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Resultados  1-12 de 8.503

Descripción de características demográficas y clínicas de una cohorte pacientes fallecidos por infección respiratoria aguda en Colombia durante los años 2009 a 2013/ Description of demographic and clinical characteristics of a cohort of patients with mortality due to acute respiratory infection in Colombia during the years 2009 to 2013

Autor(es): Amaya Santiago, Héctor Julio; Barbosa, Juliana; Saavedra Trujillo, Carlos Humberto
Fonte: Infectio;23(2): 143-147, Apr.-June 2019. tab, graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 989945  LILACS Express
Resumo: Resumen Objetivo: Describir las características clínicas, demográficas, aislamientos virales y hallazgos de histopatología de individuos que fallecieron por Infección Respiratoria Aguda (IRA) y que fueron notificados al Instituto Nacional de Salud (INS) entre los años 2009 y 2013. Métodos: Estudio observacional, descriptivo, retrospectivo, basado en la revisión de fichas epidemiológicas y reportes de estudios de virología e histopatología de muestras respiratorias de individu (mais)

Infección respiratoria por adenovirus en pediatría: de ayer a hoy/ Adenovirus pediatric respiratory infection: past and present

Autor(es): Avendaño C, Luis F
Fonte: Neumol. pediátr. (En línea);14(1): 12-18, abr. 2019. ilus, tab
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 995613
Resumo: Acute respiratory infections represent a world pediatric health burden. RSV, influenza and adenoviruses are among the most frequent causative agents. Adenoviruses usually produce upper respiratory infections, but they can be responsible for acute lower respiratory infection in children with severe clinical outcome. It is necessary a special clinical and epidemiological organization to avoid nosocomial adenovirus local outbreaks. Rapid diagnose, done by immunofluorescence assay and PCR, indi (mais)

Influenza A. Manejo ambulatorio/ Influenza A. Ambulatory management

Autor(es): Nogales, José Alejandro
Fonte: Rev. Asoc. Méd. Argent;132(1): 28-32, Mar. 2019. tab, graf
LILACS - Literatura Latino-Americana e do Caribe em Ciências da Saúde ID: 1010018
Resumo: Introducción. La influenza A constituye uno de los principales problemas de salud que enfrenta la humanidad.El manejo clínico ambulatorio usando el protocolo de oseltamivir y saturomería permite realizar una práctica evaluación. Objetivo. Evaluar resultados usando protocolo de oseltamivir y saturometría en atención médica ambulatoria y emergencias en pacientes con influenza A. Métodos. Realizar un estudio clínico experimental aleatorio en pacientes con influenza A, usando protocol (mais)

In vitro and in vivo characterization of novel neuraminidase substitutions in influenza A(H1N1)pdm09 identified using Laninamivir-mediated selection.

Autor(es): Lloren, Khristine Kaith S; Kwon, Jin Jung; Choi, Won-Suk; Jeong, Ju Hwan; Jeong Ahn, Su; Ki Choi, Young; Baek, Yun Hee; Song, Min-Suk
Fonte: J Virol;2019 Jan 02.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30602610
Resumo: Neuraminidase inhibitors (NAIs) are widely used antiviral drugs for the treatment of humans with influenza virus infections. There have been widespread reports of NAI resistance among seasonal A(H1N1) viruses, and most have been identified in oseltamivir-exposed patients or those treated with other NAIs. Thus, monitoring and identifying NA markers conferring resistance to NAIs-particularly newly introduced treatments-is critical to manage viral infections. Therefore, we screened and identif (mais)

Respiratory Pathogens in Infants Diagnosed with Acute Lower Respiratory Tract Infection in a Tertiary Care Hospital of Western India Using Multiplex Real Time PCR.

Autor(es): Sonawane, Anuja A; Shastri, Jayanthi; Bavdekar, Sandeep B
Fonte: Indian J Pediatr;2019 Jan 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30637585
Resumo: OBJECTIVE: To determine the frequency of respiratory pathogens in infants diagnosed with acute lower respiratory tract infections. METHODS: A prospective cross-sectional observational study was conducted in infants hospitalized with a diagnosis of acute lower respiratory tract infection (ALRTI), in a tertiary care hospital in a metropolitan city of Western India. Nasopharyngeal swabs were analyzed by multiplex real time polymerase chain reaction, for 18 viruses and 3 bacteria (H. influenzae (mais)

Predictors of Fatality in Influenza A Virus Subtypes Infection among inpatients in 2015-2016 season.

Autor(es): Tekin, S; Keske, S; Alan, S; Batirel, A; Karakoc, C; Tasdelen-Fisgin, N; Simsek-Yavuz, S; Isler, B; Aydin, M; Kapmaz, M; Yilmaz-Karadag, F; Ergonul, O
Fonte: Int J Infect Dis;2019 Jan 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30641199
Resumo: BACKGROUND: Influenza A infection could cause to severe disease and mortality. The effect of different subtypes of Influenza on morbidity and mortality is not known yet in Turkey OBJECTIVES: We aimed to describe the predictors for fatality related to influenza A infection among hospitalized patients in Istanbul in 2015-2016 influenza season, and to detail the differences between H3N2 and H1N1. STUDY DESIGN: This is a multicenter study performed by Istanbul respiratory infections study group (mais)

Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin.

Autor(es): Superti, Fabiana; Agamennone, Mariangela; Pietrantoni, Agostina; Ammendolia, Maria Grazia
Fonte: Viruses;11(1)2019 Jan 11.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30641890
Resumo: Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities. Recently, we have shown that bLf, and in particular its C-lobe, interacts with influenza A virus hemagglutinin and prevents infection by different H1 and H3 viral subtypes. Influenza virus hemagglutinin (HA), and in particular its highly conserved fusion peptide involved in the low-pH-mediated fusion process, plays a sign (mais)

miR-193b represses influenza A virus infection by inhibiting Wnt/ß-catenin signaling.

Autor(es): Yang, Xiaoyun; Zhao, Chunling; Bamunuarachchi, Gayan; Wang, Yang; Liang, Yurong; Huang, Chaoqun; Zhu, Zhengyu; Xu, Dao; Lin, Kong; Senavirathna, Lakmini Kumari; Xu, Lan; Liu, Lin
Fonte: Cell Microbiol;: e13001, 2019 Jan 16.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30650225
Resumo: Due to an increasing emergence of new and drug-resistant strains of the influenza A virus (IAV), developing novel measures to combat influenza is necessary. We have previously shown that inhibiting Wnt/ß-catenin pathway reduces IAV infection. In this study, we aimed to identify antiviral human microRNAs (miRNAs) that target the Wnt/ß-catenin signaling pathway. Using a miRNA expression library, we identified 85 miRNAs that upregulated and 20 miRNAs that downregulated the Wnt/ß-catenin sig (mais)

Pediatric influenza and illness severity: what is known and what questions remain?

Autor(es): Doyle, Joshua D; Campbell, Angela P
Fonte: Curr Opin Pediatr;31(1): 119-126, 2019 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30531402
Resumo: PURPOSE OF REVIEW: Influenza causes a range of illnesses in children, from uncomplicated self-limited illness to severe disease and death. This review provides an update on the severity and burden of influenza in US children over recent seasons. RECENT FINDINGS: The 2017-2018 influenza season was widespread and severe across all ages, including children. Disease severity is influenced by influenza virologic characteristics and host factors, as well as public health interventions such as inf (mais)

Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.

Autor(es): Li, Haiwei; Li, Man; Xu, Renyang; Wang, Shouxin; Zhang, Yongmin; Zhang, Lihe; Zhou, Demin; Xiao, Sulong
Fonte: Eur J Med Chem;163: 560-568, 2019 Feb 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30554131
Resumo: It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 ( (mais)

Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.

Autor(es): Hong, Bei-Tao; Cheng, Yih-Shyun E; Cheng, Ting-Jen; Fang, Jim-Min
Fonte: Eur J Med Chem;163: 710-721, 2019 Feb 01.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30576902
Resumo: Tamiflu readily undergoes endogenous hydrolysis to give oseltamivir carboxylic acid (OC) as the active anti-influenza agent to inhibit the viral neuraminidase (NA). GOC is derived from OC by replacing the 5-amino group with a guanidino group. In this study, OC and GOC congeners with the carboxylic acid bioisosteres of boronic acid, trifluoroborate, sulfone, sulfinic acid, sulfonic acid and sulfonate ester were first synthesized, starting with conversion of OC to a Barton ester, followed by (mais)

A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9.

Autor(es): Li, Zhanping; Wan, Zhimin; Li, Tuofan; Xie, Quan; Sun, Haiwei; Chen, Hongjun; Liang, Guangchen; Shao, Hongxia; Qin, Aijian; Ye, Jianqiang
Fonte: Vet Microbiol;228: 39-44, 2019 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 30593378
Resumo: In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus (IAV). These mAbs could react with HA of H7N9, H3N2, and H9N2 with neutralizing activity. A novel linear epitope recognized by these mAbs was identified by peptide-based ELISA, and this epitope was located in TAADYKSTQSAIDQITGKLN at the C terminus of the helix A of H7N9. 3 A11, which is one of (mais)
Resultados  1-12 de 8.503