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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 923

A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9.

Autor(es): Li, Zhanping; Wan, Zhimin; Li, Tuofan; Xie, Quan; Sun, Haiwei; Chen, Hongjun; Liang, Guangchen; Shao, Hongxia; Qin, Aijian; Ye, Jianqiang
Fonte: Vet Microbiol;228: 39-44, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593378
Resumo: In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus (IAV). These mAbs could react with HA of H7N9, H3N2, and H9N2 with neutralizing activity. A novel linear epitope recognized by these mAbs was identified by peptide-based ELISA, and this epitope was located in TAADYKSTQSAIDQITGKLN at the C terminus of the helix A of H7N9. 3 A11, which is one of (mais)

Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice.

Autor(es): Kuah, Li-Fang; Tang, Lay-Hoon; Sutton, Troy; Lim, Jie-Hui; Sin, Wan-Ling; Lamirande, Elaine; Subbarao, Kanta; Lau, Yuk-Fai
Fonte: J Gen Virol;98(2): 155-165, 2017 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27983474
Resumo: Human infections with A/Jiangxi-Donghu/346/2013 (H10N8) virus have raised concerns about its pandemic potential. In order to develop a vaccine against this virus, the immunogenicity of its haemagglutinin protein was evaluated in mice. Using both whole-virion and recombinant subunit protein vaccines, we showed that two doses of either vaccine elicited neutralizing antibody responses. The protective efficacy of the vaccine-induced responses was assessed using a reverse-genetics-derived H10 re (mais)

A Molecular-Level Account of the Antigenic Hantaviral Surface.

Autor(es): Li, Sai; Rissanen, Ilona; Zeltina, Antra; Hepojoki, Jussi; Raghwani, Jayna; Harlos, Karl; Pybus, Oliver G; Huiskonen, Juha T; Bowden, Thomas A
Fonte: Cell Rep;15(5): 959-967, 2016 05 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 27117403
Resumo: Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula han (mais)

Mapping Antigenic Epitopes on the Human Bocavirus Capsid.

Autor(es): Kailasan, Shweta; Garrison, Jamie; Ilyas, Maria; Chipman, Paul; McKenna, Robert; Kantola, Kalle; Söderlund-Venermo, Maria; Kucinskaite-Kodze, Indre; Zvirbliene, Aurelija; Agbandje-McKenna, Mavis
Fonte: J Virol;90(9): 4670-4680, 2016 May.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26912619
Resumo: UNLABELLED: Human bocaviruses (HBoV1 to -4) are emerging pathogens associated with pneumonia and/or diarrhea in young children. Currently, there is no treatment or vaccination, so there is a need to study these pathogens to understand their disease mechanisms on a molecular and structural level for the development of control strategies. Here, we report the structures of six HBoV monoclonal antibody (MAb) fragment complexes, HBoV1-15C6, HBoV2-15C6, HBoV4-15C6, HBoV1-4C2, HBoV1-9G12, and HBoV (mais)

Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination.

Autor(es): Luo, Zhenwu; Ma, Lei; Zhang, Lumin; Martin, Lisa; Wan, Zhuang; Warth, Stephanie; Kilby, Andrew; Gao, Yong; Bhargava, Pallavi; Li, Zhen; Wu, Hao; Meissner, Eric G; Li, Zihai; Kilby, J Michael; Liao, Guoyang; Jiang, Wei
Fonte: Vaccine;34(16): 1945-55, 2016 Apr 07.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26721328
Resumo: BACKGROUND: There is increasing recognition of the role of B cell dysfunction in HIV pathogenesis, but little is known about how these perturbations may influence responses to vaccinations. METHODS: Healthy controls (n=16) and antiretroviral therapy (ART)-treated aviremic HIV-infected subjects (n=26) receiving standard-of-care annual influenza vaccinations were enrolled in the present study. Total bacterial 16S rDNA levels were assessed by quantitative polymerase chain reactions in plasma. (mais)

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Autor(es): Sobolev, Olga; Binda, Elisa; O'Farrell, Sean; Lorenc, Anna; Pradines, Joel; Huang, Yongqing; Duffner, Jay; Schulz, Reiner; Cason, John; Zambon, Maria; Malim, Michael H; Peakman, Mark; Cope, Andrew; Capila, Ishan; Kaundinya, Ganesh V; Hayday, Adrian C
Fonte: Nat Immunol;17(2): 204-13, 2016 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26726811
Resumo: Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than ∼35 years. Wide-ran (mais)

Concurrent epidemics of influenza A/H3N2 and A/H1N1pdm in Southern China: A serial cross-sectional study.

Autor(es): Wu, Chunli; Wang, Maggie Haitian; Lu, Xing; Chong, Ka Chun; He, Jason; Yau, Chun-Yip; Hui, Mark; Cheng, Xiaowen; Yang, Li; Zee, Benny Chung-Ying; Zhang, Renli; He, Ming-Liang
Fonte: J Infect;72(3): 369-76, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26747013
Resumo: OBJECTIVES: This study aimed to elucidate the antibody response pattern of multiple influenza subtypes through a 4-year serological study of a general population in Shenzhen, Southern China. METHODS: A serial cross-sectional serological survey was conducted at eight time points between 2009 and 2012. A total number of 5876 subjects were recruited from all age groups. The influenza subtypes tested were A/H1N1, A/H3N2, B/Yamagata, B/Victoria, and A/H1N1pdm. Genetic sequencing and phylogenetic (mais)

Evaluation of Screening Assays for the Detection of Influenza A Virus Serum Antibodies in Swine.

Autor(es): Goodell, C K; Prickett, J; Kittawornrat, A; Johnson, J; Zhang, J; Wang, C; Zimmerman, J J
Fonte: Transbound Emerg Dis;63(1): 24-35, 2016 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 24571447
Resumo: Increased surveillance of influenza A virus (IAV) infections in human and swine populations is mandated by public health and animal health concerns. Antibody assays have proven useful in previous surveillance programmes because antibodies provide a record of prior exposure and the technology is inexpensive. The objective of this research was to compare the performance of influenza serum antibody assays using samples collected from pigs (vaccinated or unvaccinated) inoculated with either A/S (mais)

Herd immunity and fatal cases of influenza among the population exposed to poultry and wild birds in Russian Asia in 2013-2014.

Autor(es): Ilyicheva, Tatyana; Abdurashitov, Murat; Durymanov, Alexander; Susloparov, Ivan; Goncharova, Natalya; Kolosova, Natalya; Mikheev, Valery; Ryzhikov, Alexander
Fonte: J Med Virol;88(1): 35-44, 2016 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26105790
Resumo: In total 1,525 blood serum samples were collected in October, 2013 in Russian Asia from people who reside in territories that are at high risk for emergence of influenza viruses with pandemic potential. Presence of antibodies to influenza viruses in the sera was tested in hemagglutination inhibition test. None of the samples produced positive results with the antigens A/H5 and A/H7. Twelve strains of influenza A(H1N1pdm09) virus were isolated from people who died presumably from influenza d (mais)

Long-term seroprotective response of trivalent seasonal influenza vaccine in HIV-infected children, regardless of immunogenicity before immunisation.

Autor(es): Moolasart, Visal; Manosuthi, Weerawat; Ausavapipit, Jarurnsook; Chottanapund, Suthat; Likanonsakul, Sirirat; Uttayamakul, Sumonmal; Srisopha, Somkid; Lerdsamran, Hatairat; Puthavathana, Pilaipan
Fonte: Int J STD AIDS;27(9): 761-8, 2016 08.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26138900
Resumo: Influenza vaccination can reduce disease in HIV-infected children. The durability of the antibody response after trivalent influenza vaccine is important for management. The aim of this prospective study was to assess the durability of seroprotection for trivalent influenza vaccine strains and the factors effecting seroprotective response regardless of immunogenicity before trivalent influenza vaccine at one and six months after immunisation. Hemagglutination inhibition assay was done at on (mais)

Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses.

Autor(es): Wang, Wei; Alvarado-Facundo, Esmeralda; Chen, Qiong; Anderson, Christine M; Scott, Dorothy; Vassell, Russell; Weiss, Carol D
Fonte: J Infect Dis;213(3): 403-6, 2016 Feb 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26243315
Resumo: We examined serum samples from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-neutralizing antibodies to potential pandemic strains. Using pseudoviruses bearing various hemagglutinins (HA-pseudoviruses), we found serum neutralization titers (≥160) in 100% against A/Japan/305/1957 (H2N2), 53% against A/Hong Kong/1073/99 (H9N2), 56% against the H3N2 variant A/Indiana/08/11 (H3N2v), 11% against A/Hong Kong/G9/97 (H9N2), and 36% A/chicken/H (mais)

Immunogenicity and sustainability of the immune response in Brazilian HIV-1-infected individuals vaccinated with inactivated triple influenza vaccine.

Autor(es): Souza, Thiago Moreno L; Santini-Oliveira, Marilia; Martorelli, Andressa; Luz, Paula M; Vasconcellos, Mauricio T L; Giacoia-Gripp, Carmem B W; Morgado, Mariza; Nunes, Estevão P; Lemos, Alberto S; Ferreira, Ana C G; Moreira, Ronaldo I; Veloso, Valdiléa G; Siqueira, Marilda; Grinsztejn, Beatriz; Camacho, Luiz A B
Fonte: J Med Virol;88(3): 426-36, 2016 Mar.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 26267817
Resumo: HIV-infected individuals have a higher risk of serious illnesses following infection by infection with influenza. Although anti-influenza vaccination is recommended, immunosuppression may limit their response to active immunization. We followed-up a cohort of HIV-infected individuals vaccinated against influenza to assess the immunogenicity and sustainability of the immune response to vaccination. Individuals were vaccinated 2011 with inactivated triple influenza vaccine (TIV), and they had (mais)
Resultados  1-12 de 923