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Results  1-12 de 10.967
2.

Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons

Author(s): Machado, Clarisse M; de Souza, Ana Carolina Mamana Fernandes; Romano, Camila Malta; dos Santos Freire, Wilton; Costa, Ângela Aparecida; Figueiredo, Walter Manso; Pannuti, Cláudio S; Luna, Expedito J A
Source: Braz. j. infect. dis;24(1): 73-80, Feb. 2020. tab, graf
LILACS - Latin American and Caribbean Health Sciences ID: 1089322
Abstract: ABSTRACT Introduction Influenza is an important cause of morbimortality worldwide. Although people at the extremes of age have a greater risk of complications, influenza has been more frequently investigated in the elderly than in children, and inpatients than outpatients. Yearly vaccination with trivalent or quadrivalent vaccines is the main strategy to control influenza. Objectives Determine the clinical and molecular characteristics of influenza A and B infections in children and adole (more)
Subject(s): Humans Male Female Infant Child, Preschool Child Young Adult Influenza A virus/genetics Influenza B virus/genetics Outpatients/statistics & numerical data Influenza, Human/virology Phylogeny Respiratory Tract Infections/epidemiology Respiratory Tract Infections/virology Seasons Time Factors Brazil/epidemiology Influenza Vaccines Prospective Studies Follow-Up Studies Statistics, Nonparametric Influenza, Human/prevention & control Influenza, Human/epidemiology
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3.

Influenza A(H1N1)pdm09 infection and viral load analysis in patients with different clinical presentations

Author(s): Disciplina de Infectologia, Laboratório de Virologia ClínicaRodrigues Guimarães Alves, Vitória; Perosa, Ana Helena; Disciplina de Infectologia, Laboratório de Virologia Clínicade Souza Luna, Luciano Kleber; Disciplina de Infectologia, Laboratório de Virologia ClínicaCruz, Jessica Santiago; Disciplina de Infectologia, Laboratório de Virologia ClínicaConte, Danielle Dias; Disciplina de Infectologia, Laboratório de Virologia ClínicaBellei, Nancy
Source: Mem. Inst. Oswaldo Cruz;115: e200009, 2020. tab, graf
LILACS - Latin American and Caribbean Health Sciences ID: 1135259
Abstract: BACKGROUND Influenza viral load (VL) can be a decisive factor in determining the antiviral efficacy in viral clearance. OBJECTIVE This study aimed to evaluate the rate of infection and the role of influenza VL on the clinical spectrum of illnesses among different patient groups attended at a tertiary hospital in Brazil. METHODS Samples were collected from patients presenting acute respiratory infection from 2009 to 2013. Overall, 2262 samples were analysed and distributed into three gr (more)
Subject(s): Humans Male Female Infant, Newborn Infant Child, Preschool Child Adolescent Adult Aged Young Adult Respiratory Tract Infections/virology Influenza, Human/virology Influenza A Virus, H1N1 Subtype/genetics RNA, Viral/genetics Acute Disease Viral Load Influenza A Virus, H1N1 Subtype/classification Influenza A Virus, H1N1 Subtype/pathogenicity Real-Time Polymerase Chain Reaction Middle Aged
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4.

Identification of SARS-CoV-2 and additional respiratory pathogens cases under the investigation of COVID-19 initial phase in a Brazilian reference laboratory

Author(s): Laboratório de Vírus Respiratórios e do SarampoMatos, Aline da Rocha; Laboratório de Vírus Respiratórios e do SarampoMotta, Fernando Couto; Laboratório de Vírus Respiratórios e do SarampoCaetano, Braulia Costa; Laboratório de Vírus Respiratórios e do SarampoOgrzewalska, Maria; Laboratório de Vírus Respiratórios e do SarampoGarcia, Cristiana Couto; Laboratório de Vírus Respiratórios e do SarampoLopes, Jonathan Christian Oliveira; Laboratório de Vírus Respiratórios e do SarampoMiranda, Milene; Coordenação-Geral de LaboratóriosLivorati, Miriam Teresinha Furlam Prando; Coordenação-Geral de LaboratóriosAbreu, André; Laboratório de Vírus Respiratórios e do SarampoBrown, David; Laboratório de Vírus Respiratórios e do SarampoSiqueira, Marilda Mendonça
Source: Mem. Inst. Oswaldo Cruz;115: e200232, 2020. tab
LILACS - Latin American and Caribbean Health Sciences ID: 1135221
Abstract: Coronavirus disease 2019 (COVID-19) surveillance, in Brazil, initiated shortly after its description, in China. Our aim was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional pathogens in samples from the initial phase of the outbreak in Brazil, from late February to late March. From 707 samples analysed, 29 (4.1%) were SARS-CoV-2 positive. Fever and cough were their most prevalent symptoms. Co-detection of rhinovirus was observed in 2 (6.9%) cases. Additi (more)
Subject(s): Humans Pneumonia, Viral/diagnosis Coronavirus Infections/diagnosis Betacoronavirus/isolation & purification Pneumonia, Viral/epidemiology Rhinovirus/isolation & purification Brazil/epidemiology China Coronavirus Infections/epidemiology Diagnosis, Differential Influenza A Virus, H1N1 Subtype/isolation & purification Pandemics SARS-CoV-2 COVID-19
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5.

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Author(s): Ivan, Fransiskus X; Zhou, Xinrui; Lau, Suk Hiang; Rashid, Shamima; Teo, Jasmine S M; Lee, Hong Kai; Koay, Evelyn S; Chan, Kwai Peng; Leo, Yee Sin; Chen, Mark I C; Kwoh, Chee Keong; Chow, Vincent T
Source: Int J Infect Dis;90: 84-96, 2020 Jan.
MEDLINE - International Database for Medical Literature PMID: 31669593
Abstract: BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. METHODS: The complete genomes of influenza A/H1N1, A/H3N2 and B viruses that caused mild infections among outpatients and severe infections among inpatients in Singapore during 2012-2015 were sequenced and characterized. Using various bioinfo (more)
Subject(s): Evolution, Molecular Influenza A Virus, H1N1 Subtype/genetics Influenza A Virus, H3N2 Subtype/genetics Influenzavirus B/genetics Adolescent Adult Aged Hemagglutinin Glycoproteins, Influenza Virus/chemistry Hemagglutinin Glycoproteins, Influenza Virus/genetics Hospitalization Humans Influenza, Human/virology Middle Aged Mutation Neuraminidase/genetics Outpatients Phylogeny Receptors, Virus/chemistry Singapore Viral Proteins/genetics Young Adult
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6.

Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.

Author(s): Yuan, Yukang; Miao, Ying; Zeng, Chenhua; Liu, Jin; Chen, Xiangjie; Qian, Liping; Wang, Xiaofang; Qian, Feng; Yu, Zhengyuan; Wang, Jun; Qian, Guanghui; Fu, Qian; Lv, Haitao; Zheng, Hui
Source: Immunology;159(3): 309-321, 2020 03.
MEDLINE - International Database for Medical Literature PMID: 31691271
Abstract: Type-I interferons (IFN-I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the antiviral efficacy of IFN-I is largely restricted by negative regulators of IFN-I signaling in cells. Therefore, identification of intracellular inhibitors of IFN-I signaling is important for developing novel targets to improve IFN-I antiviral therapy. In this study, we report that the deubiquitinase ubiquitin-specific protease 7 (USP7) negatively regulates IFN-I-mediated anti (more)
Subject(s): Antiviral Agents/pharmacology Enzyme Inhibitors/pharmacology Influenza A Virus, H1N1 Subtype/drug effects Interferon-alpha/pharmacology Suppressor of Cytokine Signaling 1 Protein/metabolism Thiophenes/pharmacology Ubiquitin-Specific Peptidase 7/antagonists & inhibitors Vesiculovirus/drug effects A549 Cells HEK293 Cells HeLa Cells Host-Pathogen Interactions Humans Influenza A Virus, H1N1 Subtype/immunology Influenza A Virus, H1N1 Subtype/pathogenicity Janus Kinases/metabolism Protein Binding Protein Stability Proteolysis Signal Transduction Suppressor of Cytokine Signaling 1 Protein/genetics Time Factors Ubiquitin-Specific Peptidase 7/metabolism Ubiquitination Vesiculovirus/immunology Vesiculovirus/pathogenicity
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7.

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Author(s): Russier, Marion; Yang, Guohua; Briard, Benoit; Meliopoulos, Victoria; Cherry, Sean; Kanneganti, Thirumala-Devi; Schultz-Cherry, Stacey; Vogel, Peter; Russell, Charles J
Source: J Virol;94(3)2020 Jan 17.
MEDLINE - International Database for Medical Literature PMID: 31694942
Abstract: Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) virus (activation pH, 5.5). The extracellular lung pH was measured to be near neutral ( (more)
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8.

Dendritic Cells Targeting Lactobacillus plantarum Strain NC8 with a Surface-Displayed Single-Chain Variable Fragment of CD11c Induce an Antigen-Specific Protective Cellular Immune Response.

Author(s): Liu, Jing; Yang, Guilian; Huang, Haibin; Shi, Chunwei; Gao, Xing; Yang, Wentao; Zhang, Zan; Liu, Yang; Xu, Ke; Wang, Jianzhong; Kang, Yuanhuan; Jiang, Yanlong; Wang, Chunfeng
Source: Infect Immun;88(2)2020 01 22.
MEDLINE - International Database for Medical Literature PMID: 31740528
Abstract: Influenza A virus (H1N1) is an acute, highly contagious respiratory virus. The use of lactic acid bacteria (LAB) to deliver mucosal vaccines against influenza virus infection is a research hot spot. In this study, two recombinant Lactobacillus plantarum strains expressing hemagglutinin (HA) alone or coexpressing aCD11c-HA to target HA protein to dendritic cells (DCs) by fusion to an anti-CD11c single-chain antibody (aCD11c) were constructed. The activation of bone marrow dendritic cells (BM (more)
Subject(s): CD11c Antigen/immunology Dendritic Cells/immunology Immunity, Cellular/immunology Lactobacillus plantarum/immunology Single-Chain Antibodies/immunology Animals Antibodies, Neutralizing/immunology CD4-Positive T-Lymphocytes/immunology CD4-Positive T-Lymphocytes/virology CD8-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/virology Dendritic Cells/virology Female Influenza A Virus, H1N1 Subtype/immunology Interferon-gamma/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Orthomyxoviridae Infections/immunology Orthomyxoviridae Infections/virology
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9.

Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase.

Author(s): Evseenko, Vasily A; Svyatchenko, Svetlana V; Kolosova, Natalia P; Kovrizhkina, Valentina L; Marchenko, Vasiliy Y; Durymanov, Aleksander G; Goncharova, Natalia I; Ryzhikov, Alexander B
Source: Arch Virol;165(1): 201-206, 2020 Jan.
MEDLINE - International Database for Medical Literature PMID: 31745716
Abstract: Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT50) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT50 was observed with the seasonal human H3N2 virus (45.5 °C). The IT50 values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon I (more)
Subject(s): Influenzavirus A/enzymology Influenzavirus B/enzymology Neuraminidase/chemistry Animals Birds/virology Body Temperature Enzyme Stability Humans Swine Thermodynamics Viral Proteins/chemistry Zoonoses/virology
Link(s):
10.

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans.

Author(s): Rijal, Pramila; Wang, Bei Bei; Tan, Tiong Kit; Schimanski, Lisa; Janesch, Philipp; Dong, Tao; McCauley, John W; Daniels, Rodney S; Townsend, Alain R; Huang, Kuan-Ying A
Source: J Virol;94(4)2020 Jan 31.
MEDLINE - International Database for Medical Literature PMID: 31748388
Abstract: The majority of antibodies induced by influenza neuraminidase (NA), like those against hemagglutinin (HA), are relatively specific to viruses isolated within a limited time window, as seen in serological studies and the analysis of many murine monoclonal antibodies (MAbs). We report three broadly reactive human MAbs targeting N1 NA. Two were isolated from a young adult vaccinated with trivalent influenza vaccine (TIV), which inhibited N1 NA from viruses isolated from humans over a period of (more)
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11.

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Author(s): Smith, Andrew; Rodriguez, Laura; El Ghouayel, Maya; Nogales, Aitor; Chamberlain, Jeffrey M; Sortino, Katherine; Reilly, Emma; Feng, Changyong; Topham, David J; Martínez-Sobrido, Luis; Dewhurst, Stephen
Source: J Virol;94(4)2020 Jan 31.
MEDLINE - International Database for Medical Literature PMID: 31748399
Abstract: Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based, contains either the internal genes of the 1960 A/Ann Arbor/6/60 or the 1957 A/Leningrad/17/57 H2N2 viruses (i.e., they diverge considerably from currently circulating strains). We previously sh (more)
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12.

Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.

Author(s): Rodriguez-Frandsen, Ariel; Martin-Sancho, Laura; Gounder, Anshu P; Chang, Max W; Liu, Wen-Chun; De Jesus, Paul D; von Recum-Knepper, Jessica; Dutra, Miriam S; Huffmaster, Nicholas J; Chavarria, Monica; Mena, Ignacio; Riva, Laura; Nguyen, Courtney B; Dobariya, Saunil; Herbert, Kristina M; Benner, Christopher; Albrecht, Randy A; García-Sastre, Adolfo; Chanda, Sumit K
Source: J Virol;94(4)2020 Jan 31.
MEDLINE - International Database for Medical Literature PMID: 31776276
Abstract: Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, as well as sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different species is, in part, dictated by its ability to exploit the genetic environment of the host cell. To investigate IAV tropism in human cells, we evaluated the replication of IAV strains in a diverse subset of epithelial cell lines. HeLa cells were refractory to the growth of human H1 (more)
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Results  1-12 de 10.967
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