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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 1.259

Biotinylated Single-Domain Antibody-Based Blocking ELISA for Detection of Antibodies Against Swine Influenza Virus.

Autor(es): Du, Taofeng; Zhu, Guang; Wu, Xiaoping; Fang, Junyang; Zhou, En-Min
Fonte: Int J Nanomedicine;14: 9337-9349, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31819435
Resumo: Background: Enzyme-linked immunosorbent assay (ELISA) is a common method for diagnosing swine influenza. However, the production of classical antibodies is both costly and time-consuming. As a promising alternative diagnostic tool, single-domain antibodies (sdAbs) offer the advantages of simpler and faster generation, good stability and solubility, and high affinity and specificity. Methods: Phage display technology was used to isolate sdAbs against the SIV-NP protein from a camel VHH libra (mais)

Aptamer-Antibody Complementation On Multiwalled Carbon Nanotube-Gold Transduced Dielectrode Surfaces To Detect Pandemic Swine Influenza Virus.

Autor(es): Wang, Fang; Gopinath, Subash Cb; Lakshmipriya, Thangavel
Fonte: Int J Nanomedicine;14: 8469-8481, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31695375
Resumo: Background: A pandemic influenza viral strain, influenza A/California/07/2009 (pdmH1N1), has been considered to be a potential issue that needs to be controlled to avoid the seasonal emergence of mutated strains. Materials and methods: In this study, aptamer-antibody complementation was implemented on a multiwalled carbon nanotube-gold conjugated sensing surface with a dielectrode to detect pandemic pdmH1N1. Preliminary biomolecular and dielectrode surface analyses were performed by molecul (mais)

Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination.

Autor(es): Ryt-Hansen, Pia; Pedersen, Anders Gorm; Larsen, Inge; Krog, Jesper Schak; Kristensen, Charlotte Sonne; Larsen, Lars Erik
Fonte: PLoS One;14(11): e0224854, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31725751
Resumo: Influenza A virus (IAV) is a highly contagious pathogen in pigs. Swine IAV (swIAV) infection causes respiratory disease and is thereby a challenge for animal health, animal welfare and the production economy. In Europe, the most widespread strategy for controlling swIAV is implementation of sow vaccination programs, to secure delivery of protective maternally derived antibodies (MDAs) to the newborn piglets. In this study we report a unique case, where a persistently swIAV (A/sw/Denmark/P5U (mais)

Delivery of a thermo-enzymatically treated influenza vaccine using pulmonary surfactant in pigs.

Autor(es): Vinson, Heather; Singh, Gagandeep; Pillatzki, Angela; Webb, Brett; Nelson, Eric; Ramamoorthy, Sheela
Fonte: Vet Microbiol;239: 108492, 2019 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31767065
Resumo: Swine influenza A virus (IAV-S) infections are a major cause of economic losses for the swine industry. The vast genetic and antigenic diversity often results in mismatch between the vaccine and field strains, necessitating frequent updates of vaccines. Inactivated IAV-S vaccines are of questionable efficacy. Intra-nasally administered live vaccines are more effective but are associated with safety concerns. The objective of this study was to develop a first-generation vaccine which combine (mais)

Serological survey of influenza A virus infection in Japanese wild boars (Sus scrofa leucomystax).

Autor(es): Fujimoto, Yoshikazu; Inoue, Hideya; Ozawa, Makoto; Matsuu, Aya
Fonte: Microbiol Immunol;63(12): 517-522, 2019 Dec.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31595535
Resumo: We conducted a serological survey to detect antibodies against influenza A virus (IAV) in Japanese wild boars in Kagoshima prefecture, Japan, between 2014 and 2017. Seroprevalence against a pandemic-like swine H1N1 (H1N1pdm) virus was identified in 27.1% of specimens, and 1.7% were positive for both swine H1N2 and H3N2 viruses, indicating that wild boars could play an important role in the dynamics of H1N1pdm viral dispersion in the wild. The high frequency of positive results for sera agai (mais)

Serological Array-in-Well Multiplex Assay Reveals a High Rate of Respiratory Virus Infections and Reinfections in Young Children.

Autor(es): Kazakova, Anna; Kakkola, Laura; Päkkilä, Henna; Teros-Jaakkola, Tamara; Soukka, Tero; Peltola, Ville; Waris, Matti; Julkunen, Ilkka
Fonte: mSphere;4(5)2019 09 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31511367
Resumo: Serological assays are used to diagnose and characterize host immune responses against microbial pathogens. Microarray technologies facilitate high-throughput immunoassays of antibody detection against multiple pathogens simultaneously. To improve survey of influenza A virus (IAV), influenza B virus (IBV), respiratory syncytial virus (RSV), and adenovirus (AdV) antibody levels, we developed a microarray consisting of IAV H1N1, IAV H1N1pdm09 (vaccine), IAV H3N2, IBV Victoria, IBV Yamagata, R (mais)

Detection of pandemic influenza A/H1N1/pdm09 virus among pigs but not in humans in slaughterhouses in Kenya, 2013-2014.

Autor(es): Osoro, Eric Mogaka; Lidechi, Shirley; Nyaundi, Jeremiah; Marwanga, Doris; Mwatondo, Athman; Muturi, Mathew; Ng'ang'a, Zipporah; Njenga, Kariuki
Fonte: BMC Res Notes;12(1): 628, 2019 Sep 24.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31551085
Resumo: OBJECTIVE: We conducted four cross-sectional studies over 1 year among humans and pigs in three slaughterhouses in Central and Western Kenya (> 350 km apart) to determine infection and exposure to influenza A viruses. Nasopharyngeal (NP) and oropharyngeal (OP) swabs were collected from participants who reported acute respiratory illness (ARI) defined as fever, cough or running nose. Nasal swabs and blood samples were collected from pigs. Human NP/OP and pig nasal swabs were tested for inf (mais)

Assessment of population susceptibility to upcoming seasonal influenza epidemic strain using interepidemic emerging influenza virus strains.

Autor(es): Chen, Lin-Lei; Wu, Wai-Lan; Chan, Wan-Mui; Fong, Carol H Y; Ng, Anthony C K; Ip, Jonathan D; Lu, Lu; Dissanayake, Thrimendra K; Ding, Xixia; Cai, Jian-Piao; Zhang, Anna J X; Tam, Sidney; Hung, Ivan F N; Chan, Kwok-Hung; Yuen, Kwok-Yung; To, Kelvin K W
Fonte: Epidemiol Infect;147: e279, 2019 09 26.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31556360
Resumo: Seasonal influenza virus epidemics have a major impact on healthcare systems. Data on population susceptibility to emerging influenza virus strains during the interepidemic period can guide planning for resource allocation of an upcoming influenza season. This study sought to assess the population susceptibility to representative emerging influenza virus strains collected during the interepidemic period. The microneutralisation antibody titers (MN titers) of a human serum panel against repr (mais)

Computationally optimized broadly reactive vaccine based upon swine H1N1 influenza hemagglutinin sequences protects against both swine and human isolated viruses.

Autor(es): Skarlupka, Amanda L; Owino, Simon O; Suzuki-Williams, Lui P; Crevar, Corey J; Carter, Donald M; Ross, Ted M
Fonte: Hum Vaccin Immunother;15(9): 2013-2029, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31448974
Resumo: Swine H1 influenza viruses were stable within pigs for nearly 70 years until in 1998 when a classical swine virus reassorted with avian and human influenza viruses to generate the novel triple reassortant H1N1 strain that eventually led to the 2009 influenza pandemic. Previously, our group demonstrated broad protection against a panel of human H1N1 viruses using HA antigens derived by the COBRA methodology. In this report, the effectiveness of COBRA HA antigens (SW1, SW2, SW3 and SW4), whic (mais)

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin.

Autor(es): Lee, Juhye M; Eguia, Rachel; Zost, Seth J; Choudhary, Saket; Wilson, Patrick C; Bedford, Trevor; Stevens-Ayers, Terry; Boeckh, Michael; Hurt, Aeron C; Lakdawala, Seema S; Hensley, Scott E; Bloom, Jesse D
Fonte: Elife;82019 08 27.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31452511
Resumo: A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza's major surface protein affect viral neutralization by polyclonal human sera. The serum of some individuals is so focused that it selects single mutations that reduce viral neutralization by over an order of magnitude. However, different viral mutations escape the sera of different individuals. This (mais)

Seroprevalence of influenza A virus in pigs and low risk of acute respiratory illness among pig workers in Kenya.

Autor(es): Osoro, Eric Mogaka; Lidechi, Shirley; Marwanga, Doris; Nyaundi, Jeremiah; Mwatondo, Athman; Muturi, Mathew; Ng'ang'a, Zipporah; Njenga, Kariuki
Fonte: Environ Health Prev Med;24(1): 53, 2019 Aug 17.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31421676
Resumo: BACKGROUND: Influenza A viruses pose a significant risk to human health because of their wide host range and ability to reassort into novel viruses that can cause serious disease and pandemics. Since transmission of these viruses between humans and pigs can be associated with occupational and environmental exposures, we investigated the association between occupational exposure to pigs, occurrence of acute respiratory illness (ARI), and influenza A virus infection. METHODS: The study was co (mais)

Characterising antibody kinetics from multiple influenza infection and vaccination events in ferrets.

Autor(es): Hay, James A; Laurie, Karen; White, Michael; Riley, Steven
Fonte: PLoS Comput Biol;15(8): e1007294, 2019 08.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31425503
Resumo: The strength and breadth of an individual's antibody repertoire is an important predictor of their response to influenza infection or vaccination. Although progress has been made in understanding qualitatively how repeated exposures shape the antibody mediated immune response, quantitative understanding remains limited. We developed a set of mathematical models describing short-term antibody kinetics following influenza infection or vaccination and fit them to haemagglutination inhibition ( (mais)
Resultados  1-12 de 1.259