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Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.

Author(s): Ilyushina, Natalia A; Komatsu, Takashi E; Ince, William L; Donaldson, Eric F; Lee, Nicolette; O'Rear, Julian J; Donnelly, Raymond P
Source: Virol J;16(1): 149, 2019 11 29.
MEDLINE - International Database for Medical Literature PMID: 31783761
Abstract: BACKGROUND: Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the influenza hemagglutinin (HA) protein. Numerous HA substitutions have been identified in nonclinical NAI resistance-selection experiments as well as in clinical specimens from NAI treatment or surveillance studies. These mutations are listed in th (more)

Update: Influenza Activity - United States and Worldwide, May 19-September 28, 2019, and Composition of the 2020 Southern Hemisphere Influenza Vaccine.

Author(s): Epperson, Scott; Davis, C Todd; Brammer, Lynnette; Abd Elal, Anwar Isa; Ajayi, Noreen; Barnes, John; Budd, Alicia P; Burns, Erin; Daly, Peter; Dugan, Vivien G; Fry, Alicia M; Jang, Yunho; Johnson, Sara Jo; Kniss, Krista; Kondor, Rebecca; Grohskopf, Lisa A; Gubareva, Larisa; Merced-Morales, Angiezel; Sessions, Wendy; Stevens, James; Wentworth, David E; Xu, Xiyan; Jernigan, Daniel
Source: MMWR Morb Mortal Wkly Rep;68(40): 880-884, 2019 Oct 11.
MEDLINE - International Database for Medical Literature PMID: 31600182
Abstract: During May 19-September 28, 2019,* low levels of influenza activity were reported in the United States, with cocirculation of influenza A and influenza B viruses. In the Southern Hemisphere seasonal influenza viruses circulated widely, with influenza A(H3) predominating in many regions; however, influenza A(H1N1)pdm09 and influenza B viruses were predominant in some countries. In late September, the World Health Organization (WHO) recommended components for the 2020 Southern Hemisphere infl (more)

Recommendations for Prevention and Control of Influenza in Children, 2019-2020.

Source: Pediatrics;144(4)2019 10.
MEDLINE - International Database for Medical Literature PMID: 31477606
Abstract: This statement updates the recommendations of the American Academy of Pediatrics for the routine use of influenza vaccines and antiviral medications in the prevention and treatment of influenza in children during the 2019-2020 season. The American Academy of Pediatrics continues to recommend routine influenza immunization of all children without medical contraindications, starting at 6 months of age. Any licensed, recommended, age-appropriate vaccine available can be administered, without p (more)

Molecular characterization of influenza A(H1N1)pdm09 viruses circulating at various geographical locations in India, 2017.

Author(s): Potdar, Varsha; Vijay, Neetu; Gupta, Nivedita; Arunkumar, G; Borkakoty, Bishwajyoti; Malhotra, Bharti; Rabha, Debajit; Hinge, Dilip; Kaur, Harmanmeet; Chadha, Mandeep
Source: Indian J Med Res;149(6): 783-789, 2019 06.
MEDLINE - International Database for Medical Literature PMID: 31496532
Abstract: Background & objectives: Influenza virological surveillance is an essential tool for the early detection of novel genetic variants of epidemiologic and clinical significance. This study was aimed to genetically characterize A(H1N1)pdm09 virus circulating in 2017 and to compare it with the global data. Methods: The regional/State Viral Research and Diagnostic Laboratories (VRDLs) provided influenza diagnosis for referred clinical samples and shared influenza A(H1N1)pdm09 positives with the I (more)

Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza.

Author(s): Huang, Ching-Tai; Hung, Chen-Yiu; Hseih, Yu-Chia; Chang, Chia-Shiang; Velu, Arul Balaji; He, Yueh-Chia; Huang, Yu-Lin; Chen, Ting-An; Chen, Tse-Ching; Lin, Chun-Yen; Lin, Yung-Chang; Shih, Shin-Ru; Dutta, Avijit
Source: Phytomedicine;64: 152904, 2019 Nov.
MEDLINE - International Database for Medical Literature PMID: 31454654
Abstract: BACKGROUND: Millions of people are infected by the influenza virus worldwide every year. Current selections of anti-influenza agents are limited and their effectiveness and drug resistance are still of concern. PURPOSE: Investigation on in vitro and in vivo effect of aloin from Aloe vera leaves against influenza virus infection. METHODS: In vitro antiviral property of aloin was measured by plaque reduction assay in which MDCK cells were infected with oseltamivir-sensitive A(H1N1)pdm09, osel (more)

Severe cases of seasonal influenza in Russia in 2017-2018.

Author(s): Kolosova, Natalia P; Ilyicheva, Tatyana N; Danilenko, Alexey V; Bulanovich, Julia A; Svyatchenko, Svetlana V; Durymanov, Alexander G; Goncharova, Natalia I; Gudymo, Andrei S; Shvalov, Alexander N; Susloparov, Ivan M; Marchenko, Vasiliy Y; Tregubchak, Tatyana V; Gavrilova, Elena V; Maksyutov, Rinat A; Ryzhikov, Alexander B
Source: PLoS One;14(7): e0220401, 2019.
MEDLINE - International Database for Medical Literature PMID: 31356626
Abstract: The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017. During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza (more)

Update: Influenza Activity in the United States During the 2018-19 Season and Composition of the 2019-20 Influenza Vaccine.

Author(s): Xu, Xiyan; Blanton, Lenee; Elal, Anwar Isa Abd; Alabi, Noreen; Barnes, John; Biggerstaff, Matthew; Brammer, Lynnette; Budd, Alicia P; Burns, Erin; Cummings, Charisse N; Garg, Shikha; Kondor, Rebecca; Gubareva, Larisa; Kniss, Krista; Nyanseor, Sankan; O'Halloran, Alissa; Rolfes, Melissa; Sessions, Wendy; Dugan, Vivien G; Fry, Alicia M; Wentworth, David E; Stevens, James; Jernigan, Daniel
Source: MMWR Morb Mortal Wkly Rep;68(24): 544-551, 2019 Jun 21.
MEDLINE - International Database for Medical Literature PMID: 31220057
Abstract: Influenza activity* in the United States during the 2018-19 season (September 30, 2018-May 18, 2019) was of moderate severity (1). Nationally, influenza-like illness (ILI)† activity began increasing in November, peaked during mid-February, and returned to below baseline in mid-April; the season lasted 21 weeks,§ making it the longest season in 10 years. Illness attributed to influenza A viruses predominated, with very little influenza B activity. Two waves of influenza A were notable duri (more)

Circulation and characterization of seasonal influenza viruses in Cambodia, 2012-2015.

Author(s): Horwood, Paul F; Karlsson, Erik A; Horm, Srey Viseth; Ly, Sovann; Heng, Seng; Chin, Savuth; Darapheak, Chau; Saunders, David; Chanthap, Lon; Rith, Sareth; Y, Phalla; Chea, Kim Lay; Sar, Borann; Parry, Amy; Ieng, Vanra; Tsuyouka, Reiko; Deng, Yi-Mo; Hurt, Aeron C; Barr, Ian G; Komadina, Naomi; Buchy, Philippe; Dussart, Philippe
Source: Influenza Other Respir Viruses;13(5): 465-476, 2019 09.
MEDLINE - International Database for Medical Literature PMID: 31251478
Abstract: BACKGROUND: Influenza virus circulation is monitored through the Cambodian influenza-like illness (ILI) sentinel surveillance system and isolates are characterized by the National Influenza Centre (NIC). Seasonal influenza circulation has previously been characterized by year-round activity and a peak during the rainy season (June-November). OBJECTIVES: We documented the circulation of seasonal influenza in Cambodia for 2012-2015 and investigated genetic, antigenic, and antiviral resistance (more)

Construction and synthesis of tricyclic matrinic derivatives against influenza A virus by privileged structure strategy.

Author(s): Jiang, Jing; Zhao, Xiaoqiang; Niu, Tianyu; Yan, Haiyan; Yinghong, L I; Yuhuan, L I; Song, Danqing; Tang, Sheng; Xing, Jianguo
Source: Pharmazie;74(5): 265-269, 2019 05 01.
MEDLINE - International Database for Medical Literature PMID: 31109395
Abstract: A series of new matrinic derivatives with an 11-adamantyl group were designed, synthesized and evaluated for their anti-influenza A H3N2 activities, based on the privileged structure strategy.SAR analysis indicated that introduction of an 11-adamantyl by ester linker might be helpful for the activity. Among them, compound 7b exhibited promising anti-H3N2 activities with IC50 value of 5.14 µM, slightly better than that of amantadine. Its activity was further confirmed at the protein level. (more)

Antiviral treatment and virological monitoring of oseltamivir-resistant influenza virus A(H1N1)pdm09 in a patient with chronic B lymphocytic leukemia.

Author(s): Salata, Cristiano; Sgarabotto, Dino; Del Vecchio, Claudia; Solimbergo, Erica; Marini, Giulia; Nicolè, Stefano; Franchin, Elisa; Parolin, Cristina; Calistri, Arianna; Palù, Giorgio
Source: J Infect Chemother;25(7): 543-546, 2019 Jul.
MEDLINE - International Database for Medical Literature PMID: 31014561
Abstract: We report the virological monitoring and the antiviral therapy adopted for the treatment of a patient affected by chronic B lymphocytic leukemia, who experienced a severe pneumonia with long-term shedding of influenza virus A(H1N1)pdm09, characterized by an early development of oseltamivir resistance.

Community spread and late season increased incidence of oseltamivir-resistant influenza A(H1N1) viruses in Norway 2016.

Author(s): Bragstad, Karoline; Hungnes, Olav; Litleskare, Irene; Nyrerød, Hans Christian; Dorenberg, Dagny H; Hauge, Siri H
Source: Influenza Other Respir Viruses;13(4): 372-381, 2019 07.
MEDLINE - International Database for Medical Literature PMID: 30834715
Abstract: BACKGROUND: Antiviral resistance in Norwegian influenza viruses is rare. Only one A(H1N1)pdm09 virus from May 2015 had been found resistant to oseltamivir since the introduction of these viruses in 2009. OBJECTIVES: Surveillance of antiviral resistance is part of the Norwegian surveillance system, to rapidly detect the development of antiviral-resistant viruses and spread in the community. We describe the spread of oseltamivir-resistant A(H1N1)pdm09 viruses in Norway in the 2016-17 season, (more)

Baloxavir marboxil: the new influenza drug on the market.

Author(s): O'Hanlon, Ryan; Shaw, Megan L
Source: Curr Opin Virol;35: 14-18, 2019 04.
MEDLINE - International Database for Medical Literature PMID: 30852344
Abstract: For the first time in nearly 20 years there is a new class of antiviral drug for influenza. The latest approved antiviral is baloxavir marboxil (trade name, Xofluza) which targets the endonuclease function of the viral PA polymerase subunit and prevents the transcription of viral mRNA. The most promising aspect of this new drug is its pharmacology which allows for effective treatment of influenza A or B virus infection with just a single dose. A clinical trial showed greater reductions in v (more)
Results  1-12 de 871