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Results  1-12 de 3.191

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Author(s): Ivan, Fransiskus X; Zhou, Xinrui; Lau, Suk Hiang; Rashid, Shamima; Teo, Jasmine S M; Lee, Hong Kai; Koay, Evelyn S; Chan, Kwai Peng; Leo, Yee Sin; Chen, Mark I C; Kwoh, Chee Keong; Chow, Vincent T
Source: Int J Infect Dis;90: 84-96, 2020 Jan.
MEDLINE - International Database for Medical Literature PMID: 31669593
Abstract: BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. METHODS: The complete genomes of influenza A/H1N1, A/H3N2 and B viruses that caused mild infections among outpatients and severe infections among inpatients in Singapore during 2012-2015 were sequenced and characterized. Using various bioinfo (more)

Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults.

Author(s): LeBlanc, J J; ElSherif, M; Mulpuru, S; Warhuus, M; Ambrose, A; Andrew, M; Boivin, G; Bowie, W; Chit, A; Dos Santos, G; Green, K; Halperin, S A; Hatchette, T F; Ibarguchi, B; Johnstone, J; Katz, K; Langley, J M; Lagacé-Wiens, P; Loeb, M; Lund, A; MacKinnon-Cameron, D; McCarthy, A; McElhaney, J E; McGeer, A; Poirier, A; Powis, J; Richardson, D; Semret, M; Shinde, V; Smyth, D; Trottier, S; Valiquette, L; Webster, D; Ye, L; McNeil, S A
Source: J Med Microbiol;69(2): 256-264, 2020 Feb.
MEDLINE - International Database for Medical Literature PMID: 31264957
Abstract: Background. The Serious Outcomes Surveillance Network of the Canadian Immunization Research Network (CIRN SOS) has been performing active influenza surveillance since 2009 ( identifier: NCT01517191). Influenza A and B viruses are identified and characterized using real-time reverse-transcriptase polymerase chain reaction (RT-PCR), and multiplex testing has been performed on a subset of patients to identify other respiratory virus aetiologies. Since both methods can identif (more)

Association of TLR3 single nucleotide polymorphisms with susceptibility to HTLV-1 infection in Iranian asymptomatic blood donors

Author(s): Habibabadi, Hossein Mehrabi; Parsania, Masoud; Pourfathollah, Ali Akbar; Haghighat, Setareh; Sharifi, Zohreh
Source: Rev. Soc. Bras. Med. Trop;53: e20200026, 2020. tab
LILACS - Latin American and Caribbean Health Sciences ID: 1136800
Abstract: Abstract INTRODUCTION: The human T-lymphotropic virus type 1 (HTLV-1) has a single-stranded RNA genome and expresses specific proteins that have oncogenic potential. Approximately 15 to 20 million people worldwide have been infected by this virus. Changes in protein or gene expression are the effects of single nucleotide polymorphisms (SNPs) within the Toll-like receptor 3 (TLR3) gene. The function and efficacy of signal transduction also lead to modified immune responses. The present stud (more)

The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant.

Author(s): Bogdanow, Boris; Wang, Xi; Eichelbaum, Katrin; Sadewasser, Anne; Husic, Immanuel; Paki, Katharina; Budt, Matthias; Hergeselle, Martha; Vetter, Barbara; Hou, Jingyi; Chen, Wei; Wiebusch, Lüder; Meyer, Irmtraud M; Wolff, Thorsten; Selbach, Matthias
Source: Nat Commun;10(1): 5518, 2019 12 04.
MEDLINE - International Database for Medical Literature PMID: 31797923
Abstract: Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. Here we combine metabolic pulse labeling and quantitative proteomics to monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain and observe striking differences in viral protein synthesis. Most importantly, the matrix protein M1 is ineffic (more)

Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza.

Author(s): Mawatari, Momoko; Saito, Reiko; Hibino, Akinobu; Kondo, Hiroki; Yagami, Ren; Odagiri, Takashi; Tanabe, Ikumi; Shobugawa, Yugo
Source: PLoS One;14(11): e0224683, 2019.
MEDLINE - International Database for Medical Literature PMID: 31697721
Abstract: BACKGROUND: Neuraminidase inhibitors (NAIs) effectively treat influenza. The clinical effectiveness of four NAIs (oseltamivir, zanamivir, laninamivir, and peramivir) was evaluated against influenza A/H1N1pdm09, A/H3N2, and B viruses. Additionally, fever duration in patients infected with oseltamivir-resistant influenza A/H1N1pdm09 with the H275Y mutation was evaluated. METHODS: Patients aged <20 years who visited outpatient clinics in Japan with influenza-like illnesses were enrolled during (more)

Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination.

Author(s): Ryt-Hansen, Pia; Pedersen, Anders Gorm; Larsen, Inge; Krog, Jesper Schak; Kristensen, Charlotte Sonne; Larsen, Lars Erik
Source: PLoS One;14(11): e0224854, 2019.
MEDLINE - International Database for Medical Literature PMID: 31725751
Abstract: Influenza A virus (IAV) is a highly contagious pathogen in pigs. Swine IAV (swIAV) infection causes respiratory disease and is thereby a challenge for animal health, animal welfare and the production economy. In Europe, the most widespread strategy for controlling swIAV is implementation of sow vaccination programs, to secure delivery of protective maternally derived antibodies (MDAs) to the newborn piglets. In this study we report a unique case, where a persistently swIAV (A/sw/Denmark/P5U (more)

Influenza A(H1N1)pdm09 Virus Infection in a Captive Giant Panda, Hong Kong.

Author(s): Martelli, Paolo; Teng, Jade L L; Lee, Foo-Khong; Yeong, Kai-Yan; Fong, Jordan Y H; Hui, Suk-Wai; Chan, Kwok-Hung; Lau, Susanna K P; Woo, Patrick C Y
Source: Emerg Infect Dis;25(12): 2303-2306, 2019 12.
MEDLINE - International Database for Medical Literature PMID: 31742520
Abstract: We report influenza A(H1N1)pdm09 virus infection in a captive giant panda in Hong Kong. The viral load peaked on day 1 and became undetectable on day 5, and an antibody response developed. Genome analysis showed 99.3%-99.9% nucleotide identity between the virus and influenza A(H1N1)pdm09 virus circulating in Hong Kong.

Effect of Forsythiaside A on the RLRs Signaling Pathway in the Lungs of Mice Infected with the Influenza A Virus FM1 Strain.

Author(s): Zheng, Xiao; Fu, Yingjie; Shi, Shan-Shan; Wu, Sha; Yan, Yuqi; Xu, Liuyue; Wang, Yiwei; Jiang, Zhenyou
Source: Molecules;24(23)2019 Nov 20.
MEDLINE - International Database for Medical Literature PMID: 31757053
Abstract: Forsythiaside A, a phenylethanoid glycoside monomer extracted from Forsythia suspensa, shows anti-inflammatory, anti-infective, anti-oxidative, and antiviral pharmacological effects. The precise mechanism underlying the antiviral action of forsythiaside A is not completely clear. Therefore, in this study, we aimed to determine whether the anti-influenza action of forsythiaside A occurs via the retinoic acid-inducible gene-I-like receptors (RLRs) signaling pathway in the lung immune cells. F (more)

IRE1 Signaling As a Putative Therapeutic Target in Influenza Virus-induced Pneumonia.

Author(s): Schmoldt, Carole; Vazquez-Armendariz, Ana Ivonne; Shalashova, Irina; Selvakumar, Balachandar; Bremer, Corinna M; Peteranderl, Christin; Wasnick, Roxana; Witte, Biruta; Gattenlöhner, Stefan; Fink, Ludger; Vadász, István; Morty, Rory E; Pleschka, Stephan; Seeger, Werner; Günther, Andreas; Herold, Susanne
Source: Am J Respir Cell Mol Biol;61(4): 537-540, 2019 10.
MEDLINE - International Database for Medical Literature PMID: 31573336

Virus persistence in pig herds led to successive reassortment events between swine and human influenza A viruses, resulting in the emergence of a novel triple-reassortant swine influenza virus.

Author(s): Chastagner, Amélie; Bonin, Emilie; Fablet, Christelle; Quéguiner, Stéphane; Hirchaud, Edouard; Lucas, Pierrick; Gorin, Stéphane; Barbier, Nicolas; Béven, Véronique; Garin, Emmanuel; Blanchard, Yannick; Rose, Nicolas; Hervé, Séverine; Simon, Gaëlle
Source: Vet Res;50(1): 77, 2019 Oct 07.
MEDLINE - International Database for Medical Literature PMID: 31590684
Abstract: This report describes the detection of a triple reassortant swine influenza A virus of H1avN2 subtype. It evolved from an avian-like swine H1avN1 that first acquired the N2 segment from a seasonal H3N2, then the M segment from a 2009 pandemic H1N1, in two reassortments estimated to have occurred 10 years apart. This study illustrates how recurrent influenza infections increase the co-infection risk and facilitate evolutionary jumps by successive gene exchanges. It recalls the importance of (more)

Update: Influenza Activity - United States and Worldwide, May 19-September 28, 2019, and Composition of the 2020 Southern Hemisphere Influenza Vaccine.

Author(s): Epperson, Scott; Davis, C Todd; Brammer, Lynnette; Abd Elal, Anwar Isa; Ajayi, Noreen; Barnes, John; Budd, Alicia P; Burns, Erin; Daly, Peter; Dugan, Vivien G; Fry, Alicia M; Jang, Yunho; Johnson, Sara Jo; Kniss, Krista; Kondor, Rebecca; Grohskopf, Lisa A; Gubareva, Larisa; Merced-Morales, Angiezel; Sessions, Wendy; Stevens, James; Wentworth, David E; Xu, Xiyan; Jernigan, Daniel
Source: MMWR Morb Mortal Wkly Rep;68(40): 880-884, 2019 Oct 11.
MEDLINE - International Database for Medical Literature PMID: 31600182
Abstract: During May 19-September 28, 2019,* low levels of influenza activity were reported in the United States, with cocirculation of influenza A and influenza B viruses. In the Southern Hemisphere seasonal influenza viruses circulated widely, with influenza A(H3) predominating in many regions; however, influenza A(H1N1)pdm09 and influenza B viruses were predominant in some countries. In late September, the World Health Organization (WHO) recommended components for the 2020 Southern Hemisphere infl (more)

Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia.

Author(s): Sobolev, Ivan; Kurskaya, Olga; Leonov, Sergey; Kabilov, Marsel; Alikina, Tatyana; Alekseev, Alexander; Yushkov, Yuriy; Saito, Takehiko; Uchida, Yuko; Mine, Junki; Shestopalov, Alexander; Sharshov, Kirill
Source: Emerg Microbes Infect;8(1): 1456-1464, 2019.
MEDLINE - International Database for Medical Literature PMID: 31603050
Abstract: Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. There was a 10% identity difference between the HA and NA nucleotide sequences of isolated strains and the most phylogenetically related sequences (human influenza viruses of 1980s (more)
Results  1-12 de 3.191