Search | Influenza A(H1N1)

Influenza A(H1N1) > Search > Virology

Export RSS XML

Order by

Refine your search

Hide all

Show all

Type

Article (10882)
Video and audio (20)
Guidances (16)
Information for the public (8)
Hotsites (4)
Frequently Answered Questions-FAQ (3)
Thesis (3)
Epidemiological Reports (2)
News (2)
Leaflets and Posters (1)
Electronic Publications - government document (1)
Twitter (1)

Thematic areas

Virology (10948)
Therapy (4165)
Epidemiology (3909)
Control and Prevention (2893)
Diagnosis (1591)
Pandemic (1143)

Fulltext (8386)

Main subject

Influenza, Human (6818)
Influenza A Virus, H1N1 Subtype (6607)
Orthomyxoviridae Infections (1862)
Influenza Vaccines (1476)
Influenza A virus (1347)
Antiviral Agents (1083)
Disease Outbreaks (1077)
Pandemics (963)
Influenza A Virus, H3N2 Subtype (961)
Hemagglutinin Glycoproteins, Influenza Virus (639)
Swine Diseases (538)
Influenza B virus (486)
Neuraminidase (485)
Antibodies, Viral (483)
Oseltamivir (415)
Viral Proteins (374)
Orthomyxoviridae (330)
Drug Resistance, Viral (306)
Respiratory Tract Infections (265)
Virus Replication (244)
Show more...

Journal

Language

English (10133)
Spanish (170)
French (106)
Portuguese (86)
German (34)
Italian (11)
Show more...

Year

2011 (1620)
2010 (1435)
2012 (1230)
2013 (1028)
2014 (835)
2009 (802)
2015 (695)
2016 (590)
2018 (556)
2017 (539)
2019 (366)
2008 (194)
2007 (165)
2006 (147)
2004 (106)
2005 (93)
2002 (86)
2003 (84)
2000 (81)
2001 (76)
Show more...

Send by email

Results 1-12 de 10.948

<< First < Previous 01 02 03 04 05 06 07 08 09 10 Next >

Serum expression of microRNA-16 in a cohort of Egyptian patients with ulcerative colitis and its correlation with disease extent and severity/ Expressão sérica do microRNA-16 em uma coorte de pacientes egípcios com colite ulcerosa e sua correlação com a extensão e gravidade da doença

Author(s): Saad, Hussein Mahmoud; Ali, Ezzat; Baddour, Nahed; Ibrahim, Mohamed Eid; Tayae, Eman

Source: J. coloproctol. (Rio J., Impr.);40(3): 253-260, July-Sept. 2020. tab, graf

LILACS - Latin American and Caribbean Health Sciences ID: 1134986

Abstract: Abstract Ulcerative colitis is one of the IBDs. Its etiology and pathogenesis remain undefined with an interaction between environmental, genetic and immunological factors is the most accepted explanation. Several recent studies have examined microRNA expression in the peripheral blood and tissues from IBD patients. The study aims at assessing the expression of serum miR-16 in ulcerative colitis patients and its correlation with disease extent, activity and severity. It included 30 treatmen (more) t naïve ulcerative colitis patients of different presentations. Serum miR-16 expression was assessed using reverse transcriptase quantitative real time PCR (RT-qPCR), and then correlated with that of a group of 20 healthy subjects to assess its role in diagnosis of ulcerative colitis. Also, it was correlated with disease extent (proctitis, left sided colitis, extensive colitis) and disease activity and severity indices (Truelove and Witts criteria, fecal calprotectin and UCEIS). Thirty ulcerative colitis patients were enrolled, 53% had mild, 37% had moderate, while 10% had severe disease. Concerning endoscopic extent, 8 had proctitis, 14 had left sided colitis and 8 had extensive colitis. Serum expression of miR-16 in the 30 patients were compared to that of the healthy control subjects. The patients' group showed median serum miR-16 expression of 1.91, 1.13 for the control group with a significant difference between both groups. Correlation between serum miR-16 expression with disease extent, activity and severity showed no significant relation. From the current study we can conclude that increased serum expression of miR-16 is associated with ulcerative colitis despite no significant relation to disease activity extent or severity.

Resumo A colite ulcerativa é uma das DII. Sua etiologia e patogênese permanecem indefinidas; a interação entre fatores ambientais, genéticos e imunológicos é a explicação mais aceita. Vários estudos recentes avaliaram a expressão de microRNA no sangue e tecidos periféricos em pacientes com DII. O presente estudo teve como objetivo avaliar a expressão do miR-16 sérico em pacientes com colite ulcerativa e sua correlação com a extensão, atividade e gravidade da doença. Foram incluídos 30 pacientes de colite ulcerativa, com diferentes apresentações, que ainda não haviam sido submetidos a nenhum tipo de tratamento. A expressão sérica de miR-16 foi avaliada usando transcrição reversa seguida de reação em cadeia da polimerase quantitativa (RT-qPCR) e, em seguida, correlacionada com a de um grupo de 20 indivíduos saudáveis para avaliar seu papel no diagnóstico de colite ulcerativa. Além disso, foi feita uma correlação com a extensão da doença (proctite, colite do lado esquerdo, colite extensa) e com os índices de atividade e gravidade da doença (critérios de Truelove e Witts, calprotectina fecal e UCEIS). Trinta pacientes com colite ulcerativa foram incluídos no estudo, classificada como leve em 53%, moderada em 37% e grave em 10%. Quanto à extensão endoscópica, oito apresentavam proctite, 14 apresentavam colite do lado esquerdo e oito apresentavam colite extensa. A expressão sérica de miR-16 nos 30 pacientes foi comparada à dos indivíduos controle saudáveis. No, grupo de pacientes, a expressão sérica de miR-16 foi de 1,91 (grupo controle: 1,13), uma diferença estatisticamente significativa entre os dois grupos. Não foi observada relação significativa entre a expressão sérica de miR-16 e a extensão, atividade e gravidade da doença. A partir do presente estudo, pode-se concluir que o aumento da expressão sérica do miR-16 está associado à colite ulcerativa, apesar de não haver relação significativa com a extensão ou gravidade da atividade da doença.

Subject(s): Humans Male Female Colitis, Ulcerative/genetics Colitis, Ulcerative/pathology MicroRNAs Inflammatory Bowel Diseases Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription Real-Time Polymerase Chain Reaction

Link(s):

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632020000300253

Consumo alimentar de pacientes renais crônicos submetidos à diálise peritoneal e fatores associados/ Food intake by chronic kidney patients undergoing peritoneal dialysis and associated factors

Author(s): Alcântara, Fernanda Godinho de; Freitas, Marinilda Simões; Furriel, Aparecida Ferreira; Cattafesta, Monica; Salaroli, Luciane Bresciani

Source: Saude e pesqui. (Impr.);13(1): 63-72, jan/mar 2020. ilus, tab

LILACS - Latin American and Caribbean Health Sciences ID: 1052900

Abstract: O objetivo deste estudo foi avaliar o consumo alimentar e fatores associados de pacientes com Doença Renal Crônica em terapia renal substitutiva do tipo diálise peritoneal. Trata-se de um estudo transversal que avaliou dados sociodemográficos, hábitos de vida, estado nutricional e condição clínica com o consumo alimentar destes pacientes. Dos indivíduos avaliados, 73,5% (n=25) apresentaram consumo fora do recomendado de calorias e carboidratos, 76,5% (n=32) de proteína e 52,95% (n (more)

Subject(s): Humans Male Female Adult Middle Aged Aged Aged, 80 and over Socioeconomic Factors Eating Peritoneal Dialysis Renal Insufficiency, Chronic

Link(s):

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Author(s): Ivan, Fransiskus X; Zhou, Xinrui; Lau, Suk Hiang; Rashid, Shamima; Teo, Jasmine S M; Lee, Hong Kai; Koay, Evelyn S; Chan, Kwai Peng; Leo, Yee Sin; Chen, Mark I C; Kwoh, Chee Keong; Chow, Vincent T

Source: Int J Infect Dis;90: 84-96, 2020 Jan.

MEDLINE - International Database for Medical Literature PMID: 31669593

Abstract: BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. METHODS: The complete genomes of influenza A/H1N1, A/H3N2 and B viruses that caused mild infections among outpatients and severe infections among inpatients in Singapore during 2012-2015 were sequenced and characterized. Using various bioinfo (more)

Link(s):

https://dx.doi.org/10.1016/j.ijid.2019.10.024

Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.

Author(s): Yuan, Yukang; Miao, Ying; Zeng, Chenhua; Liu, Jin; Chen, Xiangjie; Qian, Liping; Wang, Xiaofang; Qian, Feng; Yu, Zhengyuan; Wang, Jun; Qian, Guanghui; Fu, Qian; Lv, Haitao; Zheng, Hui

Source: Immunology;159(3): 309-321, 2020 03.

MEDLINE - International Database for Medical Literature PMID: 31691271

Abstract: Type-I interferons (IFN-I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the antiviral efficacy of IFN-I is largely restricted by negative regulators of IFN-I signaling in cells. Therefore, identification of intracellular inhibitors of IFN-I signaling is important for developing novel targets to improve IFN-I antiviral therapy. In this study, we report that the deubiquitinase ubiquitin-specific protease 7 (USP7) negatively regulates IFN-I-mediated anti (more)

Subject(s): Antiviral Agents/pharmacology Enzyme Inhibitors/pharmacology Influenza A Virus, H1N1 Subtype/drug effects Interferon-alpha/pharmacology Suppressor of Cytokine Signaling 1 Protein/metabolism Thiophenes/pharmacology Ubiquitin-Specific Peptidase 7/antagonists & inhibitors Vesiculovirus/drug effects A549 Cells HEK293 Cells HeLa Cells Host-Pathogen Interactions Humans Influenza A Virus, H1N1 Subtype/immunology Influenza A Virus, H1N1 Subtype/pathogenicity Janus Kinases/metabolism Protein Binding Protein Stability Proteolysis Signal Transduction Suppressor of Cytokine Signaling 1 Protein/genetics Time Factors Ubiquitin-Specific Peptidase 7/metabolism Ubiquitination Vesiculovirus/immunology Vesiculovirus/pathogenicity

Link(s):

https://dx.doi.org/10.1111/imm.13147

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Author(s): Russier, Marion; Yang, Guohua; Briard, Benoit; Meliopoulos, Victoria; Cherry, Sean; Kanneganti, Thirumala-Devi; Schultz-Cherry, Stacey; Vogel, Peter; Russell, Charles J

Source: J Virol;94(3)2020 Jan 17.

MEDLINE - International Database for Medical Literature PMID: 31694942

Abstract: Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) virus (activation pH, 5.5). The extracellular lung pH was measured to be near neutral ( (more) pH 6.9 to 7.5). WT and Y17H viruses had similar environmental stability at pH 7.0; thus, extracellular inactivation was unlikely to attenuate the Y17H virus. The Y17H virus had accelerated replication kinetics in MDCK, A549, and RAW 264.7 cells when inoculated at a multiplicity of infection (MOI) of 3 PFU/cell. The destabilizing mutation also increased early infectivity and type I interferon (IFN) responses in mouse bone marrow-derived dendritic cells (DCs). In contrast, the HA-Y17H mutation reduced virus replication in murine airway murine nasal epithelial cell and murine tracheal epithelial cell cultures and attenuated virus replication, virus spread, the severity of infection, and cellular infiltration in the lungs of mice. Normalizing virus infection and weight loss in mice by inoculating them with Y17H virus at a dose 500-fold higher than that of WT virus revealed that the destabilized mutant virus triggered the upregulation of more host genes and increased type I IFN responses and cytokine expression in DBA/2 mouse lungs. Overall, HA destabilization decreased virulence in mice by boosting early infection in DCs, resulting in the greater activation of antiviral responses, including the type I IFN response. These studies reveal that HA stability may regulate pathogenicity by modulating IFN responses.IMPORTANCE Diverse influenza A viruses circulate in wild aquatic birds, occasionally infecting farm animals. Rarely, an avian- or swine-origin influenza virus adapts to humans and starts a pandemic. Seasonal and many universal influenza vaccines target the HA surface protein, which is a key component of pandemic influenza viruses. Understanding the HA properties needed for replication and pathogenicity in mammals may guide response efforts to control influenza. Some antiviral drugs and broadly reactive influenza vaccines that target the HA protein have suffered resistance due to destabilizing HA mutations that do not compromise replicative fitness in cell culture. Here, we show that despite not compromising fitness in standard cell cultures, a destabilizing H1N1 HA stalk mutation greatly diminishes viral replication and pathogenicity in vivo by modulating type I IFN responses. This encourages targeting the HA stalk with antiviral drugs and vaccines as well as reevaluating previous candidates that were susceptible to destabilizing resistance mutations.

Link(s):

https://dx.doi.org/10.1128/JVI.01423-19

Dendritic Cells Targeting Lactobacillus plantarum Strain NC8 with a Surface-Displayed Single-Chain Variable Fragment of CD11c Induce an Antigen-Specific Protective Cellular Immune Response.

Author(s): Liu, Jing; Yang, Guilian; Huang, Haibin; Shi, Chunwei; Gao, Xing; Yang, Wentao; Zhang, Zan; Liu, Yang; Xu, Ke; Wang, Jianzhong; Kang, Yuanhuan; Jiang, Yanlong; Wang, Chunfeng

Source: Infect Immun;88(2)2020 01 22.

MEDLINE - International Database for Medical Literature PMID: 31740528

Abstract: Influenza A virus (H1N1) is an acute, highly contagious respiratory virus. The use of lactic acid bacteria (LAB) to deliver mucosal vaccines against influenza virus infection is a research hot spot. In this study, two recombinant Lactobacillus plantarum strains expressing hemagglutinin (HA) alone or coexpressing aCD11c-HA to target HA protein to dendritic cells (DCs) by fusion to an anti-CD11c single-chain antibody (aCD11c) were constructed. The activation of bone marrow dendritic cells (BM (more)

Link(s):

https://dx.doi.org/10.1128/IAI.00759-19

Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase.

Author(s): Evseenko, Vasily A; Svyatchenko, Svetlana V; Kolosova, Natalia P; Kovrizhkina, Valentina L; Marchenko, Vasiliy Y; Durymanov, Aleksander G; Goncharova, Natalia I; Ryzhikov, Alexander B

Source: Arch Virol;165(1): 201-206, 2020 Jan.

MEDLINE - International Database for Medical Literature PMID: 31745716

Abstract: Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT50) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT50 was observed with the seasonal human H3N2 virus (45.5 °C). The IT50 values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon I (more)

Subject(s): Influenzavirus A/enzymology Influenzavirus B/enzymology Neuraminidase/chemistry Animals Birds/virology Body Temperature Enzyme Stability Humans Swine Thermodynamics Viral Proteins/chemistry Zoonoses/virology

Link(s):

https://dx.doi.org/10.1007/s00705-019-04465-w

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans.

Author(s): Rijal, Pramila; Wang, Bei Bei; Tan, Tiong Kit; Schimanski, Lisa; Janesch, Philipp; Dong, Tao; McCauley, John W; Daniels, Rodney S; Townsend, Alain R; Huang, Kuan-Ying A

Source: J Virol;94(4)2020 Jan 31.

MEDLINE - International Database for Medical Literature PMID: 31748388

Abstract: The majority of antibodies induced by influenza neuraminidase (NA), like those against hemagglutinin (HA), are relatively specific to viruses isolated within a limited time window, as seen in serological studies and the analysis of many murine monoclonal antibodies (MAbs). We report three broadly reactive human MAbs targeting N1 NA. Two were isolated from a young adult vaccinated with trivalent influenza vaccine (TIV), which inhibited N1 NA from viruses isolated from humans over a period of (more)

Link(s):

https://dx.doi.org/10.1128/JVI.01182-19

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Author(s): Smith, Andrew; Rodriguez, Laura; El Ghouayel, Maya; Nogales, Aitor; Chamberlain, Jeffrey M; Sortino, Katherine; Reilly, Emma; Feng, Changyong; Topham, David J; Martínez-Sobrido, Luis; Dewhurst, Stephen

Source: J Virol;94(4)2020 Jan 31.

MEDLINE - International Database for Medical Literature PMID: 31748399

Abstract: Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based, contains either the internal genes of the 1960 A/Ann Arbor/6/60 or the 1957 A/Leningrad/17/57 H2N2 viruses (i.e., they diverge considerably from currently circulating strains). We previously sh (more)

Link(s):

https://dx.doi.org/10.1128/JVI.01065-19

10.

Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.

Author(s): Rodriguez-Frandsen, Ariel; Martin-Sancho, Laura; Gounder, Anshu P; Chang, Max W; Liu, Wen-Chun; De Jesus, Paul D; von Recum-Knepper, Jessica; Dutra, Miriam S; Huffmaster, Nicholas J; Chavarria, Monica; Mena, Ignacio; Riva, Laura; Nguyen, Courtney B; Dobariya, Saunil; Herbert, Kristina M; Benner, Christopher; Albrecht, Randy A; García-Sastre, Adolfo; Chanda, Sumit K

Source: J Virol;94(4)2020 Jan 31.

MEDLINE - International Database for Medical Literature PMID: 31776276

Abstract: Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, as well as sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different species is, in part, dictated by its ability to exploit the genetic environment of the host cell. To investigate IAV tropism in human cells, we evaluated the replication of IAV strains in a diverse subset of epithelial cell lines. HeLa cells were refractory to the growth of human H1 (more) N1 and H3N2 viruses and low-pathogenic avian influenza (LPAI) viruses. Interestingly, a human isolate of the highly pathogenic avian influenza (HPAI) H5N1 virus successfully propagated in HeLa cells to levels comparable to those in a human lung cell line. Heterokaryon cells generated by fusion of HeLa and permissive cells supported H1N1 virus growth, suggesting the absence of a host factor(s) required for the replication of H1N1, but not H5N1, viruses in HeLa cells. The absence of this factor(s) was mapped to reduced nuclear import, replication, and translation, as well as deficient viral budding. Using reassortant H1N1:H5N1 viruses, we found that the combined introduction of nucleoprotein (NP) and hemagglutinin (HA) from an H5N1 virus was necessary and sufficient to enable H1N1 virus growth. Overall, this study suggests that the absence of one or more cellular factors in HeLa cells results in abortive replication of H1N1, H3N2, and LPAI viruses, which can be circumvented upon the introduction of H5N1 virus NP and HA. Further understanding of the molecular basis of this restriction will provide important insights into the virus-host interactions that underlie IAV pathogenesis and tropism.IMPORTANCE Many zoonotic avian influenza A viruses have successfully crossed the species barrier and caused mild to life-threatening disease in humans. While human-to-human transmission is limited, there is a risk that these zoonotic viruses may acquire adaptive mutations enabling them to propagate efficiently and cause devastating human pandemics. Therefore, it is important to identify viral determinants that provide these viruses with a replicative advantage in human cells. Here, we tested the growth of influenza A virus in a subset of human cell lines and found that abortive replication of H1N1 viruses in HeLa cells can be circumvented upon the introduction of H5N1 virus HA and NP. Overall, this work leverages the genetic diversity of multiple human cell lines to highlight viral determinants that could contribute to H5N1 virus pathogenesis and tropism.

Link(s):

https://dx.doi.org/10.1128/JVI.01410-19

11.

Influenza Virus Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: N-Glycan Subtypes in Host-Pathogen Interactions.

Author(s): Parsons, Lisa M; An, Yanming; Qi, Li; White, Mitchell R; van der Woude, Roosmarijn; Hartshorn, Kevan L; Taubenberger, Jeffery K; de Vries, Robert P; Cipollo, John F

Source: J Virol;94(5)2020 Feb 14.

MEDLINE - International Database for Medical Literature PMID: 31826991

Abstract: Seasonal influenza carrying key hemagglutinin (HA) head region glycosylation sites can be removed from the lung by pulmonary surfactant protein D (SP-D). Little is known about HA head glycosylation of low-pathogenicity avian influenza virus (LPAIV) subtypes. These can pose a pandemic threat through reassortment and emergence in human populations. Since the presence of head region high-mannose glycosites dictates SP-D activity, the ability to predict these glycosite glycan subtypes may be of (more) value. Here, we investigate the activities of two recombinant human SP-D forms against representative LPAIV strains, including H2N1, H5N1, H6N1, H11N9, an avian H3N8, and a human seasonal H3N2 subtype. Using mass spectrometry, we determined the glycan subclasses and heterogeneities at each head glycosylation site. Sequence alignment and molecular structure analysis of the HAs were performed for LPAIV strains in comparison to seasonal H3N2 and avian H3N8. Intramolecular contacts were determined between the protein backbone and glycosite glycan based on available three-dimensional structure data. We found that glycosite "N165" (H3 numbering) is occupied by high-mannose glycans in H3 HA but by complex glycans in all LPAIV HAs. SP-D was not active on LPAIV but was on H3 HAs. Since SP-D affinity for influenza HA depends on the presence of high-mannose glycan on the head region, our data demonstrate that SP-D may not protect against virus containing these HA subtypes. Our results also demonstrate that glycan subtype can be predicted at some glycosites based on sequence comparisons and three-dimensional structural analysis.IMPORTANCE Low-pathogenicity avian influenza virus (LPAIV) subtypes can reassort with circulating human strains and pandemic viruses can emerge in human populations, as was seen in the 1957 pandemic, in which an H2 virus reassorted with the circulating H1N1 to create a novel H2N2 genotype. Lung surfactant protein D (SP-D), a key factor in first-line innate immunity defense, removes influenza type A virus (IAV) through interaction with hemagglutinin (HA) head region high-mannose glycan(s). While it is known that both H1 and H3 HAs have one or more key high-mannose glycosites in the head region, little is known about similar glycosylation of LPAIV strains H2N1, H5N1, H6N1, or H11N9, which may pose future health risks. Here, we demonstrate that the hemagglutinins of LPAIV strains do not have the required high-mannose glycans and do not interact with SP-D, and that sequence analysis can predict glycan subtype, thus predicting the presence or absence of this virulence marker.

Link(s):

https://dx.doi.org/10.1128/JVI.01951-19

12.

Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/2017 and 2017/2018 in Poland.

Author(s): Hallmann-Szelinska, E; Luniewska, K; Szymanski, K; Kowalczyk, D; Salamatin, R; Masny, A; Brydak, L B

Source: Adv Exp Med Biol;1251: 107-113, 2020.

MEDLINE - International Database for Medical Literature PMID: 31832902

Abstract: The World Health Organization estimates that influenza virus infects 3-5 million people worldwide every year, of whom 290,000 to 650,000 die. In the 2016/2017 epidemic season in Poland, the incidence of influenza was 1,692 per 100,000 population. The influenza A virus, subtype A/H3N2/, was the predominant one in that season. However, in the most recent 2017/2018 epidemic season, the incidence exceeded 1,782 per 100,000 already by August of 2018. In this season, influenza B virus predominate (more)

Link(s):

https://dx.doi.org/10.1007/5584_2019_454

Results 1-12 de 10.948

<< First < Previous 01 02 03 04 05 06 07 08 09 10 Next >

Search | Influenza A(H1N1)

Search history ()

Your selection ()

Refine your search

Send by email

Serum expression of microRNA-16 in a cohort of Egyptian patients with ulcerative colitis and its correlation with disease extent and severity/ Expressão sérica do microRNA-16 em uma coorte de pacientes egípcios com colite ulcerosa e sua correlação com a extensão e gravidade da doença

Consumo alimentar de pacientes renais crônicos submetidos à diálise peritoneal e fatores associados/ Food intake by chronic kidney patients undergoing peritoneal dialysis and associated factors

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Dendritic Cells Targeting Lactobacillus plantarum Strain NC8 with a Surface-Displayed Single-Chain Variable Fragment of CD11c Induce an Antigen-Specific Protective Cellular Immune Response.

Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase.

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans.

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.

Influenza Virus Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: N-Glycan Subtypes in Host-Pathogen Interactions.

Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/2017 and 2017/2018 in Poland.

Search | Influenza A(H1N1)

Options