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3.
Article in English | MEDLINE | ID: mdl-25566896

ABSTRACT

Allopurinol, a drug commonly used for treating gout and hyperuricemia, is a frequent cause of drug eruptions. Recent investigations suggest that HLA-BFNx015801 allele is a very strong marker for allopurinol-induced cutaneous adverse drug reactions (cADRs). In this article we report two cases of allopurinol-induced drug eruptions in patients carrying the HLA-BFNx015801 allele and review the literature on the association between HLA-BFNx015801 and allopurinol-induced cADRs based on a MEDLINE and PubMed search.


Subject(s)
Allopurinol/adverse effects , Drug Eruptions/etiology , Gout Suppressants/adverse effects , HLA-B Antigens/genetics , Aged , Alleles , Drug Eruptions/genetics , Humans , Male , Middle Aged
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