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Immunol Invest ; 49(3): 333-363, 2020 Apr.
Article in English | MEDLINE | ID: mdl-31648579

ABSTRACT

In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From the study, it is found that global diseases, like Crohn's disease, rheumatoid arthritis, Graves' disease, gelatin allergy, T1D, HIV, systemic lupus erythematosus, juvenile chronic arthritis, and Mycobacterial disease (tuberculosis and leprosy) suspected associated with the Indonesian HLA profiles.


Subject(s)
Disease/genetics , Genetic Predisposition to Disease/genetics , HLA Antigens/genetics , Alleles , Gene Frequency , Genetic Association Studies , Genetic Predisposition to Disease/epidemiology , Genetic Variation , Humans , Indonesia/epidemiology , Prevalence
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