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Resultados  1-12 de 10.822

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Autor(es): Ivan, Fransiskus X; Zhou, Xinrui; Lau, Suk Hiang; Rashid, Shamima; Teo, Jasmine S M; Lee, Hong Kai; Koay, Evelyn S; Chan, Kwai Peng; Leo, Yee Sin; Chen, Mark I C; Kwoh, Chee Keong; Chow, Vincent T
Fonte: Int J Infect Dis;90: 84-96, 2020 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31669593
Resumo: BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. METHODS: The complete genomes of influenza A/H1N1, A/H3N2 and B viruses that caused mild infections among outpatients and severe infections among inpatients in Singapore during 2012-2015 were sequenced and characterized. Using various bioinfo (mais)

Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.

Autor(es): Yuan, Yukang; Miao, Ying; Zeng, Chenhua; Liu, Jin; Chen, Xiangjie; Qian, Liping; Wang, Xiaofang; Qian, Feng; Yu, Zhengyuan; Wang, Jun; Qian, Guanghui; Fu, Qian; Lv, Haitao; Zheng, Hui
Fonte: Immunology;159(3): 309-321, 2020 03.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31691271
Resumo: Type-I interferons (IFN-I) are used as common antiviral drugs for a range of viral diseases in clinic. However, the antiviral efficacy of IFN-I is largely restricted by negative regulators of IFN-I signaling in cells. Therefore, identification of intracellular inhibitors of IFN-I signaling is important for developing novel targets to improve IFN-I antiviral therapy. In this study, we report that the deubiquitinase ubiquitin-specific protease 7 (USP7) negatively regulates IFN-I-mediated anti (mais)

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Autor(es): Russier, Marion; Yang, Guohua; Briard, Benoit; Meliopoulos, Victoria; Cherry, Sean; Kanneganti, Thirumala-Devi; Schultz-Cherry, Stacey; Vogel, Peter; Russell, Charles J
Fonte: J Virol;94(3)2020 Jan 17.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31694942
Resumo: Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) virus (activation pH, 5.5). The extracellular lung pH was measured to be near neutral ( (mais)

Dendritic Cells Targeting Lactobacillus plantarum Strain NC8 with a Surface-Displayed Single-Chain Variable Fragment of CD11c Induce an Antigen-Specific Protective Cellular Immune Response.

Autor(es): Liu, Jing; Yang, Guilian; Huang, Haibin; Shi, Chunwei; Gao, Xing; Yang, Wentao; Zhang, Zan; Liu, Yang; Xu, Ke; Wang, Jianzhong; Kang, Yuanhuan; Jiang, Yanlong; Wang, Chunfeng
Fonte: Infect Immun;88(2)2020 01 22.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31740528
Resumo: Influenza A virus (H1N1) is an acute, highly contagious respiratory virus. The use of lactic acid bacteria (LAB) to deliver mucosal vaccines against influenza virus infection is a research hot spot. In this study, two recombinant Lactobacillus plantarum strains expressing hemagglutinin (HA) alone or coexpressing aCD11c-HA to target HA protein to dendritic cells (DCs) by fusion to an anti-CD11c single-chain antibody (aCD11c) were constructed. The activation of bone marrow dendritic cells (BM (mais)

Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase.

Autor(es): Evseenko, Vasily A; Svyatchenko, Svetlana V; Kolosova, Natalia P; Kovrizhkina, Valentina L; Marchenko, Vasiliy Y; Durymanov, Aleksander G; Goncharova, Natalia I; Ryzhikov, Alexander B
Fonte: Arch Virol;165(1): 201-206, 2020 Jan.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31745716
Resumo: Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT50) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT50 was observed with the seasonal human H3N2 virus (45.5 °C). The IT50 values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon I (mais)

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans.

Autor(es): Rijal, Pramila; Wang, Bei Bei; Tan, Tiong Kit; Schimanski, Lisa; Janesch, Philipp; Dong, Tao; McCauley, John W; Daniels, Rodney S; Townsend, Alain R; Huang, Kuan-Ying A
Fonte: J Virol;94(4)2020 Jan 31.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31748388
Resumo: The majority of antibodies induced by influenza neuraminidase (NA), like those against hemagglutinin (HA), are relatively specific to viruses isolated within a limited time window, as seen in serological studies and the analysis of many murine monoclonal antibodies (MAbs). We report three broadly reactive human MAbs targeting N1 NA. Two were isolated from a young adult vaccinated with trivalent influenza vaccine (TIV), which inhibited N1 NA from viruses isolated from humans over a period of (mais)

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Autor(es): Smith, Andrew; Rodriguez, Laura; El Ghouayel, Maya; Nogales, Aitor; Chamberlain, Jeffrey M; Sortino, Katherine; Reilly, Emma; Feng, Changyong; Topham, David J; Martínez-Sobrido, Luis; Dewhurst, Stephen
Fonte: J Virol;94(4)2020 Jan 31.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31748399
Resumo: Influenza A virus (IAV) causes significant morbidity and mortality, despite the availability of viral vaccines. The efficacy of live attenuated influenza vaccines (LAIVs) has been especially poor in recent years. One potential reason is that the master donor virus (MDV), on which all LAIVs are based, contains either the internal genes of the 1960 A/Ann Arbor/6/60 or the 1957 A/Leningrad/17/57 H2N2 viruses (i.e., they diverge considerably from currently circulating strains). We previously sh (mais)

Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.

Autor(es): Rodriguez-Frandsen, Ariel; Martin-Sancho, Laura; Gounder, Anshu P; Chang, Max W; Liu, Wen-Chun; De Jesus, Paul D; von Recum-Knepper, Jessica; Dutra, Miriam S; Huffmaster, Nicholas J; Chavarria, Monica; Mena, Ignacio; Riva, Laura; Nguyen, Courtney B; Dobariya, Saunil; Herbert, Kristina M; Benner, Christopher; Albrecht, Randy A; García-Sastre, Adolfo; Chanda, Sumit K
Fonte: J Virol;94(4)2020 Jan 31.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31776276
Resumo: Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, as well as sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different species is, in part, dictated by its ability to exploit the genetic environment of the host cell. To investigate IAV tropism in human cells, we evaluated the replication of IAV strains in a diverse subset of epithelial cell lines. HeLa cells were refractory to the growth of human H1 (mais)

Influenza Virus Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: N-Glycan Subtypes in Host-Pathogen Interactions.

Autor(es): Parsons, Lisa M; An, Yanming; Qi, Li; White, Mitchell R; van der Woude, Roosmarijn; Hartshorn, Kevan L; Taubenberger, Jeffery K; de Vries, Robert P; Cipollo, John F
Fonte: J Virol;94(5)2020 Feb 14.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31826991
Resumo: Seasonal influenza carrying key hemagglutinin (HA) head region glycosylation sites can be removed from the lung by pulmonary surfactant protein D (SP-D). Little is known about HA head glycosylation of low-pathogenicity avian influenza virus (LPAIV) subtypes. These can pose a pandemic threat through reassortment and emergence in human populations. Since the presence of head region high-mannose glycosites dictates SP-D activity, the ability to predict these glycosite glycan subtypes may be of (mais)

Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/2017 and 2017/2018 in Poland.

Autor(es): Hallmann-Szelinska, E; Luniewska, K; Szymanski, K; Kowalczyk, D; Salamatin, R; Masny, A; Brydak, L B
Fonte: Adv Exp Med Biol;1251: 107-113, 2020.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31832902
Resumo: The World Health Organization estimates that influenza virus infects 3-5 million people worldwide every year, of whom 290,000 to 650,000 die. In the 2016/2017 epidemic season in Poland, the incidence of influenza was 1,692 per 100,000 population. The influenza A virus, subtype A/H3N2/, was the predominant one in that season. However, in the most recent 2017/2018 epidemic season, the incidence exceeded 1,782 per 100,000 already by August of 2018. In this season, influenza B virus predominate (mais)

Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults.

Autor(es): LeBlanc, J J; ElSherif, M; Mulpuru, S; Warhuus, M; Ambrose, A; Andrew, M; Boivin, G; Bowie, W; Chit, A; Dos Santos, G; Green, K; Halperin, S A; Hatchette, T F; Ibarguchi, B; Johnstone, J; Katz, K; Langley, J M; Lagacé-Wiens, P; Loeb, M; Lund, A; MacKinnon-Cameron, D; McCarthy, A; McElhaney, J E; McGeer, A; Poirier, A; Powis, J; Richardson, D; Semret, M; Shinde, V; Smyth, D; Trottier, S; Valiquette, L; Webster, D; Ye, L; McNeil, S A
Fonte: J Med Microbiol;69(2): 256-264, 2020 Feb.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31264957
Resumo: Background. The Serious Outcomes Surveillance Network of the Canadian Immunization Research Network (CIRN SOS) has been performing active influenza surveillance since 2009 ( identifier: NCT01517191). Influenza A and B viruses are identified and characterized using real-time reverse-transcriptase polymerase chain reaction (RT-PCR), and multiplex testing has been performed on a subset of patients to identify other respiratory virus aetiologies. Since both methods can identif (mais)

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.

Autor(es): Ilyushina, Natalia A; Komatsu, Takashi E; Ince, William L; Donaldson, Eric F; Lee, Nicolette; O'Rear, Julian J; Donnelly, Raymond P
Fonte: Virol J;16(1): 149, 2019 11 29.
MEDLINE - Literatura Internacional em Ciências da Saúde PMID: 31783761
Resumo: BACKGROUND: Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the influenza hemagglutinin (HA) protein. Numerous HA substitutions have been identified in nonclinical NAI resistance-selection experiments as well as in clinical specimens from NAI treatment or surveillance studies. These mutations are listed in th (mais)
Resultados  1-12 de 10.822