper use of NAIs and w (mais)

Influenza A(H1N1)pdm09 resistance and cross-decreased susceptibility to oseltamivir and zanamivir antiviral drugs.

Autor(es): Correia, Vanessa; Santos, Luis A; Gíria, Marta; Almeida-Santos, Maria M; Rebelo-de-Andrade, Helena
Fonte: J Med Virol;87(1): 45-56, 2015 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 25042157
Resumo: Neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are currently the only effective antiviral drugs available worldwide for the management of influenza. The potential development of resistance is continually threatening their use, rationalizing and highlighting the need for a close and sustained evaluation of virus susceptibility. This study aimed to analyze and characterize the phenotypic and genotypic NAIs susceptibility profiles of A(H1N1)pdm09 viruses circulating in Portugal from (mais)

Degree of adherence to recommended antiviral treatment during the pandemic and post-pandemic periods of influenza A(H1N1)pdm09 in 148 intensive care units in Spain.

Autor(es): Canadell, L; Martín-Loeches, I; Díaz, E; Trefler, S; Grau, S; Yebenes, J C; Almirall, J; Olona, M; Sureda, F; Blanquer, J; Rodriguez, A
Fonte: Med Intensiva;39(4): 222-33, 2015 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 25107582
Resumo: OBJECTIVE: To determine the degree of antiviral treatment recommendations adherence and its impact to critical ill patients affected by influenza A(H1N1)pdm09 mortality. DESIGN: Secondary analysis of prospective study. SETTING: Intensive care (UCI). PATIENTS: Patients with influenza A(H1N1)pdm09 in the 2009 pandemic and 2010-11 post-Pandemic periods. VARIABLES: Adherence to recommendations was classified as: Total (AT); partial in doses (PD); partial in time (PT), and non-adherence (NA). Vi (mais)

[The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza ].

Autor(es): Kolobukhina, L V; Burtseva, E I; Shelkanov, M Iu; Al'khovskii, S V; Prilipov, A G; Merkulova, L N; Kisteneva, L B; Vartanian, R V; Kruzhkova, I S; Trushakova, S V; Krasnoslobodtsev, K G; Avdeev, S M; Sutochnikova, O A; Bazarova, M V; Kelly, E I; Ambrosi, O E; Malyshev, n A; L'vov, D K; Chuchalin, A G
Fonte: Ter Arkh;86(10): 52-9, 2014.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 25509893
Resumo: AIM: To characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients. SUBJECTS AND METHODS: The investigators examined 1203 patients (387 children, 509 people older than 16 years of age, 307 pregnant women) admitted to Moscow Clinical Infectious Diseases Hospital One with the clinical signs of acute respiratory viral diseases. Nasal lavage and autop (mais)

Antiviral activity of Basidiomycete mycelia against influenza type A (serotype H1N1) and herpes simplex virus type 2 in cell culture.

Autor(es): Krupodorova, Tetiana; Rybalko, Svetlana; Barshteyn, Victor
Fonte: Virol Sin;29(5): 284-90, 2014 Oct.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 25358999
Resumo: In this study, we investigated the in vitro antiviral activity of the mycelia of higher mushrooms against influenza virus type A (serotype H1N1) and herpes simplex virus type 2 (HSV-2), strain BH. All 10 investigated mushroom species inhibited the reproduction of influenza virus strain A/FM/1/47 (H1N1) in MDCK cells reducing the infectious titer by 2.0-6.0 lg ID50. Four species, Pleurotus ostreatus, Fomes fomentarius, Auriporia aurea, and Trametes versicolor, were also determined to be effe (mais)

Antiviral drug profile of human influenza A & B viruses circulating in India: 2004-2011.

Autor(es): Potdar, V A; Dakhave, M R; Kulkarni, P B; Tikhe, S A; Broor, S; Gunashekaran, P; Chawla-Sarkar, M; Abraham, A; Bishwas, D; Patil, K N; Kadam, A A; Kode, S S; Mishra, A C; Chadha, M S
Fonte: Indian J Med Res;140(2): 244-51, 2014 Aug.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 25297358
Resumo: BACKGROUND & OBJECTIVES: Recent influenza antiviral resistance studies in South East Asia, Europe and the United States reveal adamantane and neuraminidase inhibitor (NAIs) resistance. This study was undertaken to evaluate antiviral resistance in influenza viruses isolated from various parts of India, during 2004 to 2011. METHODS: Influenza viruses were analyzed genetically for known resistance markers by M2 and NA gene sequencing. Influenza A/H1N1 (n=206), A/H3N2 (n=371) viruses for amanta (mais)
Resultados  1-12 de 307