ABSTRACT
Bacille Calmette-Guerin (BCG) vaccine is administered worldwide to neonates and considered safe. Serious complications like disseminated BCGosis are extremely rare occurrences (<1 per million vaccinations). A 6 months male was brought to paediatric outpatient department with fever and swelling over the dorsum of the left hand for 5 days. On examination, he was febrile and had hepatosplenomegaly. X-ray of the hand showed lytic lesions in the first and second metacarpals. Provisional clinical diagnosis included Langerhans cell histiocytosis, congenital syphilis, and haematological malignancy. Fine Needle Aspiration Cytology (FNAC) was done from the swelling and showed diffuse sheets of histiocytes with both intracellular and extracellular rod-shaped unstained structures along with inflammatory cells. These ghost images stained positive with ZN stain. A cytological diagnosis of atypical mycobacteria vs leprosy was made. Child was revisited and found to have an active BCG scar. Further investigations showed low serum IgM and positive AFB culture. These bacilli were confirmed by GenoType MTBDR plus test as Mycobacterium bovis. Despite Antitubercular therapy, the patient succumbed to death. This case highlights the variable clinical presentation of BCGosis. Its occurrence may unmask any underlying immunodeficiency. If unfamiliar with the above cytological features and in absence of routinely performed special stains, the cytopathologist may miss these notorious organisms and treat such cases like suppurative lesions. To conclude, an early and definitive diagnosis of BCGosis can be established on FNAC which would ensure timely management and better outcome in this highly lethal entity.
Subject(s)
Antitubercular Agents/administration & dosage , BCG Vaccine/adverse effects , Mycobacterium bovis , Tuberculosis , Cytodiagnosis , Fatal Outcome , Humans , Infant , Male , Tuberculosis/diagnosis , Tuberculosis/drug therapyABSTRACT
Lepromatous leprosy (LL) has been reported in the literature with Non Hodgkin Lymphoma and rarely with Hodgkin Lymphoma. However, an extensive search of the literature shows no case report describing anaplastic large cell lymphoma (ALCL) in association with LL. We report a case of a young male with LL who was found to have ALCL. This is an interesting case of coexistence of an endemic infectious disease and a rare lymphoma involving the same lymph node, with a brief review of the literature.
Subject(s)
Leprosy, Lepromatous/complications , Lymph Nodes/pathology , Lymphoma, Large-Cell, Anaplastic/complications , Adult , Cell Nucleus Shape , Clofazimine/administration & dosage , Clofazimine/therapeutic use , Histiocytes/chemistry , Histiocytes/pathology , Humans , Immunohistochemistry , Ki-1 Antigen/chemistry , Leprosy, Lepromatous/drug therapy , Lymphoma, Large-Cell, Anaplastic/drug therapy , Lymphoma, Large-Cell, Anaplastic/microbiology , Male , Mycobacterium leprae/isolation & purification , Mycobacterium leprae/pathogenicity , Pancytopenia/drug therapy , Pancytopenia/pathology , Rifampin/administration & dosage , Rifampin/therapeutic use , Skin Diseases, Bacterial/microbiology , Skin Diseases, Bacterial/pathologyABSTRACT
We report a case of a 58-year-old female patient who presented with multiple, asymptomatic, slowly-growing, raised pigmented lesions all over her body for the past 10 years with ulceration in one of the lesions on the trunk for the past five months. Histopathology of the lesion revealed features consistent with melanoacanthoma. Here, we report the first case of cutaneous melanoacanthoma presenting with an ulcerated plaque and the third case of cutaneous melanoacanthoma with multiple lesions. To the best of our knowledge, ulceration has not yet been reported as a feature of cutaneous melanoacanthoma in the medical literature.