1.
Indian J Dermatol Venereol Leprol
; 85(1): 56-59, 2019.
Article
in English
| MEDLINE
| ID: mdl-29536970
ABSTRACT
Advanced extramammary Paget's disease does not have a standardized treatment guideline as its incidence is low and has been rarely reported in literature. Here we describe a case of metastatic extramammary Paget's disease successfully treated with topical 5-fluorouracil (5-FU) and systemic pemetrexed. The therapy was safe without any appreciable adverse effects like diarrhea, rash, neutropenia or fatigue; maintaining remission for more than 6 months. Thus, we propose 5-FU and pemetrexed as the first-line therapy for advanced extramammary Paget's disease, especially for aged patients with unresectable skin lesions.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Fluorouracil/administration & dosage , Lymphatic Metastasis/diagnostic imaging , Paget Disease, Extramammary/diagnostic imaging , Paget Disease, Extramammary/drug therapy , Pemetrexed/administration & dosage , Administration, Topical , Aged , Antineoplastic Agents/administration & dosage , Humans , Male , Scrotum/drug effects , Scrotum/pathology , Treatment Outcome
2.
Indian J Dermatol Venereol Leprol
; 83(2): 276, 2017.
Article
in English
| MEDLINE
| ID: mdl-27549866