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Pesquisa | Influenza A (H1N1)

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Resultados  1-12 de 8.990

Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.

Autor(es): Yuan, Yukang; Miao, Ying; Zeng, Chenhua; Liu, Jin; Chen, Xiangjie; Qian, Liping; Wang, Xiaofang; Qian, Feng; Yu, Zhengyuan; Wang, Jun; Qian, Guanghui; Fu, Qian; Lv, Haitao; Zheng, Hui
Fonte: Immunology;159(3): 309-321, 2020 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31691271
Resumo: Type-I interferons (IFN-I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the antiviral efficacy of IFN-I is largely restricted by negative regulators of IFN-I signaling in cells. Therefore, identification of intracellular inhibitors of IFN-I signaling is important for developing novel targets to improve IFN-I antiviral therapy. In this study, we report that the deubiquitinase ubiquitin-specific protease 7 (USP7) negatively regulates IFN-I-mediated anti (mais)

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Autor(es): Russier, Marion; Yang, Guohua; Briard, Benoit; Meliopoulos, Victoria; Cherry, Sean; Kanneganti, Thirumala-Devi; Schultz-Cherry, Stacey; Vogel, Peter; Russell, Charles J
Fonte: J Virol;94(3)2020 Jan 17.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31694942
Resumo: Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) virus (activation pH, 5.5). The extracellular lung pH was measured to be near neutral ( (mais)

Antiviral Activity of Fritillaria thunbergii Extract against Human Influenza Virus H1N1 (PR8) In Vitro, In Ovo and In Vivo.

Autor(es): Kim, Minjee; Nguyen, Dinh-Van; Heo, Yoonki; Park, Ki Hoon; Paik, Hyun-Dong; Kim, Young Bong
Fonte: J Microbiol Biotechnol;30(2): 172-177, 2020 Feb 28.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31752057
Resumo: Influenza viruses cause respiratory diseases in humans and animals with high morbidity and mortality rates. Conventional anti-influenza drugs are reported to exert side effects and newly emerging viral strains tend to develop resistance to these commonly used agents. Fritillaria thunbergii (FT) is traditionally used as an expectorant for controlling airway inflammatory disorders. Here, we evaluated the therapeutic effects of FT extracts against influenza virus type A (H1N1) infection in vit (mais)

Source of oseltamivir resistance due to single E119D and double E119D/H274Y mutations in pdm09H1N1 influenza neuraminidase.

Autor(es): Hanpaibool, Chonnikan; Leelawiwat, Matina; Takahashi, Kaito; Rungrotmongkol, Thanyada
Fonte: J Comput Aided Mol Des;34(1): 27-37, 2020 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31773463
Resumo: Influenza epidemics are responsible for an average of 3-5 millions of severe cases and up to 500,000 deaths around the world. One of flu pandemic types is influenza A(H1N1)pdm09 virus (pdm09H1N1). Oseltamivir is the antiviral drug used to treat influenza targeting at neuraminidase (NA) located on the viral surface. Influenza virus undergoes high mutation rates and leads to drug resistance, and thus the development of more efficient drugs is required. In the present study, all-atom molecular (mais)

Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264.7 cells.

Autor(es): Tian, Jing; Qu, Na; Jiao, Xue; Wang, Xiaonan; Geng, Jin; Griffin, Noreen; Shan, Fengping
Fonte: Int Immunopharmacol;78: 106032, 2020 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31835089
Resumo: MENK, as an immune adjuvant, has potential immune-regulatory activity on innate and adaptive immune cells. The aim of this work was to investigate the antiviral effect of MENK on influenza virus-infected murine macrophage cells (RAW264.7) and its underlying mechanisms. The results showed that MENK markedly inhibited influenza A virus (H1N1) replication in pre- and post-MENK treatment, especially in pre-MENK treatment. The mechanisms exploration revealed that MENK (10 mg/mL) significant (mais)

Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis.

Autor(es): Berkebile, Abigail R; Bartlett, Jennifer A; Abou Alaiwa, Mahmoud; Varga, Steven M; Power, Ultan F; McCray, Paul B
Fonte: Am J Respir Cell Mol Biol;62(1): 104-111, 2020 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31242392
Resumo: Although chronic bacterial infections and inflammation are associated with progressive lung disease in patients with cystic fibrosis (CF), much less is known regarding the contributions of respiratory viral infections to this process. Clinical studies suggest that antiviral host defenses may be compromised in individuals with CF, and CF airway epithelia exhibit impaired antiviral responses in vitro. Here, we used the CF pig model to test the hypothesis that the antiviral activity of respira (mais)

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.

Autor(es): Venkatesan, Sudhir; Myles, Puja R; Bolton, Kirsty J; Muthuri, Stella G; Al Khuwaitir, Tarig; Anovadiya, Ashish P; Azziz-Baumgartner, Eduardo; Bajjou, Tahar; Bassetti, Matteo; Beovic, Bojana; Bertisch, Barbara; Bonmarin, Isabelle; Booy, Robert; Borja-Aburto, Victor H; Burgmann, Heinz; Cao, Bin; Carratala, Jordi; Chinbayar, Tserendorj; Cilloniz, Catia; Denholm, Justin T; Dominguez, Samuel R; Duarte, Pericles A D; Dubnov-Raz, Gal; Fanella, Sergio; Gao, Zhancheng; Gérardin, Patrick; Giannella, Maddalena; Gubbels, Sophie; Herberg, Jethro; Higuera Iglesias, Anjarath Lorena; Hoeger, Peter H; Hu, Xiao Yun; Islam, Quazi T; Jiménez, Mirela F; Keijzers, Gerben; Khalili, Hossein; Kusznierz, Gabriela; Kuzman, Ilija; Langenegger, Eduard; Lankarani, Kamran B; Leo, Yee-Sin; Libster, Romina P; Linko, Rita; Madanat, Faris; Maltezos, Efstratios; Mamun, Abdullah; Manabe, Toshie; Metan, Gokhan; Mickiene, Aukse; Mikic, Dragan
Fonte: J Infect Dis;221(3): 356-366, 2020 Jan 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31314899
Resumo: BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid t (mais)

Polygalasaponin F treats mice with pneumonia induced by influenza virus.

Autor(es): Ye, Yi; Wang, Huixian; Liu, Jinyuan; Zhao, Fang; Xu, Peiping
Fonte: Inflammopharmacology;28(1): 299-310, 2020 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31446589
Resumo: BACKGROUND: Influenza is an acute viral respiratory illness that causes high morbidity and mortality globally. Therapeutic actions are limited to vaccines and a few anti-viral drugs. Polygala (P.) japonica herba is rich in Polygalasaponin F (PSF, C53H86O23), used for acute bronchitis, pharyngitis, pneumonia, amygdalitis, and respiratory tract infections treatment in China. Hypercytokinemia is often correlated with severe pneumonia caused by several influenza viruses. PSF was reported to hav (mais)

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.

Autor(es): Ilyushina, Natalia A; Komatsu, Takashi E; Ince, William L; Donaldson, Eric F; Lee, Nicolette; O'Rear, Julian J; Donnelly, Raymond P
Fonte: Virol J;16(1): 149, 2019 11 29.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31783761
Resumo: BACKGROUND: Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the influenza hemagglutinin (HA) protein. Numerous HA substitutions have been identified in nonclinical NAI resistance-selection experiments as well as in clinical specimens from NAI treatment or surveillance studies. These mutations are listed in th (mais)

Antiviral activity of amides and carboxamides of quinolizidine alkaloid (-)-cytisine against human influenza virus A (H1N1) and parainfluenza virus type 3.

Autor(es): Fedorova, Victoria A; Kadyrova, Renata A; Slita, Alexander V; Muryleva, Anna A; Petrova, Polina R; Kovalskaya, Alena V; Lobov, Alexander N; Zileeva, Zulfiya R; Tsypyshev, Dmiry O; Borisevich, Sophia S; Tsypysheva, Inna P; Vakhitova, Julia V; Zarubaev, Vladimir V
Fonte: Nat Prod Res;: 1-9, 2019 Dec 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31790286
Resumo: Novel derivatives of quinolizidine alkaloid (-)-cytisine were synthesised. ADME properties, cytotoxicity against HEK293 cells and activity against viruses of influenza A/California/07/09(H1N1)pdm09 virus (IAV) and human parainfluenza virus type 3 (HPIV3) were evaluated. It was shown, that 9-carboxamides of methylcytisine (with phenyl and allyl urea's fragments) are most active compounds against IAV probably due to predicted in silico peculiarity of their interactions with the 4R7B active si (mais)

Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos.

Autor(es): Mehrbod, Parvaneh; Ebrahimi, Samad Nejad; Fotouhi, Fatemeh; Eskandari, Fatemeh; Eloff, Jacobus N; McGaw, Lyndy J; Fasina, Folorunso O
Fonte: BMC Complement Altern Med;19(1): 346, 2019 Dec 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31791311
Resumo: BACKGROUND: Influenza A virus (IAV) is still a major health threat. The clinical manifestations of this infection are related to immune dysregulation, which causes morbidity and mortality. The usage of traditional medication with immunomodulatory properties against influenza infection has been increased recently. Our previous study showed antiviral activity of quercetin-3-O-α-L-rhamnopyranoside (Q3R) isolated from Rapanea melanophloeos (RM) (L.) Mez (family Myrsinaceae) against H1N1 (A (mais)

Antiviral activities of extremophilic actinomycetes extracts from Kazakhstan's unique ecosystems against influenza viruses and paramyxoviruses.

Autor(es): Berezin, Vladimir; Abdukhakimova, Diyora; Trenozhnikova, Lyudmila; Bogoyavlenskiy, Andrey; Turmagambetova, Aizhan; Issanov, Alpamys; Azizan, Azliyati
Fonte: Virol J;16(1): 150, 2019 12 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31791359
Resumo: BACKGROUND: Commercially available antiviral drugs, when used in the treatment of viral infections, do not always result in success. This is an urgent problem currently that needs to be addressed because several viruses including influenza and paramyxoviruses are acquiring multi-drug resistance. A potential solution for this emerging issue is to create new antiviral drugs from available compounds of natural products. It is known that the majority of drugs have been developed using compounds (mais)
Resultados  1-12 de 8.990