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Resultados  1-12 de 3.188
1.

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Autor(es): Ivan, Fransiskus X; Zhou, Xinrui; Lau, Suk Hiang; Rashid, Shamima; Teo, Jasmine S M; Lee, Hong Kai; Koay, Evelyn S; Chan, Kwai Peng; Leo, Yee Sin; Chen, Mark I C; Kwoh, Chee Keong; Chow, Vincent T
Fonte: Int J Infect Dis;90: 84-96, 2020 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31669593
Resumo: BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. METHODS: The complete genomes of influenza A/H1N1, A/H3N2 and B viruses that caused mild infections among outpatients and severe infections among inpatients in Singapore during 2012-2015 were sequenced and characterized. Using various bioinfo (mais)
2.

Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults.

Autor(es): LeBlanc, J J; ElSherif, M; Mulpuru, S; Warhuus, M; Ambrose, A; Andrew, M; Boivin, G; Bowie, W; Chit, A; Dos Santos, G; Green, K; Halperin, S A; Hatchette, T F; Ibarguchi, B; Johnstone, J; Katz, K; Langley, J M; Lagacé-Wiens, P; Loeb, M; Lund, A; MacKinnon-Cameron, D; McCarthy, A; McElhaney, J E; McGeer, A; Poirier, A; Powis, J; Richardson, D; Semret, M; Shinde, V; Smyth, D; Trottier, S; Valiquette, L; Webster, D; Ye, L; McNeil, S A
Fonte: J Med Microbiol;69(2): 256-264, 2020 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31264957
Resumo: Background. The Serious Outcomes Surveillance Network of the Canadian Immunization Research Network (CIRN SOS) has been performing active influenza surveillance since 2009 (ClinicalTrials.gov identifier: NCT01517191). Influenza A and B viruses are identified and characterized using real-time reverse-transcriptase polymerase chain reaction (RT-PCR), and multiplex testing has been performed on a subset of patients to identify other respiratory virus aetiologies. Since both methods can identif (mais)
3.

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.

Autor(es): Bogdanow, Boris; Wang, Xi; Eichelbaum, Katrin; Sadewasser, Anne; Husic, Immanuel; Paki, Katharina; Budt, Matthias; Hergeselle, Martha; Vetter, Barbara; Hou, Jingyi; Chen, Wei; Wiebusch, Lüder; Meyer, Irmtraud M; Wolff, Thorsten; Selbach, Matthias
Fonte: Nat Commun;10(1): 5518, 2019 12 04.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31797923
Resumo: Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. Here we combine metabolic pulse labeling and quantitative proteomics to monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain and observe striking differences in viral protein synthesis. Most importantly, the matrix protein M1 is ineffic (mais)
4.

Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza.

Autor(es): Mawatari, Momoko; Saito, Reiko; Hibino, Akinobu; Kondo, Hiroki; Yagami, Ren; Odagiri, Takashi; Tanabe, Ikumi; Shobugawa, Yugo
Fonte: PLoS One;14(11): e0224683, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31697721
Resumo: BACKGROUND: Neuraminidase inhibitors (NAIs) effectively treat influenza. The clinical effectiveness of four NAIs (oseltamivir, zanamivir, laninamivir, and peramivir) was evaluated against influenza A/H1N1pdm09, A/H3N2, and B viruses. Additionally, fever duration in patients infected with oseltamivir-resistant influenza A/H1N1pdm09 with the H275Y mutation was evaluated. METHODS: Patients aged <20 years who visited outpatient clinics in Japan with influenza-like illnesses were enrolled during (mais)
5.

Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination.

Autor(es): Ryt-Hansen, Pia; Pedersen, Anders Gorm; Larsen, Inge; Krog, Jesper Schak; Kristensen, Charlotte Sonne; Larsen, Lars Erik
Fonte: PLoS One;14(11): e0224854, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31725751
Resumo: Influenza A virus (IAV) is a highly contagious pathogen in pigs. Swine IAV (swIAV) infection causes respiratory disease and is thereby a challenge for animal health, animal welfare and the production economy. In Europe, the most widespread strategy for controlling swIAV is implementation of sow vaccination programs, to secure delivery of protective maternally derived antibodies (MDAs) to the newborn piglets. In this study we report a unique case, where a persistently swIAV (A/sw/Denmark/P5U (mais)
6.

Influenza A(H1N1)pdm09 Virus Infection in a Captive Giant Panda, Hong Kong.

Autor(es): Martelli, Paolo; Teng, Jade L L; Lee, Foo-Khong; Yeong, Kai-Yan; Fong, Jordan Y H; Hui, Suk-Wai; Chan, Kwok-Hung; Lau, Susanna K P; Woo, Patrick C Y
Fonte: Emerg Infect Dis;25(12): 2303-2306, 2019 12.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31742520
Resumo: We report influenza A(H1N1)pdm09 virus infection in a captive giant panda in Hong Kong. The viral load peaked on day 1 and became undetectable on day 5, and an antibody response developed. Genome analysis showed 99.3%-99.9% nucleotide identity between the virus and influenza A(H1N1)pdm09 virus circulating in Hong Kong.
7.

Effect of Forsythiaside A on the RLRs Signaling Pathway in the Lungs of Mice Infected with the Influenza A Virus FM1 Strain.

Autor(es): Zheng, Xiao; Fu, Yingjie; Shi, Shan-Shan; Wu, Sha; Yan, Yuqi; Xu, Liuyue; Wang, Yiwei; Jiang, Zhenyou
Fonte: Molecules;24(23)2019 Nov 20.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31757053
Resumo: Forsythiaside A, a phenylethanoid glycoside monomer extracted from Forsythia suspensa, shows anti-inflammatory, anti-infective, anti-oxidative, and antiviral pharmacological effects. The precise mechanism underlying the antiviral action of forsythiaside A is not completely clear. Therefore, in this study, we aimed to determine whether the anti-influenza action of forsythiaside A occurs via the retinoic acid-inducible gene-I-like receptors (RLRs) signaling pathway in the lung immune cells. F (mais)
8.

IRE1 Signaling As a Putative Therapeutic Target in Influenza Virus-induced Pneumonia.

Autor(es): Schmoldt, Carole; Vazquez-Armendariz, Ana Ivonne; Shalashova, Irina; Selvakumar, Balachandar; Bremer, Corinna M; Peteranderl, Christin; Wasnick, Roxana; Witte, Biruta; Gattenlöhner, Stefan; Fink, Ludger; Vadász, István; Morty, Rory E; Pleschka, Stephan; Seeger, Werner; Günther, Andreas; Herold, Susanne
Fonte: Am J Respir Cell Mol Biol;61(4): 537-540, 2019 10.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31573336
9.

Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus.

Autor(es): Chastagner, Amélie; Bonin, Emilie; Fablet, Christelle; Quéguiner, Stéphane; Hirchaud, Edouard; Lucas, Pierrick; Gorin, Stéphane; Barbier, Nicolas; Béven, Véronique; Garin, Emmanuel; Blanchard, Yannick; Rose, Nicolas; Hervé, Séverine; Simon, Gaëlle
Fonte: Vet Res;50(1): 77, 2019 Oct 07.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31590684
Resumo: This report describes the detection of a triple reassortant swine influenza A virus of H1avN2 subtype. It evolved from an avian-like swine H1avN1 that first acquired the N2 segment from a seasonal H3N2, then the M segment from a 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. This study illustrates how recurrent influenza infections increase the co-infection risk and facilitate evolutionary jumps by successive gene exchanges. It recalls the importance of (mais)
10.

Update: Influenza Activity - United States and Worldwide, May 19-September 28, 2019, and Composition of the 2020 Southern Hemisphere Influenza Vaccine.

Autor(es): Epperson, Scott; Davis, C Todd; Brammer, Lynnette; Abd Elal, Anwar Isa; Ajayi, Noreen; Barnes, John; Budd, Alicia P; Burns, Erin; Daly, Peter; Dugan, Vivien G; Fry, Alicia M; Jang, Yunho; Johnson, Sara Jo; Kniss, Krista; Kondor, Rebecca; Grohskopf, Lisa A; Gubareva, Larisa; Merced-Morales, Angiezel; Sessions, Wendy; Stevens, James; Wentworth, David E; Xu, Xiyan; Jernigan, Daniel
Fonte: MMWR Morb Mortal Wkly Rep;68(40): 880-884, 2019 Oct 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31600182
Resumo: During May 19-September 28, 2019,* low levels of influenza activity were reported in the United States, with cocirculation of influenza A and influenza B viruses. In the Southern Hemisphere seasonal influenza viruses circulated widely, with influenza A(H3) predominating in many regions; however, influenza A(H1N1)pdm09 and influenza B viruses were predominant in some countries. In late September, the World Health Organization (WHO) recommended components for the 2020 Southern Hemisphere infl (mais)
11.

Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia.

Autor(es): Sobolev, Ivan; Kurskaya, Olga; Leonov, Sergey; Kabilov, Marsel; Alikina, Tatyana; Alekseev, Alexander; Yushkov, Yuriy; Saito, Takehiko; Uchida, Yuko; Mine, Junki; Shestopalov, Alexander; Sharshov, Kirill
Fonte: Emerg Microbes Infect;8(1): 1456-1464, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31603050
Resumo: Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. There was a 10% identity difference between the HA and NA nucleotide sequences of isolated strains and the most phylogenetically related sequences (human influenza viruses of 1980s (mais)
12.

Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets.

Autor(es): Stauft, Charles B; Yang, Chen; Coleman, J Robert; Boltz, David; Chin, Chiahsuan; Kushnir, Anna; Mueller, Steffen
Fonte: PLoS One;14(10): e0223784, 2019.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31609986
Resumo: Currently, influenza vaccine manufacturers need to produce 1-5 x 107 PFU of each vaccine strain to fill one dose of the current live-attenuated-influenza-vaccine (LAIV). To make a single dose of inactivated vaccine (15 ug of each hemagglutinin), the equivalent of 1010 PFU of each vaccine strains need to be grown. This high dose requirement is a major drawback for manufacturing as well as rapidly sourcing sufficient doses during a pandemic. Using our computer-aided vaccine platform Synthetic (mais)
Resultados  1-12 de 3.188