Subject(s)
Alopecia/diagnosis , Alopecia/pathology , Skin/pathology , Alopecia/complications , Biopsy , Dermoscopy , Eyebrows , Facial Dermatoses/etiology , Female , Fibrosis , Forehead , Hair/diagnostic imaging , Humans , Hyperpigmentation/etiology , Hypopigmentation/complications , Lichen Planus/complications , ScalpABSTRACT
BACKGROUND: Melasma is a common acquired hyperpigmentary disorder of the sun exposed skin, especially the face. The pathogenesis is unclear but interplay between genetic factors, hormones and ultraviolet radiation is important. We have evaluated the histological characteristics of melasma and compared the findings with adjacent normal skin. METHODS: Skin biopsies were taken from both melasma and the surrounding perilesional normal skin in 50 Indian women. The sections were stained with hematoxylin and eosin, Fontana-Masson and Verhoeff-Van Gieson stains. RESULTS: Biopsy from melasma showed significant epidermal atrophy, basal cell hyperpigmentation and solar elastosis when compared with the perilesional skin. We found that the proportion of pendulous melanocytes was significantly higher in the lesional biopsy compared with the perilesional biopsy (76% vs 42%, P < 0.001). Similarly, pigmentary incontinence and features of solar elastosis were significantly higher in the lesional skin compared with the perilesional skin. CONCLUSION: The characteristic histopathological features such as epidermal atrophy, basal cell hyperpigmentation and solar elastosis suggest the role of chronic sun exposure in the pathogenesis of melasma. Presence of pendulous melanocytes is a characteristic feature of melasma. The presence of pendulous melanocytes may have prognostic implications in melasma.
Subject(s)
Epidermis/pathology , Facial Dermatoses/pathology , Melanosis/pathology , Adult , Atrophy/pathology , Biopsy , Cross-Sectional Studies , Facial Dermatoses/etiology , Female , Humans , Melanocytes/pathology , Melanosis/etiology , Middle Aged , Sunlight/adverse effects , Young AdultSubject(s)
Anus Diseases/etiology , Facial Dermatoses/etiology , Histiocytosis, Langerhans-Cell/diagnosis , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Anus Diseases/pathology , Facial Dermatoses/diagnosis , Facial Dermatoses/drug therapy , Hepatomegaly/diagnostic imaging , Hepatomegaly/etiology , Histiocytosis, Langerhans-Cell/complications , Histiocytosis, Langerhans-Cell/drug therapy , Humans , Lung Diseases/complications , Lung Diseases/diagnostic imaging , Male , RadiographySubject(s)
Facial Dermatoses/etiology , Gingival Diseases/etiology , Pemphigoid, Bullous/diagnosis , Adult , Cheek , Female , Humans , Nose , Pemphigoid, Bullous/complicationsSubject(s)
Facial Dermatoses/etiology , Mothers/psychology , Munchausen Syndrome by Proxy/complications , Munchausen Syndrome by Proxy/diagnosis , Adult , Blister/chemically induced , Child , Child, Preschool , Cicatrix, Hypertrophic/chemically induced , Facial Dermatoses/chemically induced , Female , Humans , Hydrochloric Acid/adverse effects , Hyperpigmentation/chemically induced , Male , Mother-Child Relations , Munchausen Syndrome by Proxy/psychologyABSTRACT
OBJECTIVES: To verify the frequency of oral and facial involvement in diagnosed leprosy patients. STUDY DESIGN: This study was performed on 100 leprosy patients (62 male, 38 female, mean ages 51.86±6.1). After explaining the study design, we studied descriptive information including: patient' s sex, age, job, place of birth, familial history of leprosy, types of disease (lepromatous, borderline and tuberculoid leprosy), ocular and oral lesions, facial involvement and neuropathy. The statistical signification was measured by chi-square test. RESULTS: A total of 46 (23 lepromatous, 15 borderline, and 8 tuberculoid leprosy) out of 100 patients with leprosy had oral lesions. Statistical analysis did not show any significant difference in frequency of oral lesions between different types of disease. Facial lesions were presented in 57 (39 lepromatous, 10 borderline, and 8 tuberculoid leprosy) patients. There was a statistical significant difference in frequency of facial manifestations between different types of leprosy. It has to be mentioned that, atrophy of nasal spine, facial nerve involvement, ocular lesions and facial deformity were seen in 15%, 17%, 22% and 44% of leprosy patients, respectively. CONCLUSION: Examination of leprosy patients should be extended to the oral mucosa because oral mucosa may be a secondary source of M.Leprae transmission and infection.
Subject(s)
Facial Dermatoses/etiology , Leprosy/complications , Mouth Diseases/etiology , Adult , Female , Humans , Male , Middle AgedSubject(s)
Dermatitis/diagnosis , Skin Care/methods , Dermatitis/etiology , Facial Dermatoses/diagnosis , Facial Dermatoses/etiology , Humans , Male , Middle Aged , Neglected Diseases/diagnosis , Neglected Diseases/etiology , Pain Measurement , Remission, Spontaneous , Risk Assessment , Severity of Illness Index , Skin Care/adverse effects , Trigeminal NeuralgiaABSTRACT
OBJECTIVE: The goal of this study was to evaluate the orofacial lesions in treated leprosy patients. PATIENTS AND METHODS: 160 treated patients at Maharogi Seva Samithi, Warora were examined clinically. RESULTS: Of 160 patients studied, 140 (87.5%) was of lepromatous types, 100 patients presented with depressed nasal bridge, 64 presented with hypopigmented macules on face. Intraoral examination revealed tongue abnormalities as a most common finding, with fissured tongue being the commonest feature. CONCLUSION: We conclude that though active lesions of leprosy are not present, manifestations such as fissured tongue may remain in treated leprosy patients.
Subject(s)
Facial Dermatoses/etiology , Facial Dermatoses/pathology , Leprosy/pathology , Mouth Diseases/pathology , Mouth Mucosa/pathology , Cross-Sectional Studies , Female , Humans , India , Leprostatic Agents/therapeutic use , Leprosy/complications , Leprosy/drug therapy , Male , Middle Aged , Mouth Diseases/etiologyABSTRACT
Cutaneous sporotrichosis, a subcutaneous mycotic infection is caused by the saprophytic, dimorphic fungus Sporothrix schenckii. It commonly presents as lymphocutaneous or fixed cutaneous lesions involving the upper extremities with facial lesions being seen more often in children. The lesions are polymorphic. The therapeutic response to saturated solution of potassium iodide is almost diagnostic. We describe a culture-proven case of cutaneous sporotrichosis of the face mimicking lupus vulgaris initially and basal cell carcinoma later, who did not tolerate potassium iodide and failed to respond to treatment with fluconazole. The patient had reactivation of infection following an infiltration of the scar with triamcinolone acetonide injection. Various other aspects of these unusual phenomena are also discussed.
Subject(s)
Anti-Inflammatory Agents/adverse effects , Facial Dermatoses/pathology , Facial Injuries/complications , Sporotrichosis/pathology , Triamcinolone/adverse effects , Adult , Anti-Inflammatory Agents/administration & dosage , Antifungal Agents/therapeutic use , Facial Dermatoses/drug therapy , Facial Dermatoses/etiology , Humans , Injections, Intralesional , Male , Sporotrichosis/drug therapy , Sporotrichosis/etiology , Triamcinolone/administration & dosageABSTRACT
AIM: The aim of the present study was to clinically evaluate the oral mucosa lesions of leprosy patients during and after multi-drug therapy. METHODS: Clinical examination, medical and dental history examination was performed in 100 leprosy patients. RESULTS: The results revealed that 71 patients, 50 men and 21 women, exibited oral lesions. The most frequent lesions were: fissured tongue (18 cases), inflammatory papillary hyperplasia (16 cases), chronic atrophic candidiasis (10 cases), fibroma (10 cases), erythematous candidiasis (eight cases), and traumatic ulceration (seven cases). CONCLUSION: We conclude that leprosy-related lesions are not present in patients undergoing treatment for leprosy, probably due to response to multidrug therapy.