ABSTRACT
BACKGROUND: Adnexal tumors of the skin are rare neoplasms that encompass a wide range of dermatologic entities. Here, we investigated the pattern of adnexal tumors of the skin in the All African Leprosy and Tuberculosis Rehabilitation and Training Center (ALERT) hospital retrospectively. METHODS: A hospital-based retrospective study was conducted at ALERT from histopathology records in the Armauer Hansen Research Institute (AHRI) pathology laboratory of patients diagnosed with any of the skin adnexal tumors during the time period January 2017 to December 2021. A structured data extraction sheet was used. Data entry was done using EpiData 4.6.0.6. Data were analyzed using SPSS version 25. RESULT: A total of 146 skin adnexal tumors were identified making the magnitude 2.8% of total biopsies. The 3rd decade of life was found to be the most common age group. Male-to-female ratio was 1 : 1.05. Majority of the tumors were benign (82.2%) and had sweat gland differentiation at 48.6%. Poroma (10.9%) was the most frequent tumor, whereas porocarcinoma (6.8%) made up the most frequent malignant tumor. The most common site was the head and neck region (48.6%). Only 21.2% of the tumors were correctly identified clinically. CONCLUSION: The magnitude of skin adnexal tumors is found to be slightly higher than other similar studies which could be because it was carried out in the largest dermatologic center in the country. The most common skin adnexal tumors identified, their localizations, and lines of differentiation are all in line with other studies. Histopathologic examination is mandatory for the accurate diagnosis of these tumors.
Subject(s)
Skin Neoplasms , Humans , Retrospective Studies , Female , Male , Adult , Ethiopia/epidemiology , Middle Aged , Young Adult , Adolescent , Skin Neoplasms/pathology , Skin Neoplasms/epidemiology , Skin Neoplasms/diagnosis , Child , Aged , Neoplasms, Adnexal and Skin Appendage/pathology , Neoplasms, Adnexal and Skin Appendage/epidemiology , Neoplasms, Adnexal and Skin Appendage/diagnosis , Child, Preschool , Biopsy , Aged, 80 and over , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/epidemiology , Head and Neck Neoplasms/diagnosis , Sweat Gland Neoplasms/pathology , Sweat Gland Neoplasms/epidemiology , Sweat Gland Neoplasms/diagnosisSubject(s)
Disseminated Intravascular Coagulation/pathology , Head and Neck Neoplasms/pathology , Hemangiosarcoma/pathology , Kasabach-Merritt Syndrome/pathology , Skin Neoplasms/pathology , Aged , Biopsy, Needle , Dexamethasone/administration & dosage , Disseminated Intravascular Coagulation/complications , Disseminated Intravascular Coagulation/diagnosis , Disseminated Intravascular Coagulation/therapy , Face , Follow-Up Studies , Head and Neck Neoplasms/complications , Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/therapy , Hemangiosarcoma/complications , Hemangiosarcoma/diagnosis , Hemangiosarcoma/therapy , Humans , Immunohistochemistry , Infusions, Intravenous , Kasabach-Merritt Syndrome/complications , Kasabach-Merritt Syndrome/diagnosis , Kasabach-Merritt Syndrome/therapy , Male , Platelet Transfusion/methods , Risk Assessment , Scalp , Skin Neoplasms/diagnosis , Treatment OutcomeSubject(s)
Head and Neck Neoplasms/pathology , Neoplasms, Adnexal and Skin Appendage/pathology , Nevus, Sebaceous of Jadassohn/pathology , Scalp/pathology , Adult , Head and Neck Neoplasms/complications , Head and Neck Neoplasms/metabolism , Humans , Male , Melanins/metabolism , Melanocytes/pathology , Neoplasms, Adnexal and Skin Appendage/complications , Neoplasms, Adnexal and Skin Appendage/metabolism , Nevus, Sebaceous of Jadassohn/complicationsABSTRACT
Epidermal nevus syndrome (ENS) is a rare disease, the pathogenesis of which is largely elusive. We, hereby, report an exclusive case of a 20-year-old man with verrucous ENS presented with dark colored papules and plaques along the Blaschko's lines present over the head and neck area along with fleshy growth in both eyes since birth. Limb length discrepancy and kyphoscoliosis were remarkable. Skin biopsy was compatible with verrucous epidermal nevus while the biopsy of the ocular lesion confirmed complex choristoma. MRI brain revealed calcification in the right temporal lobe. Bilateral arachnoid cyst in the middle cranial fossa, scleral osteoma in the posterior part of the right eyeball, and deformed calvarium were evident on CECT skull and orbit. The present illustration emphasizes the importance of a punctilious work up of the case.
Subject(s)
Abnormalities, Multiple/diagnosis , Choristoma/diagnosis , Head and Neck Neoplasms/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adipose Tissue , Adult , Arachnoid Cysts/diagnostic imaging , Bone Neoplasms/diagnostic imaging , Connective Tissue , Eye Diseases/diagnosis , Eye Neoplasms/diagnostic imaging , Humans , Kyphosis/diagnostic imaging , Lacrimal Apparatus , Male , Osteoma/diagnosis , Osteoma/diagnostic imaging , Radiography , Scoliosis/diagnostic imaging , Seizures/drug therapy , Skull/abnormalities , Syndrome , Young AdultABSTRACT
Follicular lymphoma is the most common type of primary cutaneous B-cell lymphomas with a predilection for the scalp, forehead, and trunk. Herein we report a case of primary cutaneous follicle center lymphoma on the scalp of 72-year-old female. The diagnosis was made histopathologically, confirming the presence of centrocytes and centroblasts. Complete resolution was achieved following administration of subcutaneous interferon α-2a at a dose of 4.5 × 106 IU three times weekly for 3 months.
Subject(s)
Head and Neck Neoplasms/drug therapy , Immunologic Factors/therapeutic use , Interferon-alpha/therapeutic use , Lymphoma, Follicular/drug therapy , Scalp , Skin Neoplasms/drug therapy , Aged , Female , Head and Neck Neoplasms/pathology , Humans , Interferon alpha-2 , Lymphoma, Follicular/pathology , Recombinant Proteins/therapeutic use , Scalp/pathology , Skin Neoplasms/pathologyABSTRACT
BACKGROUND: Leprosy is a chronic systemic infection caused by the bacillus Mycobacterium leprae. Cutaneous neoplasms have been observed in patients with leprosy. Also, albeit less commonly, M. leprae have been documented in the lesions of skin cancer. OBJECTIVE: To describe a 62-year-old man with chronic sun exposure and exposure to armadillos who subsequently developed lepromatous leprosy, to discuss the cutaneous malignancies that have occurred in patients with leprosy, and to review the literature concerning the concurrent presence of an infectious pathogen and a cutaneous neoplasm in the same lesion. METHODS: Our patient's basal cell carcinomas were excised, his abdominal plaques were biopsied, and his leprosy infection was treated with dapsone and rifampin. The types of cutaneous malignancies in leprosy patients and infectious pathogens concurrently found in lesions of skin tumors were summarized after evaluating previously published reports. RESULTS: Skin biopsies from our patient demonstrated M. leprae bacilli not only in his abdominal plaques, but also in all of his basal cell carcinoma lesions. Fungal, mycobacterial, and viral pathogens have concurrently been observed in skin lesions of basal cell carcinomas, Kaposi's sarcoma, melanoma, mycosis fungoides, and squamous cell carcinoma. CONCLUSION: Patients with leprosy can develop skin cancers and the histologic interpretation of those skin cancers can show evidence of leprosy. It is uncertain to what degree the decreased cell-mediated immunity in patients with lepromatous leprosy either enhances their susceptibility to and/or influences the course of their cutaneous neoplasms; also, in these patients, the coexistence of M. leprae organisms and cutaneous malignancy in the same lesion is likely to be secondary to the high bacillary load that is present.