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Chronic mucocutaneous candidiasis with deficient CD2 (E receptor) but normal CD3 mononuclear cells.

Noh, L M; Hussein, S H; Sukumaran, K D; Rose, I; Abdullah, N.

J Clin Lab Immunol ; 35(2): 89-93, 1991 Jun.

Article in English | MEDLINE | ID: mdl-1688166

ABSTRACT

A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.

Subject(s)

Antigens, Differentiation, T-Lymphocyte , CD3 Complex/analysis , Candidiasis, Chronic Mucocutaneous/complications , Candidiasis, Oral/complications , Immunologic Deficiency Syndromes/complications , Opportunistic Infections/complications , Receptors, Immunologic , T-Lymphocyte Subsets/immunology , Antigens, Differentiation, T-Lymphocyte/genetics , CD2 Antigens , Candidiasis, Chronic Mucocutaneous/immunology , Candidiasis, Oral/immunology , Disease Susceptibility/immunology , Female , Genetic Predisposition to Disease , Humans , Immunocompromised Host , Immunologic Deficiency Syndromes/genetics , Immunologic Deficiency Syndromes/immunology , Infant , Lymphocyte Activation , Opportunistic Infections/immunology , Receptors, Immunologic/genetics , Toxoplasmosis/complications , Toxoplasmosis/immunology , Tuberculosis/complications , Tuberculosis/immunology

ABSTRACT

Subject(s)

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