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Results  1-12 de 9.160

RE: Impact of COVID-19 on a urology residency program

Author(s): Atan, Ali
Source: Int. braz. j. urol;47(4): 908-910, Jul.-Aug. 2021.
LILACS - Latin American and Caribbean Health Sciences ID: 1286790  LILACS Express

Boletim diário Covid-19: 21/03/2021 nº 360/ Covid-19 daily report: 03/21/2021 nº 360

Author(s): São Paulo (Cidade). Secretaria da Saúde
Source: São Paulo; SMS; 20210321.
LILACS - Latin American and Caribbean Health Sciences ID: 1178327

Antimicrobial and disinfectant resistance of Salmonella Heidelberg from Brazilian flocks did not increase for ten years (2006-2016)/ A resistência a desinfetantes e a antimicrobianos não aumentou em um período de 10 anos (2006 a 2016) em Salmonella Heidelberg isoladas de granjas avícolas brasileiras

Author(s): Bassani, Juliana; Paravisi, Mariana; Wilsmann, Daiane E; Borges, Karen A; Furian, Thales Q; Salle, Carlos T. P; Moraes, Hamilton L. S; Nascimento, Vladimir P
Source: Pesqui. vet. bras;41: e06818, 2021. tab, graf
LILACS - Latin American and Caribbean Health Sciences ID: 1340351
Abstract: Salmonella is a major cause of foodborne illness worldwide, and poultry and its derived products are the most common food products associated with salmonellosis outbreaks. Some countries, including Brazil, have experienced an increased prevalence of Salmonella Heidelberg among their poultry flocks. Some isolates have also presented high resistance to antimicrobial agents and persist in the poultry farm environment. This study aimed to compare the susceptibility of S. Heidelberg strains isol (more)

Predictores de mal pronóstico en pacientes con la COVID-19/ Predictors of poor prognosis in patients with COVID-19

Author(s): González Tabares, Rubén; Acosta González, Frank Abel; Oliva Villa, Evián; Rodríguez Reyes, Sandy Fidel; Cabeza Echevarría, Ivelyse
Source: Rev. cuba. med. mil;49(4): e918, tab
LILACS - Latin American and Caribbean Health Sciences ID: 1156512
Abstract: Introducción: La COVID-19 se ha caracterizado por un amplio espectro de manifestaciones y formas clínicas que comprenden desde enfermedad ligera hasta la muerte. Es de suma importancia identificar a aquellos con mayores probabilidades de desarrollar las complicaciones. Objetivo: Identificar factores de riesgo para desarrollar complicaciones en los pacientes atendidos con la COVID-19. Métodos: Fueron revisadas las 250 historias clínicas de pacientes ingresados por la COVID-19. Se rec (more)

Ethnobotany and ethnopharmacology of medicinal plants used in communities of the Soure Marine Extractive Reserve, Pará State, Brazil/ Etnobotánica y etnofarmacología de plantas medicinales utilizadas en las comunidades de la Reserva Extractiva Marina de Soure-Pará, Brasil

Author(s): Magno-Silva, Elis Ribeiro; Rocha, Tainá Teixeira; Tavares-Martins, Ana Cláudia Caldeira
Source: Bol. latinoam. Caribe plantas med. aromát;19(1): 29-64, ene. 2020. ilus, tab
LILACS - Latin American and Caribbean Health Sciences ID: 1102866
Abstract: The study of the relationship between man and nature can reveal the potential of plant resources. In the present study we used non-probabilistic sampling and snowball technique in communities of the Soure Marine Extractive Reserve-Pará, namely, Caju-Úna Community, Céu Settlement, and Pesqueiro Village, in order to analyze the medicinal plants used by these peoples, focusing on the diversity, consensual use and cultural importance of species, and providing ethnopharmacological information (more)

Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.

Author(s): Yuan, Yukang; Miao, Ying; Zeng, Chenhua; Liu, Jin; Chen, Xiangjie; Qian, Liping; Wang, Xiaofang; Qian, Feng; Yu, Zhengyuan; Wang, Jun; Qian, Guanghui; Fu, Qian; Lv, Haitao; Zheng, Hui
Source: Immunology;159(3): 309-321, 2020 03.
MEDLINE - International Database for Medical Literature PMID: 31691271
Abstract: Type-I interferons (IFN-I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the antiviral efficacy of IFN-I is largely restricted by negative regulators of IFN-I signaling in cells. Therefore, identification of intracellular inhibitors of IFN-I signaling is important for developing novel targets to improve IFN-I antiviral therapy. In this study, we report that the deubiquitinase ubiquitin-specific protease 7 (USP7) negatively regulates IFN-I-mediated anti (more)

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Author(s): Russier, Marion; Yang, Guohua; Briard, Benoit; Meliopoulos, Victoria; Cherry, Sean; Kanneganti, Thirumala-Devi; Schultz-Cherry, Stacey; Vogel, Peter; Russell, Charles J
Source: J Virol;94(3)2020 Jan 17.
MEDLINE - International Database for Medical Literature PMID: 31694942
Abstract: Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) virus (activation pH, 5.5). The extracellular lung pH was measured to be near neutral ( (more)

Antiviral Activity of Fritillaria thunbergii Extract against Human Influenza Virus H1N1 (PR8) In Vitro, In Ovo and In Vivo.

Author(s): Kim, Minjee; Nguyen, Dinh-Van; Heo, Yoonki; Park, Ki Hoon; Paik, Hyun-Dong; Kim, Young Bong
Source: J Microbiol Biotechnol;30(2): 172-177, 2020 Feb 28.
MEDLINE - International Database for Medical Literature PMID: 31752057
Abstract: Influenza viruses cause respiratory diseases in humans and animals with high morbidity and mortality rates. Conventional anti-influenza drugs are reported to exert side effects and newly emerging viral strains tend to develop resistance to these commonly used agents. Fritillaria thunbergii (FT) is traditionally used as an expectorant for controlling airway inflammatory disorders. Here, we evaluated the therapeutic effects of FT extracts against influenza virus type A (H1N1) infection in vit (more)

Source of oseltamivir resistance due to single E119D and double E119D/H274Y mutations in pdm09H1N1 influenza neuraminidase.

Author(s): Hanpaibool, Chonnikan; Leelawiwat, Matina; Takahashi, Kaito; Rungrotmongkol, Thanyada
Source: J Comput Aided Mol Des;34(1): 27-37, 2020 Jan.
MEDLINE - International Database for Medical Literature PMID: 31773463
Abstract: Influenza epidemics are responsible for an average of 3-5 millions of severe cases and up to 500,000 deaths around the world. One of flu pandemic types is influenza A(H1N1)pdm09 virus (pdm09H1N1). Oseltamivir is the antiviral drug used to treat influenza targeting at neuraminidase (NA) located on the viral surface. Influenza virus undergoes high mutation rates and leads to drug resistance, and thus the development of more efficient drugs is required. In the present study, all-atom molecular (more)

Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264.7 cells.

Author(s): Tian, Jing; Qu, Na; Jiao, Xue; Wang, Xiaonan; Geng, Jin; Griffin, Noreen; Shan, Fengping
Source: Int Immunopharmacol;78: 106032, 2020 Jan.
MEDLINE - International Database for Medical Literature PMID: 31835089
Abstract: MENK, as an immune adjuvant, has potential immune-regulatory activity on innate and adaptive immune cells. The aim of this work was to investigate the antiviral effect of MENK on influenza virus-infected murine macrophage cells (RAW264.7) and its underlying mechanisms. The results showed that MENK markedly inhibited influenza A virus (H1N1) replication in pre- and post-MENK treatment, especially in pre-MENK treatment. The mechanisms exploration revealed that MENK (10 mg/mL) significant (more)

Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis.

Author(s): Berkebile, Abigail R; Bartlett, Jennifer A; Abou Alaiwa, Mahmoud; Varga, Steven M; Power, Ultan F; McCray, Paul B
Source: Am J Respir Cell Mol Biol;62(1): 104-111, 2020 01.
MEDLINE - International Database for Medical Literature PMID: 31242392
Abstract: Although chronic bacterial infections and inflammation are associated with progressive lung disease in patients with cystic fibrosis (CF), much less is known regarding the contributions of respiratory viral infections to this process. Clinical studies suggest that antiviral host defenses may be compromised in individuals with CF, and CF airway epithelia exhibit impaired antiviral responses in vitro. Here, we used the CF pig model to test the hypothesis that the antiviral activity of respira (more)
Results  1-12 de 9.160